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222. Sequential shear-wave elastography of liver and spleen rules out clinically significant portal hypertension in compensated advanced chronic liver disease.
作者: Christian Jansen.;Christopher Bogs.;Aleksander Krag.;Sven Francque.;Jonel Trebicka.
来源: Gut. 2017年66卷3期558-559页 223. Narrow band imaging optical diagnosis of small colorectal polyps in routine clinical practice: the Detect Inspect Characterise Resect and Discard 2 (DISCARD 2) study.
作者: Colin J Rees.;Praveen T Rajasekhar.;Ana Wilson.;Helen Close.;Matthew D Rutter.;Brian P Saunders.;James E East.;Rebecca Maier.;Morgan Moorghen.;Usman Muhammad.;Helen Hancock.;Anthoor Jayaprakash.;Chris MacDonald.;Arvind Ramadas.;Anjan Dhar.;James M Mason.
来源: Gut. 2017年66卷5期887-895页
Accurate optical characterisation and removal of small adenomas (<10 mm) at colonoscopy would allow hyperplastic polyps to be left in situ and surveillance intervals to be determined without the need for histopathology. Although accurate in specialist practice the performance of narrow band imaging (NBI), colonoscopy in routine clinical practice is poorly understood.
225. The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS.
作者: J Tack.;K Schumacher.;G Tonini.;S Scartoni.;A Capriati.;C A Maggi.; .
来源: Gut. 2017年66卷8期1403-1413页
Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea (IBS-D). Our aim was to study the efficacy and safety of ibodutant, a selective neurokinin-2 (NK2) receptor antagonist, in patients with IBS-D.
226. Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.
作者: Yohei Masugi.;Reiko Nishihara.;Juhong Yang.;Kosuke Mima.;Annacarolina da Silva.;Yan Shi.;Kentaro Inamura.;Yin Cao.;Mingyang Song.;Jonathan A Nowak.;Xiaoyun Liao.;Katsuhiko Nosho.;Andrew T Chan.;Marios Giannakis.;Adam J Bass.;F Stephen Hodi.;Gordon J Freeman.;Scott Rodig.;Charles S Fuchs.;Zhi Rong Qian.;Shuji Ogino.
来源: Gut. 2017年66卷8期1463-1473页
Evidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune checkpoint ligand repress antitumour immunity through its interaction with the PDCD1 (programmed cell death 1, PD-1) receptor of T lymphocytes in various tumours. We hypothesised that tumour CD274 expression levels might be inversely associated with T-cell densities in colorectal carcinoma tissue.
227. Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.
作者: Thibaut Duparc.;Hubert Plovier.;Vannina G Marrachelli.;Matthias Van Hul.;Ahmed Essaghir.;Marcus Ståhlman.;Sébastien Matamoros.;Lucie Geurts.;Mercedes M Pardo-Tendero.;Céline Druart.;Nathalie M Delzenne.;Jean-Baptiste Demoulin.;Schalk W van der Merwe.;Jos van Pelt.;Fredrik Bäckhed.;Daniel Monleon.;Amandine Everard.;Patrice D Cani.
来源: Gut. 2017年66卷4期620-632页
To examine the role of hepatocyte myeloid differentiation primary-response gene 88 (MyD88) on glucose and lipid metabolism.
228. Opposite roles of cannabinoid receptors 1 and 2 in hepatocarcinogenesis.
作者: Ki-Tae Suk.;Ingmar Mederacke.;Geum-Youn Gwak.;Sung Won Cho.;Adebowale Adeyemi.;Richard Friedman.;Robert F Schwabe.
来源: Gut. 2016年65卷10期1721-32页
The endocannabinoid system (ECS) exerts key roles in the development of liver fibrosis and fatty liver, two diseases that promote the development of hepatocellular carcinoma (HCC). Although cannabinoids exert potent antitumour effects in vitro, the contribution of the ECS to carcinogenesis in vivo remains elusive.
229. Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection.
作者: Janett Fischer.;Alexander N R Weber.;Stephan Böhm.;Sabine Dickhöfer.;Souhayla El Maadidi.;Danilo Deichsel.;Viola Knop.;Hartwig Klinker.;Bernd Möller.;Jens Rasenack.;Lisa Wang.;Manu Sharma.;Holger Hinrichsen.;Ulrich Spengler.;Peter Buggisch.;Christoph Sarrazin.;Michael Pawlita.;Tim Waterboer.;Manfred Wiese.;Elsbeth Probst-Müller.;Raffaele Malinverni.;Pierre-Yves Bochud.;Clair Gardiner.;Cliona O'Farrelly.;Thomas Berg.
来源: Gut. 2017年66卷10期1829-1837页
As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 were investigated for their effect on disease progression.
233. Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer.
作者: Gemma Ferrer-Mayorga.;Gonzalo Gómez-López.;Antonio Barbáchano.;Asunción Fernández-Barral.;Cristina Peña.;David G Pisano.;Ramón Cantero.;Federico Rojo.;Alberto Muñoz.;María Jesús Larriba.
来源: Gut. 2017年66卷8期1449-1462页
Colorectal cancer (CRC) is a major health concern. Vitamin D deficiency is associated with high CRC incidence and mortality, suggesting a protective effect of vitamin D against this disease. Given the strong influence of tumour stroma on cancer progression, we investigated the potential effects of the active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on CRC stroma.
234. The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.
作者: Mi Young Lim.;Hyun Ju You.;Hyo Shin Yoon.;Bomi Kwon.;Jae Yoon Lee.;Sunghee Lee.;Yun-Mi Song.;Kayoung Lee.;Joohon Sung.;GwangPyo Ko.
来源: Gut. 2017年66卷6期1031-1038页
Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remains limited. Here, we investigated the links among host genetic factors, gut microbiota and MetS in humans.
238. Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer.
作者: Heidi Griesmann.;Christof Drexel.;Nada Milosevic.;Bence Sipos.;Jonas Rosendahl.;Thomas M Gress.;Patrick Michl.
来源: Gut. 2017年66卷7期1278-1285页
Tumour-associated macrophages play an important role in mediating tumour progression. In pancreatic cancer, infiltrating macrophages are known to mediate tumour progression and have been identified in invasive tumours and in early preinvasive pancreatic intraepithelial precursor lesions. We aimed to study the impact of pharmacological macrophage depletion by liposomal clodronate in a genetic mouse model of pancreatic cancer.
240. Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver.
作者: Ibrahim M Sayed.;Lieven Verhoye.;Laurence Cocquerel.;Florence Abravanel.;Lander Foquet.;Claire Montpellier.;Yannick Debing.;Ali Farhoudi.;Czeslaw Wychowski.;Jean Dubuisson.;Geert Leroux-Roels.;Johan Neyts.;Jacques Izopet.;Thomas Michiels.;Philip Meuleman.
来源: Gut. 2017年66卷5期920-929页
The hepatitis E virus (HEV) is responsible for approximately 20 million infections per year worldwide. Although most infected people can spontaneously clear an HEV infection, immune-compromised individuals may evolve towards chronicity. Chronic HEV infection can be cured using ribavirin, but viral isolates with low ribavirin sensitivity have recently been identified. Although some HEV isolates can be cultured in vitro, in vivo studies are essentially limited to primates and pigs. Since the use of these animals is hampered by financial, practical and/or ethical concerns, we evaluated if human liver chimeric mice could serve as an alternative.
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