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3523. Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial.
作者: Melvin D Lobo.;Paul A Sobotka.;Alice Stanton.;John R Cockcroft.;Neil Sulke.;Eamon Dolan.;Markus van der Giet.;Joachim Hoyer.;Stephen S Furniss.;John P Foran.;Adam Witkowski.;Andrzej Januszewicz.;Danny Schoors.;Konstantinos Tsioufis.;Benno J Rensing.;Benjamin Scott.;G André Ng.;Christian Ott.;Roland E Schmieder.; .
来源: Lancet. 2015年385卷9978期1634-41页
Hypertension contributes to cardiovascular morbidity and mortality. We assessed the safety and efficacy of a central iliac arteriovenous anastomosis to alter the mechanical arterial properties and reduce blood pressure in patients with uncontrolled hypertension.
3524. Acute pancreatitis.
Acute pancreatitis, an inflammatory disorder of the pancreas, is the leading cause of admission to hospital for gastrointestinal disorders in the USA and many other countries. Gallstones and alcohol misuse are long-established risk factors, but several new causes have emerged that, together with new aspects of pathophysiology, improve understanding of the disorder. As incidence (and admission rates) of acute pancreatitis increase, so does the demand for effective management. We review how to manage patients with acute pancreatitis, paying attention to diagnosis, differential diagnosis, complications, prognostic factors, treatment, and prevention of second attacks, and the possible transition from acute to chronic pancreatitis.
3527. The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial.
作者: Willeke F Westendorp.;Jan-Dirk Vermeij.;Elles Zock.;Imke J Hooijenga.;Nyika D Kruyt.;Hans J L W Bosboom.;Vincent I H Kwa.;Martijn Weisfelt.;Michel J M Remmers.;Robert ten Houten.;A H C M Tobien Schreuder.;Sarah E Vermeer.;Ewout J van Dijk.;Diederik W J Dippel.;Marcel G W Dijkgraaf.;Lodewijk Spanjaard.;Marinus Vermeulen.;Tom van der Poll.;Jan M Prins.;Frederique H Vermeij.;Yvo B W E M Roos.;Ruud P Kleyweg.;Henk Kerkhoff.;Matthijs C Brouwer.;Aeilko H Zwinderman.;Diederik van de Beek.;Paul J Nederkoorn.; .
来源: Lancet. 2015年385卷9977期1519-26页
In adults with acute stroke, infections occur commonly and are associated with an unfavourable functional outcome. In the Preventive Antibiotics in Stroke Study (PASS) we aimed to establish whether or not preventive antimicrobial therapy with a third-generation cephalosporin, ceftriaxone, improves functional outcome in patients with acute stroke.
3528. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.
作者: Claudine Angela Blum.;Nicole Nigro.;Matthias Briel.;Philipp Schuetz.;Elke Ullmer.;Isabelle Suter-Widmer.;Bettina Winzeler.;Roland Bingisser.;Hanno Elsaesser.;Daniel Drozdov.;Birsen Arici.;Sandrine Andrea Urwyler.;Julie Refardt.;Philip Tarr.;Sebastian Wirz.;Robert Thomann.;Christine Baumgartner.;Hervé Duplain.;Dieter Burki.;Werner Zimmerli.;Nicolas Rodondi.;Beat Mueller.;Mirjam Christ-Crain.
来源: Lancet. 2015年385卷9977期1511-8页
Clinical trials yielded conflicting data about the benefit of adding systemic corticosteroids for treatment of community-acquired pneumonia. We assessed whether short-term corticosteroid treatment reduces time to clinical stability in patients admitted to hospital for community-acquired pneumonia.
3532. Zotarolimus-eluting durable-polymer-coated stent versus a biolimus-eluting biodegradable-polymer-coated stent in unselected patients undergoing percutaneous coronary intervention (SORT OUT VI): a randomised non-inferiority trial.
作者: Bent Raungaard.;Lisette Okkels Jensen.;Hans-Henrik Tilsted.;Evald Høj Christiansen.;Michael Maeng.;Christian Juhl Terkelsen.;Lars Romer Krusell.;Anne Kaltoft.;Steen Dalby Kristensen.;Hans Erik Bøtker.;Leif Thuesen.;Jens Aarøe.;Svend Eggert Jensen.;Anton Boel Villadsen.;Per Thayssen.;Karsten Tange Veien.;Knud Nørregaard Hansen.;Anders Junker.;Morten Madsen.;Jan Ravkilde.;Jens Flensted Lassen.; .
来源: Lancet. 2015年385卷9977期1527-35页
New-generation drug-eluting coronary stents have reduced the risk of coronary events, especially in patients with complex disease or lesions. To what extent different stent platforms, polymers, and antiproliferative drugs affect outcomes, however, is unclear. We investigated the safety and efficacy of a third-generation stent by comparing a highly biocompatible durable-polymer-coated zotarolimus-eluting stent with a biodegradable-polymer-coated biolimus-eluting stent.
3536. Vitiligo.
作者: Khaled Ezzedine.;Viktoria Eleftheriadou.;Maxine Whitton.;Nanja van Geel.
来源: Lancet. 2015年386卷9988期74-84页
Vitiligo, an acquired pigmentary disorder of unknown origin, is the most frequent cause of depigmentation worldwide, with an estimated prevalence of 1%. The disorder can be psychologically devastating and stigmatising, especially in dark skinned individuals. Vitiligo is clinically characterised by the development of white macules due to the loss of functioning melanocytes in the skin or hair, or both. Two forms of the disease are well recognised: segmental and non-segmental vitiligo (the commonest form). To distinguish between these two forms is of prime importance because therapeutic options and prognosis are quite different. The importance of early treatment and understanding of the profound psychosocial effect of vitiligo will be emphasised throughout this Seminar.
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