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242. Immunochemical faecal occult blood testing to screen for colorectal cancer: can the screening interval be extended?
作者: Ulrike Haug.;Esmée J Grobbee.;Iris Lansdorp-Vogelaar.;Manon C W Spaander.;Ernst J Kuipers.
来源: Gut. 2017年66卷7期1262-1267页
Colorectal cancer (CRC) screening programmes based on faecal immunochemical testing for haemoglobin (FIT) typically use a screening interval of 2 years. We aimed to estimate how alternative FIT strategies that use a lower than usual positivity threshold followed by a longer screening interval compare with conventional strategies.
243. Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease.
作者: Timothy Hardy.;Mujdat Zeybel.;Christopher P Day.;Christian Dipper.;Steven Masson.;Stuart McPherson.;Elsbeth Henderson.;Dina Tiniakos.;Steve White.;Jeremy French.;Derek A Mann.;Quentin M Anstee.;Jelena Mann.
来源: Gut. 2017年66卷7期1321-1328页
Liver biopsy is currently the most reliable way of evaluating liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Its inherent risks limit its widespread use. Differential liver DNA methylation of peroxisome proliferator-activated receptor gamma (PPARγ) gene promoter has recently been shown to stratify patients in terms of fibrosis severity but requires access to liver tissue. The aim of this study was to assess whether DNA methylation of circulating DNA could be detected in human plasma and potentially used to stratify liver fibrosis severity in patients with NAFLD.
245. Tumour-associated and non-tumour-associated microbiota in colorectal cancer.
作者: Burkhardt Flemer.;Denise B Lynch.;Jillian M R Brown.;Ian B Jeffery.;Feargal J Ryan.;Marcus J Claesson.;Micheal O'Riordain.;Fergus Shanahan.;Paul W O'Toole.
来源: Gut. 2017年66卷4期633-643页
A signature that unifies the colorectal cancer (CRC) microbiota across multiple studies has not been identified. In addition to methodological variance, heterogeneity may be caused by both microbial and host response differences, which was addressed in this study.
246. Propranolol improves endothelial dysfunction in advanced cirrhosis: the 'endothelial exhaustion' hypothesis.
作者: Anderson Brito-Azevedo.;Renata de Mello Perez.;Henrique Sérgio Moraes Coelho.;Eduardo de Souza Martins Fernandes.;Raquel Carvalho Castiglione.;Cristiane Alves Villela-Nogueira.;Eliete Bouskela.
来源: Gut. 2016年65卷8期1391-2页 248. Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension.
作者: Ester Garcia-Pras.;Javier Gallego.;Laura Coch.;Marc Mejias.;Gonzalo Fernandez-Miranda.;Ricardo Pardal.;Jaime Bosch.;Raul Mendez.;Mercedes Fernandez.
来源: Gut. 2017年66卷7期1306-1320页
Pathological neovascularisation is intimately involved in portal hypertension (PH). Here, we determined the contribution of vascular stem/progenitor cells (VSPCs) to neovessel growth in PH and whether the RNA-binding protein cytoplasmic polyadenylation element binding protein-4 (CPEB4) was behind the mechanism controlling VSPC function.
249. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial.
作者: Keith McIntosh.;David E Reed.;Theresa Schneider.;Frances Dang.;Ammar H Keshteli.;Giada De Palma.;Karen Madsen.;Premysl Bercik.;Stephen Vanner.
来源: Gut. 2017年66卷7期1241-1251页
To gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms, the metabolome and the microbiome of patients with IBS.
250. The learning curve to achieve satisfactory completion rates in upper GI endoscopy: an analysis of a national training database.
作者: S T Ward.;A Hancox.;M A Mohammed.;T Ismail.;E A Griffiths.;R Valori.;P Dunckley.
来源: Gut. 2017年66卷6期1022-1033页
The aim of this study was to determine the number of OGDs (oesophago-gastro-duodenoscopies) trainees need to perform to acquire competency in terms of successful unassisted completion to the second part of the duodenum 95% of the time.
251. Pathogenicity of IgG in patients with IgG4-related disease.
作者: Masahiro Shiokawa.;Yuzo Kodama.;Katsutoshi Kuriyama.;Kenichi Yoshimura.;Teruko Tomono.;Toshihiro Morita.;Nobuyuki Kakiuchi.;Tomoaki Matsumori.;Atsushi Mima.;Yoshihiro Nishikawa.;Tatsuki Ueda.;Motoyuki Tsuda.;Yuki Yamauchi.;Ryuki Minami.;Yojiro Sakuma.;Yuji Ota.;Takahisa Maruno.;Akira Kurita.;Yugo Sawai.;Yoshihisa Tsuji.;Norimitsu Uza.;Kazuyoshi Matsumura.;Tomohiro Watanabe.;Kenji Notohara.;Tatsuaki Tsuruyama.;Hiroshi Seno.;Tsutomu Chiba.
来源: Gut. 2016年65卷8期1322-32页
IgG4-related disease (IgG4-RD) is a systemic disease characterised by elevated serum IgG4 and IgG4-positive lymphoplasmacytic infiltration in the affected tissues. The pathogenic role of IgGs, including IgG4, in patients with IgG4-RD, however, is unknown.
253. Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
作者: Tobias Schwerd.;Sumeet Pandey.;Huei-Ting Yang.;Katrin Bagola.;Elisabeth Jameson.;Jonathan Jung.;Robin H Lachmann.;Neil Shah.;Smita Y Patel.;Claire Booth.;Heiko Runz.;Gesche Düker.;Ruth Bettels.;Marianne Rohrbach.;Subra Kugathasan.;Helen Chapel.;Satish Keshav.;Abdul Elkadri.;Nick Platt.;Alexio M Muise.;Sibylle Koletzko.;Ramnik J Xavier.;Thorsten Marquardt.;Fiona Powrie.;James E Wraith.;Mads Gyrd-Hansen.;Frances M Platt.;Holm H Uhlig.
来源: Gut. 2017年66卷6期1060-1073页
Patients with Niemann-Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with IBD, but neither the significance nor the functional mechanism of this association is clear. We studied bacterial handling and antibacterial autophagy in patients with NPC1.
255. The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway.
作者: Jianxiang Chen.;Muthukumar Rajasekaran.;Hongping Xia.;Xiaoqian Zhang.;Shik Nie Kong.;Karthik Sekar.;Veerabrahma Pratap Seshachalam.;Amudha Deivasigamani.;Brian Kim Poh Goh.;London Lucien Ooi.;Wanjin Hong.;Kam M Hui.
来源: Gut. 2016年65卷9期1522-34页
Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Alterations in microtubule-associated proteins (MAPs) have been observed in HCC. However, the mechanisms underlying these alterations remain poorly understood. Our aim was to study the roles of the MAP protein regulator of cytokinesis 1 (PRC1) in hepatocarcinogenesis and early HCC recurrence.
256. Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study.
作者: Kazunari Murakami.;Yuuichi Sakurai.;Madoka Shiino.;Nobuo Funao.;Akira Nishimura.;Masahiro Asaka.
来源: Gut. 2016年65卷9期1439-46页
The objective of this study was to assess the efficacy, safety and tolerability of vonoprazan, a novel potassium-competitive acid blocker, as a component of Helicobacter pylori eradication therapy.
257. Red signs and not severity of cirrhosis should determine non-selective β-blocker treatment in Child-Pugh C cirrhosis with small varices: increased risk of hepatorenal syndrome and death beyond 6 months of propranolol use.
作者: Georgios N Kalambokis.;Gerasimos Baltayiannis.;Leonidas Christou.;Dimitrios Christodoulou.
来源: Gut. 2016年65卷7期1228-30页 259. Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis.
作者: Gail B Gifford.;Elise S Demitrack.;Theresa M Keeley.;Andrew Tam.;Nilsa La Cunza.;Priya H Dedhia.;Jason R Spence.;Diane M Simeone.;Ichiko Saotome.;Angeliki Louvi.;Christian W Siebel.;Linda C Samuelson.
来源: Gut. 2017年66卷6期1001-1011页
We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue.
260. Chronicles of a cancer foretold: 35 years of gastric cancer risk assessment.
作者: Massimo Rugge.;Robert M Genta.;David Y Graham.;Francesco Di Mario.;Luiz Gonzaga Vaz Coelho.;Nayoung Kim.;Peter Malfertheiner.;Kentaro Sugano.;Vladislav Tsukanov.;Pelayo Correa.
来源: Gut. 2016年65卷5期721-5页 |