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283. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.
作者: Dalin Li.;Jean-Paul Achkar.;Talin Haritunians.;Jonathan P Jacobs.;Ken Y Hui.;Mauro D'Amato.;Stephan Brand.;Graham Radford-Smith.;Jonas Halfvarson.;Jan-Hendrik Niess.;Subra Kugathasan.;Carsten Büning.;L Philip Schumm.;Lambertus Klei.;Ashwin Ananthakrishnan.;Guy Aumais.;Leonard Baidoo.;Marla Dubinsky.;Claudio Fiocchi.;Jürgen Glas.;Raquel Milgrom.;Deborah D Proctor.;Miguel Regueiro.;Lisa A Simms.;Joanne M Stempak.;Stephan R Targan.;Leif Törkvist.;Yashoda Sharma.;Bernie Devlin.;James Borneman.;Hakon Hakonarson.;Ramnik J Xavier.;Mark Daly.;Steven R Brant.;John D Rioux.;Mark S Silverberg.;Judy H Cho.;Jonathan Braun.;Dermot P B McGovern.;Richard H Duerr.
来源: Gastroenterology. 2016年151卷4期724-32页
Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative colitis remain incompletely defined. Here, we aimed to identify novel associations between IBD and functional genetic variants using the Illumina ExomeChip (San Diego, CA).
284. Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck.
作者: Chikatoshi Katada.;Tetsuji Yokoyama.;Tomonori Yano.;Kazuhiro Kaneko.;Ichiro Oda.;Yuichi Shimizu.;Hisashi Doyama.;Tomoyuki Koike.;Kohei Takizawa.;Motohiro Hirao.;Hiroyuki Okada.;Takako Yoshii.;Kazuo Konishi.;Takenori Yamanouchi.;Takashi Tsuda.;Tai Omori.;Nozomu Kobayashi.;Tadakazu Shimoda.;Atsushi Ochiai.;Yusuke Amanuma.;Shinya Ohashi.;Tomonari Matsuda.;Hideki Ishikawa.;Akira Yokoyama.;Manabu Muto.
来源: Gastroenterology. 2016年151卷5期860-869.e7页
Some patients develop multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract, attributed to field cancerization; alcohol consumption has been associated with this process. We examined the association between multiple areas of dysplastic squamous epithelium with the development of SCC of the esophagus or head and neck cancer, as well as alcohol consumption and smoking.
285. Economic evaluation of pegylated interferon plus ribavirin for treatment of chronic hepatitis C in Thailand: genotype 1 and 6.
Pegylated interferon alpha 2a, alpha 2b and ribavirin have been included to the National List of Essential Medicines (NLEM) for treatment of only chronic hepatitis C genotypes 2 and 3 in Thailand. This reimbursement policy has not covered for other genotypes of hepatitis C virus infection (HCV) especially for genotypes 1 and 6 that account for 30-50 % of all HCV infection in Thailand. Therefore, this research determined whether pegylated interferon alpha 2a or alpha 2b plus ribavirin is more cost-effective than a palliative care for treatment of HCV genotype 1 and 6 in Thailand.
297. Elderly Onset Celiac Disease: A Narrative Review.
作者: Maria Cappello.;Gaetano C Morreale.;Anna Licata.
来源: Clin Med Insights Gastroenterol. 2016年9卷41-9页
Celiac sprue is a chronic disease, which usually occurs in children and young adults. However, it can develop in any age group, and the prevalence is increasing even in the elderly population. The atypical patterns of clinical presentation in this age group sometimes can cause a delay in diagnosis. Given the lower sensitivity and specificity of serological tests in the aged population, clinical suspect often arises in the presence of complications (autoimmune disorders, fractures, and finally, malignancy) and must be supported by endoscopic and imaging tools. In this review, we highlight the incidence and prevalence of celiac disease in the elderly, the patterns of clinical presentation, diagnosis, and the most frequent complications, with the aim of increasing awareness and reducing the diagnostic delay of celiac disease even in the elderly population.
298. Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Genotype 1 Hepatitis C Virus Infection in an Open-Label, Phase 2 Trial.
作者: Eric Lawitz.;Nancy Reau.;Federico Hinestrosa.;Mordechai Rabinovitz.;Eugene Schiff.;Aasim Sheikh.;Ziad Younes.;Robert Herring.;K Rajender Reddy.;Tram Tran.;Michael Bennett.;Ronald Nahass.;Jenny C Yang.;Sophia Lu.;Hadas Dvory-Sobol.;Luisa M Stamm.;Diana M Brainard.;John G McHutchison.;Brian Pearlman.;Mitchell Shiffman.;Trevor Hawkins.;Michael Curry.;Ira Jacobson.
来源: Gastroenterology. 2016年151卷5期893-901.e1页
The best regimen to re-treat patients who do not respond to direct-acting antivirals (DAAs) and the feasibility of further shortening regimens is unclear. We assessed the efficacy and safety of the combination of the nucleotide polymerase inhibitor sofosbuvir, the NS5A inhibitor velpatasvir, and the NS3/4A protease inhibitor GS-9857 in patients with hepatitis C virus genotype 1 infection.
299. Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial.
作者: Edward J Gane.;Kris V Kowdley.;David Pound.;Catherine A M Stedman.;Mitchell Davis.;Kyle Etzkorn.;Stuart C Gordon.;David Bernstein.;Gregory Everson.;Maribel Rodriguez-Torres.;Naoky Tsai.;Omer Khalid.;Jenny C Yang.;Sophia Lu.;Hadas Dvory-Sobol.;Luisa M Stamm.;Diana M Brainard.;John G McHutchison.;Myron Tong.;Raymond T Chung.;Kimberly Beavers.;John E Poulos.;Paul Y Kwo.;Mindie H Nguyen.
来源: Gastroenterology. 2016年151卷5期902-909页
Studies are needed to determine the optimal regimen for patients with chronic hepatitis C virus (HCV) genotype 2, 3, 4, or 6 infections whose prior course of antiviral therapy has failed, and the feasibility of shortening treatment duration. We performed a phase 2 study to determine the efficacy and safety of the combination of the nucleotide polymerase inhibitor sofosbuvir, the NS5A inhibitor velpatasvir, and the NS3/4A protease inhibitor GS-9857 in these patients.
300. Colonic polyp histopathology and location in a community-based sample of older adults.
作者: Heather S Laird-Fick.;Gurveen Chahal.;Ade Olomu.;Joseph Gardiner.;James Richard.;Nikolay Dimitrov.
来源: BMC Gastroenterol. 2016年16卷1期90页
Colorectal cancer and its precursors are highly prevalent in developed countries. Estimates in the available literature for prevalence of right-sided-only lesions vary between 20.5 and 48.1 %, with association with female gender and advancing age. Since the original polyp studies, premalignant potential of sessile serrated adenomas has been described and screening utilization of colonoscopy in men, women, and older adults has increased. This study describes the histopathology and distribution of colorectal polyps by age and gender in the post-screening era.
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