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341. Molecular Evidence of Sexual Transmission of Ebola Virus.
作者: Suzanne E Mate.;Jeffrey R Kugelman.;Tolbert G Nyenswah.;Jason T Ladner.;Michael R Wiley.;Thierry Cordier-Lassalle.;Athalia Christie.;Gary P Schroth.;Stephen M Gross.;Gloria J Davies-Wayne.;Shivam A Shinde.;Ratnesh Murugan.;Sonpon B Sieh.;Moses Badio.;Lawrence Fakoli.;Fahn Taweh.;Emmie de Wit.;Neeltje van Doremalen.;Vincent J Munster.;James Pettitt.;Karla Prieto.;Ben W Humrighouse.;Ute Ströher.;Joseph W DiClaro.;Lisa E Hensley.;Randal J Schoepp.;David Safronetz.;Joseph Fair.;Jens H Kuhn.;David J Blackley.;A Scott Laney.;Desmond E Williams.;Terrence Lo.;Alex Gasasira.;Stuart T Nichol.;Pierre Formenty.;Francis N Kateh.;Kevin M De Cock.;Fatorma Bolay.;Mariano Sanchez-Lockhart.;Gustavo Palacios.
来源: N Engl J Med. 2015年373卷25期2448-54页
A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. (Funded by the Defense Threat Reduction Agency and others.).
342. Docs and Nukes--Still a Live Issue.
Physicians have played a key role in warning governments and the public about the danger of nuclear war and the need to abolish nuclear weapons. That role is still needed: existing nuclear warheads pose an existential threat to humanity.
345. Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease.
作者: Stephen G Ellis.;Dean J Kereiakes.;D Christopher Metzger.;Ronald P Caputo.;David G Rizik.;Paul S Teirstein.;Marc R Litt.;Annapoorna Kini.;Ameer Kabour.;Steven O Marx.;Jeffrey J Popma.;Robert McGreevy.;Zhen Zhang.;Charles Simonton.;Gregg W Stone.; .
来源: N Engl J Med. 2015年373卷20期1905-15页
In patients with coronary artery disease who receive metallic drug-eluting coronary stents, adverse events such as late target-lesion failure may be related in part to the persistent presence of the metallic stent frame in the coronary-vessel wall. Bioresorbable vascular scaffolds have been developed to attempt to improve long-term outcomes.
347. A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds.
作者: .;Mohit Bhandari.;Kyle J Jeray.;Brad A Petrisor.;P J Devereaux.;Diane Heels-Ansdell.;Emil H Schemitsch.;Jeff Anglen.;Gregory J Della Rocca.;Clifford Jones.;Hans Kreder.;Susan Liew.;Paula McKay.;Steven Papp.;Parag Sancheti.;Sheila Sprague.;Trevor B Stone.;Xin Sun.;Stephanie L Tanner.;Paul Tornetta.;Ted Tufescu.;Stephen Walter.;Gordon H Guyatt.
来源: N Engl J Med. 2015年373卷27期2629-41页
The management of open fractures requires wound irrigation and débridement to remove contaminants, but the effectiveness of various pressures and solutions for irrigation remains controversial. We investigated the effects of castile soap versus normal saline irrigation delivered by means of high, low, or very low irrigation pressure.
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