301. Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial.
作者: Marcus Mumme.;Andrea Barbero.;Sylvie Miot.;Anke Wixmerten.;Sandra Feliciano.;Francine Wolf.;Adelaide M Asnaghi.;Daniel Baumhoer.;Oliver Bieri.;Martin Kretzschmar.;Geert Pagenstert.;Martin Haug.;Dirk J Schaefer.;Ivan Martin.;Marcel Jakob.
来源: Lancet. 2016年388卷10055期1985-1994页
Articular cartilage injuries have poor repair capacity, leading to progressive joint damage, and cannot be restored predictably by either conventional treatments or advanced therapies based on implantation of articular chondrocytes. Compared with articular chondrocytes, chondrocytes derived from the nasal septum have superior and more reproducible capacity to generate hyaline-like cartilage tissues, with the plasticity to adapt to a joint environment. We aimed to assess whether engineered autologous nasal chondrocyte-based cartilage grafts allow safe and functional restoration of knee cartilage defects.
316. Improving outcomes of dialysis patients by population health management-the Global Chief Medical Officer Initiative.
作者: Bernard Canaud.;Jörgen Hegbrant.;Allen R Nissenson.;Claudia Barth.;Franklin Maddux.;Michael Etter.;Mahesh Krishnan.
来源: Lancet. 2016年388卷10055期1966-1967页 |