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321. Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study.
作者: M Venerito.;C Helmke.;D Jechorek.;T Wex.;R Rosania.;K Antweiler.;J Weigt.;P Malfertheiner.
来源: BMC Gastroenterol. 2016年16卷1期85页
Leukotriene B4 (LTB4R and LTB4R2) and cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2) contribute to malignant cell transformation. We aimed to investigate the expression of LTB4R, LTB4R2, CYSLTR1 and CYSLTR2 in esophageal squamous cell carcinoma and adjacent non-transformed squamous epithelium of the esophagus, as well as in control biopsy samples from esophageal squamous epithelium of patients with functional dyspepsia.
322. The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review.
The human gut is the habitat for diverse and dynamic microbial ecosystem. The human microbiota plays a critical role in functions that sustain health and is a positive asset in host defenses. Establishment of the human intestinal microbiota during infancy may be influenced by multiple factors including delivery mode. Present review compiles existing evidences on the effect of delivery mode on the diversity and colonization pattern of infants gut microbiota.
323. Increased Activation of the TRESK K+ Mediates Vago-Vagal Reflex Malfunction in Diabetic Rats.
作者: Gintautas Grabauskas.;Xiaoyin Wu.;Il Song.;Shi-Yi Zhou.;Thomas Lanigan.;Chung Owyang.
来源: Gastroenterology. 2016年151卷5期910-922.e7页
Patients with diabetes have defects in the vagal afferent pathway that result in abnormal gastrointestinal function. We investigated whether selective increased activation of the 2-pore domain potassium channel TRESK (2-pore-domain weak inward-rectifying potassium channel-related spinal cord potassium channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in diabetic rats.
324. Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes.
作者: Yin Cao.;Reiko Nishihara.;Zhi Rong Qian.;Mingyang Song.;Kosuke Mima.;Kentaro Inamura.;Jonathan A Nowak.;David A Drew.;Paul Lochhead.;Katsuhiko Nosho.;Teppei Morikawa.;Xuehong Zhang.;Kana Wu.;Molin Wang.;Wendy S Garrett.;Edward L Giovannucci.;Charles S Fuchs.;Andrew T Chan.;Shuji Ogino.
来源: Gastroenterology. 2016年151卷5期879-892.e4页
Aspirin use reduces colorectal cancer risk. Aspirin, a nonsteroidal anti-inflammatory drug, inhibits prostaglandin-endoperoxide synthase 2 (PTGS2 or cyclooxygenase-2); PTGS2 promotes inflammation and suppresses T-cell-mediated adaptive immunity. We investigated whether the inverse association of aspirin use with colorectal carcinoma risk was stronger for tumors with lower degrees of lymphocytic infiltrates than for tumors with higher degrees of lymphocytic infiltrates.
325. Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats.
作者: Mingming Zhang.;Qian Zhou.;Robert G Dorfman.;Xiaoli Huang.;Tingting Fan.;Hao Zhang.;Jun Zhang.;Chenggong Yu.
来源: BMC Gastroenterol. 2016年16卷1期84页
Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities. Although the administration of butyrate improves homeostasis in patients and ameliorates IBD (Inflammatory Bowel Disease)-related lesions and symptoms, the anti-inflammatory mechanisms of butyrate still remain unclear. To explore the impact of butyrate on Treg (Regulatory T cell)/Th17 (T helper 17 cell) differentiation and colitis in rats.
326. Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects.
作者: Haruhisa Nakao.;Kenji Wakai.;Norimitsu Ishii.;Yuji Kobayashi.;Kiyoaki Ito.;Masashi Yoneda.;Mitsuru Mori.;Masanori Nojima.;Yasutoshi Kimura.;Takao Endo.;Masato Matsuyama.;Hiroshi Ishii.;Makoto Ueno.;Sawako Kuruma.;Naoto Egawa.;Keitaro Matsuo.;Satoyo Hosono.;Shinichi Ohkawa.;Kozue Nakamura.;Akiko Tamakoshi.;Mami Takahashi.;Kazuaki Shimada.;Takeshi Nishiyama.;Shogo Kikuchi.;Yingsong Lin.
来源: BMC Gastroenterol. 2016年16卷1期83页
Evidence supporting the associations between folate metabolizing gene polymorphisms and pancreatic cancer has been inconclusive. We examined their associations in a case-control study of Japanese subjects.
327. Clinical efficacy of adalimumab in Crohn's disease: a real practice observational study in Japan.
作者: Fuminao Takeshima.;Daisuke Yoshikawa.;Syuntaro Higashi.;Tomohito Morisaki.;Hidetoshi Oda.;Maho Ikeda.;Haruhisa Machida.;Kayoko Matsushima.;Hitomi Minami.;Yuko Akazawa.;Naoyuki Yamaguchi.;Ken Ohnita.;Hajime Isomoto.;Masato Ueno.;Kazuhiko Nakao.
来源: BMC Gastroenterol. 2016年16卷1期82页
There are few reports of the efficacy of adalimumab (ADA) for clinical remission and preventing postoperative recurrence in Crohn's disease (CD) in Asian real practice settings. We conducted a Japanese multicenter retrospective observational study.
328. Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis.
作者: Jia Yu.;Teng Zuo.;Wenhong Deng.;Qiao Shi.;Peng Ma.;Chen Chen.;Liang Zhao.;Kailiang Zhao.;Weixing Wang.
来源: BMC Gastroenterol. 2016年16卷1期81页
Poly(ADP-ribose) polymerase (PARP) participates in multi-organ failure in various inflammatory diseases including acute necrotizing pancreatitis (ANP). Since pancreatitis-associated adrenal insufficiency is partly caused by inflammatory damage to the adrenal cortex, we examined whether PARP antagonism could alleviate adrenal insufficiency in a rat model of ANP.
329. Pharmacological regimens for eradication of Helicobacter pylori: an overview of systematic reviews and network meta-analysis.
作者: Yiqiao Xin.;Jan Manson.;Lindsay Govan.;Robin Harbour.;Jenny Bennison.;Eleanor Watson.;Olivia Wu.
来源: BMC Gastroenterol. 2016年16卷1期80页
Approximately half of the world's population is infected with Helicobacter pylori (H.pylori), a bacterium shown to be linked with a series of gastrointestinal diseases. A growing number of systematic reviews (SRs) have been published comparing the effectiveness of different treatments for H.pylori infection but have not reached a consistent conclusion. The objective of this study is to provide an overview of SRs of pharmacological therapies for the eradication of H.pylori.
330. Comparison of sequential therapy and amoxicillin/tetracycline containing bismuth quadruple therapy for the first-line eradication of Helicobacter pylori: a prospective, multi-center, randomized clinical trial.
作者: Ju Yup Lee.;Nayoung Kim.;Kyung Sik Park.;Hyun Jin Kim.;Seon Mee Park.;Gwang Ho Baik.;Ki-Nam Shim.;Jung Hwan Oh.;Suck Chei Choi.;Sung Eun Kim.;Won Hee Kim.;Seon-Young Park.;Gwang Ha Kim.;Bong Eun Lee.;Yunju Jo.;Su Jin Hong.
来源: BMC Gastroenterol. 2016年16卷1期79页
The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resistance to tetracycline or to amoxicillin is relatively low. A 14-day modified bismuth quadruple protocol as first-line H. pylori treatment was compared with 10-day sequential therapy.
331. Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia.
The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms.
332. Peripheral blood toll-like receptor 4 correlates with rapid virological response to pegylated-interferon and ribavirin therapy in hepatitis C genotype 1 patients.
作者: Chuan-Mo Lee.;Tsung-Hui Hu.;Sheng-Nan Lu.;Jing-Houng Wang.;Chao-Hung Hung.;Chien-Hung Chen.;Yi-Hao Yen.
来源: BMC Gastroenterol. 2016年16卷1期73页
Toll-like receptors (TLRs) are effectors of the innate immune system that are able to recognize hepatitis C virus (HCV) and give rise to an immune response. Failure of interferon (IFN)-α-based treatment is related to host immunity. Therefore, we sought to study the clinical importance of TLRs in HCV genotype 1 patients who received pegylated IFN (PEG-IFN) plus ribavirin (RBV) therapy.
333. Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility.
Recent studies have implicated that members of the DICKKOPF (DKK) were causally involved in large number of human cancers. This study was designed to investigate the relationship between the genetic variations of DKK family genes and the risk of gastric cancer (GC).
334. Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation.
作者: Antti Kylökäs.;Katri Kaukinen.;Heini Huhtala.;Pekka Collin.;Markku Mäki.;Kalle Kurppa.
来源: BMC Gastroenterol. 2016年16卷1期76页
Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adult celiac disease patients.
335. Epilepsy as a risk factor for hepatic encephalopathy in patients with cirrhosis: a cohort study.
作者: Peter Jepsen.;Jakob Christensen.;Karin Weissenborn.;Hugh Watson.;Hendrik Vilstrup.
来源: BMC Gastroenterol. 2016年16卷1期77页
Epilepsy is associated with an increased mortality among cirrhosis patients, but the reasons are unknown. We aimed to determine whether epilepsy is a risk factor for developing hepatic encephalopathy (HE), which is a strong predictor of mortality.
336. Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer.
This study aimed to evaluate the clinical significance of cysteine-rich 61 (Cyr-61/CCN1) and cyclooxygenase-2 (COX-2), and further explored their combined prognostic significance in gastric cancer.
340. Trends in Liver Transplantation Multiple Listing Practices Associated With Disparities in Donor Availability: An Endless Pursuit to Implement the Final Rule.
作者: George Cholankeril.;Ryan B Perumpail.;Zeynep Tulu.;Channa R Jayasekera.;Stephen A Harrison.;Menghan Hu.;Carlos O Esquivel.;Aijaz Ahmed.
来源: Gastroenterology. 2016年151卷3期382-386.e2页 |