264. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 34-2015. A 36-Year-Old Woman with a Lung Mass, Pleural Effusion, and Hip Pain.
作者: Arezou Khosroshahi.;Subba R Digumarthy.;Fiona K Gibbons.;Vikram Deshpande.
来源: N Engl J Med. 2015年373卷18期1762-72页 268. Excess Mortality among Persons with Type 2 Diabetes.
作者: Mauro Tancredi.;Annika Rosengren.;Ann-Marie Svensson.;Mikhail Kosiborod.;Aldina Pivodic.;Soffia Gudbjörnsdottir.;Hans Wedel.;Mark Clements.;Sofia Dahlqvist.;Marcus Lind.
来源: N Engl J Med. 2015年373卷18期1720-32页
The excess risks of death from any cause and death from cardiovascular causes among persons with type 2 diabetes and various levels of glycemic control and renal complications are unknown. In this registry-based study, we assessed these risks according to glycemic control and renal complications among persons with type 2 diabetes.
269. DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
作者: Joaquin Mateo.;Suzanne Carreira.;Shahneen Sandhu.;Susana Miranda.;Helen Mossop.;Raquel Perez-Lopez.;Daniel Nava Rodrigues.;Dan Robinson.;Aurelius Omlin.;Nina Tunariu.;Gunther Boysen.;Nuria Porta.;Penny Flohr.;Alexa Gillman.;Ines Figueiredo.;Claire Paulding.;George Seed.;Suneil Jain.;Christy Ralph.;Andrew Protheroe.;Syed Hussain.;Robert Jones.;Tony Elliott.;Ursula McGovern.;Diletta Bianchini.;Jane Goodall.;Zafeiris Zafeiriou.;Chris T Williamson.;Roberta Ferraldeschi.;Ruth Riisnaes.;Bernardette Ebbs.;Gemma Fowler.;Desamparados Roda.;Wei Yuan.;Yi-Mi Wu.;Xuhong Cao.;Rachel Brough.;Helen Pemberton.;Roger A'Hern.;Amanda Swain.;Lakshmi P Kunju.;Rosalind Eeles.;Gerhardt Attard.;Christopher J Lord.;Alan Ashworth.;Mark A Rubin.;Karen E Knudsen.;Felix Y Feng.;Arul M Chinnaiyan.;Emma Hall.;Johann S de Bono.
来源: N Engl J Med. 2015年373卷18期1697-708页
Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.
|