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2621. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.
作者: Sotirios Tsimikas.;Nicholas J Viney.;Steven G Hughes.;Walter Singleton.;Mark J Graham.;Brenda F Baker.;Jennifer L Burkey.;Qingqing Yang.;Santica M Marcovina.;Richard S Geary.;Rosanne M Crooke.;Joseph L Witztum.
来源: Lancet. 2015年386卷10002期1472-83页
Lipoprotein(a) (Lp[a]) is a risk factor for cardiovascular disease and calcific aortic valve stenosis. No effective therapies to lower plasma Lp(a) concentrations exist. We have assessed the safety, pharmacokinetics, and pharmacodynamics of ISIS-APO(a)Rx, a second-generation antisense drug designed to reduce the synthesis of apolipoprotein(a) (apo[a]) in the liver.
2622. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial.
作者: Sandra Vennix.;Gijsbert D Musters.;Irene M Mulder.;Hilko A Swank.;Esther C Consten.;Eric H Belgers.;Anna A van Geloven.;Michael F Gerhards.;Marc J Govaert.;Wilhelmina M van Grevenstein.;Anton G Hoofwijk.;Philip M Kruyt.;Simon W Nienhuijs.;Marja A Boermeester.;Jefrey Vermeulen.;Susan van Dieren.;Johan F Lange.;Willem A Bemelman.; .
来源: Lancet. 2015年386卷10000期1269-1277页
Case series suggest that laparoscopic peritoneal lavage might be a promising alternative to sigmoidectomy in patients with perforated diverticulitis. We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in patients with purulent perforated diverticulitis, with respect to overall long-term morbidity and mortality.
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