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201. Transient and 2-Dimensional Shear-Wave Elastography Provide Comparable Assessment of Alcoholic Liver Fibrosis and Cirrhosis.
作者: Maja Thiele.;Sönke Detlefsen.;Linda Sevelsted Møller.;Bjørn Stæhr Madsen.;Janne Fuglsang Hansen.;Annette Dam Fialla.;Jonel Trebicka.;Aleksander Krag.
来源: Gastroenterology. 2016年150卷1期123-33页
Alcohol abuse causes half of all deaths from cirrhosis in the West, but few tools are available for noninvasive diagnosis of alcoholic liver disease. We evaluated 2 elastography techniques for diagnosis of alcoholic fibrosis and cirrhosis; liver biopsy with Ishak score and collagen-proportionate area were used as reference.
202. Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.
作者: Camille Pochard.;Sabrina Coquenlorge.;Julie Jaulin.;Nicolas Cenac.;Nathalie Vergnolle.;Guillaume Meurette.;Marie Freyssinet.;Michel Neunlist.;Malvyne Rolli-Derkinderen.
来源: Gastroenterology. 2016年150卷1期168-80页
Enteric glial cells (EGCs) produce soluble mediators that regulate homeostasis and permeability of the intestinal epithelial barrier (IEB). We investigated the profile of polyunsaturated fatty acid (PUFA) metabolites produced by EGCs from rats and from patients with Crohn's disease (CD), compared with controls, along with the ability of one of these metabolites, 15-hydroxyeicosatetraenoic acid (15-HETE), to regulate the permeability of the IEB.
217. Qualitative analysis of patient-centered decision attributes associated with initiating hepatitis C treatment.
作者: Jessica L Zuchowski.;Alison B Hamilton.;Jeffrey M Pyne.;Jack A Clark.;Aanand D Naik.;Donna L Smith.;Fasiha Kanwal.
来源: BMC Gastroenterol. 2015年15卷124页
In this era of a constantly changing landscape of antiviral treatment options for chronic viral hepatitis C (CHC), shared clinical decision-making addresses the need to engage patients in complex treatment decisions. However, little is known about the decision attributes that CHC patients consider when making treatment decisions. We identify key patient-centered decision attributes, and explore relationships among these attributes, to help inform the development of a future CHC shared decision-making aid.
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