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3553. Virological response after 6 week triple-drug regimens for hepatitis C: a proof-of-concept phase 2A cohort study.
作者: Anita Kohli.;Anuoluwapo Osinusi.;Zayani Sims.;Amy Nelson.;Eric G Meissner.;Lisa L Barrett.;Dimitra Bon.;Miriam M Marti.;Rachel Silk.;Colleen Kotb.;Chloe Gross.;Tim A Jolley.;Sreetha Sidharthan.;Tess Petersen.;Kerry Townsend.;D'Andrea Egerson.;Rama Kapoor.;Emily Spurlin.;Michael Sneller.;Michael Proschan.;Eva Herrmann.;Richard Kwan.;Gebeyehu Teferi.;Rohit Talwani.;Gabbie Diaz.;David E Kleiner.;Brad J Wood.;Jose Chavez.;Stephen Abbott.;William T Symonds.;G Mani Subramanian.;Phillip S Pang.;John McHutchison.;Michael A Polis.;Anthony S Fauci.;Henry Masur.;Shyam Kottilil.
来源: Lancet. 2015年385卷9973期1107-13页
Direct-acting antiviral drugs have a high cure rate and favourable tolerability for patients with hepatitis C virus (HCV). Shorter courses could improve affordability and adherence. Sofosbuvir and ledipasvir with ribavirin have high efficacy when taken for 8 weeks but not for 6 weeks. We assessed whether the addition of a third direct-acting antiviral drug to sofosbuvir and ledipasvir would allow a shorter treatment duration.
3557. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials.
作者: .;Jordan Fulcher.;Rachel O'Connell.;Merryn Voysey.;Jonathan Emberson.;Lisa Blackwell.;Borislava Mihaylova.;John Simes.;Rory Collins.;Adrienne Kirby.;Helen Colhoun.;Eugene Braunwald.;John La Rosa.;T R Pedersen.;Andrew Tonkin.;Barry Davis.;Peter Sleight.;Maria Grazia Franzosi.;Colin Baigent.;Anthony Keech.
来源: Lancet. 2015年385卷9976期1397-405页
Whether statin therapy is as effective in women as in men is debated, especially for primary prevention. We undertook a meta-analysis of statin trials in the Cholesterol Treatment Trialists' (CTT) Collaboration database to compare the effects of statin therapy between women and men.
3558. School-based suicide prevention programmes: the SEYLE cluster-randomised, controlled trial.
作者: Danuta Wasserman.;Christina W Hoven.;Camilla Wasserman.;Melanie Wall.;Ruth Eisenberg.;Gergö Hadlaczky.;Ian Kelleher.;Marco Sarchiapone.;Alan Apter.;Judit Balazs.;Julio Bobes.;Romuald Brunner.;Paul Corcoran.;Doina Cosman.;Francis Guillemin.;Christian Haring.;Miriam Iosue.;Michael Kaess.;Jean-Pierre Kahn.;Helen Keeley.;George J Musa.;Bogdan Nemes.;Vita Postuvan.;Pilar Saiz.;Stella Reiter-Theil.;Airi Varnik.;Peeter Varnik.;Vladimir Carli.
来源: Lancet. 2015年385卷9977期1536-44页
Suicidal behaviours in adolescents are a major public health problem and evidence-based prevention programmes are greatly needed. We aimed to investigate the efficacy of school-based preventive interventions of suicidal behaviours.
3559. Rubella.
作者: Nathaniel Lambert.;Peter Strebel.;Walter Orenstein.;Joseph Icenogle.;Gregory A Poland.
来源: Lancet. 2015年385卷9984期2297-307页
Rubella remains an important pathogen worldwide, with roughly 100,000 cases of congenital rubella syndrome estimated to occur every year. Rubella-containing vaccine is highly effective and safe and, as a result, endemic rubella transmission has been interrupted in the Americas since 2009. Incomplete rubella vaccination programmes result in continued disease transmission, as evidenced by recent large outbreaks in Japan and elsewhere. In this Seminar, we provide present results regarding rubella control, elimination, and eradication policies, and a brief review of new laboratory diagnostics. Additionally, we provide novel information about rubella-containing vaccine immunogenetics and review the emerging evidence of interindividual variability in humoral and cell-mediated innate and adaptive immune responses to rubella-containing vaccine and their association with haplotypes and single-nucleotide polymorphisms across the human genome.
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