当前位置: 首页 >> 检索结果
281. Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.
作者: Wenjiang Yan.;Xiao Liu.;Hongxin Ma.;Hualin Zhang.;Xiaojia Song.;Lifen Gao.;Xiaohong Liang.;Chunhong Ma.
来源: Gut. 2015年64卷10期1593-604页
Tumour-associated macrophages (TAMs) and their alternative activation contribute greatly to the development of hepatocellular carcinoma (HCC). Tim-3 is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether Tim-3 is involved in the activation and the function of TAMs has not been reported.
282. A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.
作者: Bo Kong.;Weiwei Wu.;Tao Cheng.;Anna Melissa Schlitter.;Chengjia Qian.;Philipp Bruns.;Ziying Jian.;Carsten Jäger.;Ivonne Regel.;Susanne Raulefs.;Nora Behler.;Martin Irmler.;Johannes Beckers.;Helmut Friess.;Mert Erkan.;Jens T Siveke.;Andrea Tannapfel.;Stephan A Hahn.;Fabian J Theis.;Irene Esposito.;Jörg Kleeff.;Christoph W Michalski.
来源: Gut. 2016年65卷4期647-57页
Oncogenic Kras-activated robust Mek/Erk signals phosphorylate to the tuberous sclerosis complex (Tsc) and deactivates mammalian target of rapamycin (mTOR) suppression in pancreatic ductal adenocarcinoma (PDAC); however, Mek and mTOR inhibitors alone have demonstrated minimal clinical antitumor activity.
284. Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers.
作者: A Lavelle.;G Lennon.;O O'Sullivan.;N Docherty.;A Balfe.;A Maguire.;H E Mulcahy.;G Doherty.;D O'Donoghue.;J Hyland.;R P Ross.;J C Coffey.;K Sheahan.;P D Cotter.;F Shanahan.;D C Winter.;P R O'Connell.
来源: Gut. 2015年64卷10期1553-61页
The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection with deep sequencing of the gut microbiota to develop an integrated spatial assessment of the microbial community in controls and UC.
285. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.
作者: Gregory A Michelotti.;Anikia Tucker.;Marzena Swiderska-Syn.;Mariana Verdelho Machado.;Steve S Choi.;Leandi Kruger.;Erik Soderblom.;J Will Thompson.;Meredith Mayer-Salman.;Heather A Himburg.;Cynthia A Moylan.;Cynthia D Guy.;Katherine S Garman.;Richard T Premont.;John P Chute.;Anna Mae Diehl.
来源: Gut. 2016年65卷4期683-92页
The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. Perivascular cells in stem cell niches produce pleiotrophin (PTN) to inactivate the PTN receptor, protein tyrosine phosphatase receptor zeta-1 (PTPRZ1), thereby augmenting phosphoprotein-dependent signalling. We hypothesised that the DR is regulated by PTN/PTPRZ1 signalling.
287. Tenofovir monotherapy versus tenofovir and entecavir combination therapy in patients with entecavir-resistant chronic hepatitis B with multiple drug failure: results of a randomised trial.
作者: Young-Suk Lim.;Kwan Soo Byun.;Byung Chul Yoo.;So Young Kwon.;Yoon Jun Kim.;Jihyun An.;Han Chu Lee.;Yung Sang Lee.
来源: Gut. 2016年65卷5期852-60页
Little clinical data are available regarding the optimal treatment of patients who harbour entecavir (ETV)-resistant HBV.
288. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.
作者: Paola Martinelli.;Francesc Madriles.;Marta Cañamero.;Enrique Carrillo-de Santa Pau.;Natalia Del Pozo.;Carmen Guerra.;Francisco X Real.
来源: Gut. 2016年65卷3期476-86页
Gata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent acinar-ductal metaplasia, which is considered an initial step of mutant KRas-driven carcinogenesis. Therefore, the Gata6-null pancreas might represent a tumour-prone environment. We investigated whether Gata6 plays a role during pancreatic tumorigenesis.
289. Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
作者: Mingyang Song.;Reiko Nishihara.;Molin Wang.;Andrew T Chan.;Zhi Rong Qian.;Kentaro Inamura.;Xuehong Zhang.;Kimmie Ng.;Sun A Kim.;Kosuke Mima.;Yasutaka Sukawa.;Katsuhiko Nosho.;Charles S Fuchs.;Edward L Giovannucci.;Kana Wu.;Shuji Ogino.
来源: Gut. 2016年65卷2期296-304页
Evidence suggests protective effects of vitamin D and antitumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25-dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse association between vitamin D and colorectal cancer risk might be stronger for cancers with high-level immune response than those with low-level immune response.
290. Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.
作者: Antony Cougnoux.;Julien Delmas.;Lucie Gibold.;Tiphanie Faïs.;Chiara Romagnoli.;Frederic Robin.;Gabriel Cuevas-Ramos.;Eric Oswald.;Arlette Darfeuille-Michaud.;Fabio Prati.;Guillaume Dalmasso.;Richard Bonnet.
来源: Gut. 2016年65卷2期278-85页
Colorectal cancers (CRCs) are frequently colonised by colibactin toxin-producing Escherichia coli bacteria that induce DNA damage in host cells and exhibit protumoural activities. Our objective was to identify small molecules inhibiting the toxic effects induced by these colibactin-producing bacteria.
293. Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.
作者: Rong Fan.;Jian Sun.;Quan Yuan.;Qing Xie.;Xuefan Bai.;Qin Ning.;Jun Cheng.;Yanyan Yu.;Junqi Niu.;Guangfeng Shi.;Hao Wang.;Deming Tan.;Mobin Wan.;Shijun Chen.;Min Xu.;Xinyue Chen.;Hong Tang.;Jifang Sheng.;Fengmin Lu.;Jidong Jia.;Hui Zhuang.;Ningshao Xia.;Jinlin Hou.; .
来源: Gut. 2016年65卷2期313-20页
The investigation regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) during chronic hepatitis B (CHB) treatment is limited. The aim of this study was to determine the performance of anti-HBc as a predictor for hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with peginterferon (Peg-IFN) or nucleos(t)ide analogues (NUCs), respectively.
294. Adherence to surveillance guidelines after removal of colorectal adenomas: a large, community-based study.
作者: Else-Mariëtte B van Heijningen.;Iris Lansdorp-Vogelaar.;Ewout W Steyerberg.;S Lucas Goede.;Evelien Dekker.;Wilco Lesterhuis.;Frank ter Borg.;Juda Vecht.;Pieter Spoelstra.;Leopold Engels.;Clemens J M Bolwerk.;Robin Timmer.;Jan H Kleibeuker.;Jan J Koornstra.;Harry J de Koning.;Ernst J Kuipers.;Marjolein van Ballegooijen.
来源: Gut. 2015年64卷10期1584-92页
To determine adherence to recommended surveillance intervals in clinical practice.
295. Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of patients with resected pancreatic cancer.
作者: Saowanee Ngamruengphong.;Kristi M Swanson.;Nilay D Shah.;Michael B Wallace.
来源: Gut. 2015年64卷7期1105-10页
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) allows preoperative tissue confirmation of malignancy, but fear of tumour cell dissemination along the needle track has limited its use. We hypothesised that if tumour cell dissemination occurs with EUS-FNA, survival after complete resection would be impaired. We aimed to evaluate the association of preoperative EUS-FNA with long-term outcomes of patients with resected pancreatic cancer.
299. Geographical patterns of the standing and active human gut microbiome in health and IBD.
作者: Ateequr Rehman.;Philipp Rausch.;Jun Wang.;Jurgita Skieceviciene.;Gediminas Kiudelis.;Ketan Bhagalia.;Deepak Amarapurkar.;Limas Kupcinskas.;Stefan Schreiber.;Philip Rosenstiel.;John F Baines.;Stephan Ott.
来源: Gut. 2016年65卷2期238-48页
A global increase of IBD has been reported, especially in countries that previously had low incidence rates. Also, the knowledge of the human gut microbiome is steadily increasing, however, limited information regarding its variation on a global scale is available. In the light of the microbial involvement in IBDs, we aimed to (1) identify shared and distinct IBD-associated mucosal microbiota patterns from different geographical regions including Europe (Germany, Lithuania) and South Asia (India) and (2) determine whether profiling based on 16S rRNA transcripts provides additional resolution, both of which may hold important clinical relevance.
300. Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.
作者: Palak J Trivedi.;Willem J Lammers.;Henk R van Buuren.;Albert Parés.;Annarosa Floreani.;Harry L A Janssen.;Pietro Invernizzi.;Pier Maria Battezzati.;Cyriel Y Ponsioen.;Christophe Corpechot.;Raoul Poupon.;Marlyn J Mayo.;Andrew K Burroughs.;Frederik Nevens.;Andrew L Mason.;Kris V Kowdley.;Ana Lleo.;Llorenç Caballeria.;Keith D Lindor.;Bettina E Hansen.;Gideon M Hirschfield.; .
来源: Gut. 2016年65卷2期321-9页
Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC.
|