2834. New guidelines for prevention and management of implantable cardiac electronic device-related infection.
作者: Jonathan A T Sandoe.;Gavin Barlow.;John B Chambers.;Michael Gammage.;Achyut Guleri.;Philip Howard.;Ewan Olson.;John D Perry.;Bernard D Prendergast.;Michael J Spry.;Richard P Steeds.;Muzahir H Tayebjee.;Richard Watkin.
来源: Lancet. 2015年385卷9984期2225-6页 2838. Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial.
作者: Stephan Glund.;Joachim Stangier.;Michael Schmohl.;Dietmar Gansser.;Stephen Norris.;Joanne van Ryn.;Benjamin Lang.;Steven Ramael.;Viktoria Moschetti.;Fredrik Gruenenfelder.;Paul Reilly.;Jörg Kreuzer.
来源: Lancet. 2015年386卷9994期680-90页
Idarucizumab is a monoclonal antibody fragment that binds dabigatran with high affinity in a 1:1 molar ratio. We investigated the safety, tolerability, and efficacy of increasing doses of idarucizumab for the reversal of anticoagulant effects of dabigatran in a two-part phase 1 study (rising-dose assessment and dose-finding, proof-of-concept investigation). Here we present the results of the proof-of-concept part of the study.
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