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202. Trial of Continuous or Interrupted Chest Compressions during CPR.
作者: Graham Nichol.;Brian Leroux.;Henry Wang.;Clifton W Callaway.;George Sopko.;Myron Weisfeldt.;Ian Stiell.;Laurie J Morrison.;Tom P Aufderheide.;Sheldon Cheskes.;Jim Christenson.;Peter Kudenchuk.;Christian Vaillancourt.;Thomas D Rea.;Ahamed H Idris.;Riccardo Colella.;Marshal Isaacs.;Ron Straight.;Shannon Stephens.;Joe Richardson.;Joe Condle.;Robert H Schmicker.;Debra Egan.;Susanne May.;Joseph P Ornato.; .
来源: N Engl J Med. 2015年373卷23期2203-14页
During cardiopulmonary resuscitation (CPR) in patients with out-of-hospital cardiac arrest, the interruption of manual chest compressions for rescue breathing reduces blood flow and possibly survival. We assessed whether outcomes after continuous compressions with positive-pressure ventilation differed from those after compressions that were interrupted for ventilations at a ratio of 30 compressions to two ventilations.
203. Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation.
作者: Daniel Goldstein.;Alan J Moskowitz.;Annetine C Gelijns.;Gorav Ailawadi.;Michael K Parides.;Louis P Perrault.;Judy W Hung.;Pierre Voisine.;Francois Dagenais.;A Marc Gillinov.;Vinod Thourani.;Michael Argenziano.;James S Gammie.;Michael Mack.;Philippe Demers.;Pavan Atluri.;Eric A Rose.;Karen O'Sullivan.;Deborah L Williams.;Emilia Bagiella.;Robert E Michler.;Richard D Weisel.;Marissa A Miller.;Nancy L Geller.;Wendy C Taddei-Peters.;Peter K Smith.;Ellen Moquete.;Jessica R Overbey.;Irving L Kron.;Patrick T O'Gara.;Michael A Acker.; .
来源: N Engl J Med. 2016年374卷4期344-53页
In a randomized trial comparing mitral-valve repair with mitral-valve replacement in patients with severe ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI), survival, or adverse events at 1 year after surgery. However, patients in the repair group had significantly more recurrences of moderate or severe mitral regurgitation. We now report the 2-year outcomes of this trial.
204. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.
作者: Margaret M Redfield.;Kevin J Anstrom.;James A Levine.;Gabe A Koepp.;Barry A Borlaug.;Horng H Chen.;Martin M LeWinter.;Susan M Joseph.;Sanjiv J Shah.;Marc J Semigran.;G Michael Felker.;Robert T Cole.;Gordon R Reeves.;Ryan J Tedford.;W H Wilson Tang.;Steven E McNulty.;Eric J Velazquez.;Monica R Shah.;Eugene Braunwald.; .
来源: N Engl J Med. 2015年373卷24期2314-24页
Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients.
205. Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate.
作者: Morgan E Grams.;Yingying Sang.;Andrew S Levey.;Kunihiro Matsushita.;Shoshana Ballew.;Alex R Chang.;Eric K H Chow.;Bertram L Kasiske.;Csaba P Kovesdy.;Girish N Nadkarni.;Varda Shalev.;Dorry L Segev.;Josef Coresh.;Krista L Lentine.;Amit X Garg.; .
来源: N Engl J Med. 2016年374卷5期411-21页
Evaluation of candidates to serve as living kidney donors relies on screening for individual risk factors for end-stage renal disease (ESRD). To support an empirical approach to donor selection, we developed a tool that simultaneously incorporates multiple health characteristics to estimate a person's probable long-term risk of ESRD if that person does not donate a kidney.
207. Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.
作者: Thomas H Inge.;Anita P Courcoulas.;Todd M Jenkins.;Marc P Michalsky.;Michael A Helmrath.;Mary L Brandt.;Carroll M Harmon.;Meg H Zeller.;Mike K Chen.;Stavra A Xanthakos.;Mary Horlick.;C Ralph Buncher.; .
来源: N Engl J Med. 2016年374卷2期113-23页
Bariatric surgery is increasingly considered for the treatment of adolescents with severe obesity, but few prospective adolescent-specific studies examining the efficacy and safety of weight-loss surgery are available to support clinical decision making.
209. Soluble Urokinase Receptor and Chronic Kidney Disease.
作者: Salim S Hayek.;Sanja Sever.;Yi-An Ko.;Howard Trachtman.;Mosaab Awad.;Shikha Wadhwani.;Mehmet M Altintas.;Changli Wei.;Anna L Hotton.;Audrey L French.;Laurence S Sperling.;Stamatios Lerakis.;Arshed A Quyyumi.;Jochen Reiser.
来源: N Engl J Med. 2015年373卷20期1916-25页
Relatively high plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor clinical outcomes in patients with various conditions. It is unknown whether elevated suPAR levels in patients with normal kidney function are associated with future decline in the estimated glomerular filtration rate (eGFR) and with incident chronic kidney disease.
214. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
作者: .;W Marston Linehan.;Paul T Spellman.;Christopher J Ricketts.;Chad J Creighton.;Suzanne S Fei.;Caleb Davis.;David A Wheeler.;Bradley A Murray.;Laura Schmidt.;Cathy D Vocke.;Myron Peto.;Abu Amar M Al Mamun.;Eve Shinbrot.;Anurag Sethi.;Samira Brooks.;W Kimryn Rathmell.;Angela N Brooks.;Katherine A Hoadley.;A Gordon Robertson.;Denise Brooks.;Reanne Bowlby.;Sara Sadeghi.;Hui Shen.;Daniel J Weisenberger.;Moiz Bootwalla.;Stephen B Baylin.;Peter W Laird.;Andrew D Cherniack.;Gordon Saksena.;Scott Haake.;Jun Li.;Han Liang.;Yiling Lu.;Gordon B Mills.;Rehan Akbani.;Mark D M Leiserson.;Benjamin J Raphael.;Pavana Anur.;Donald Bottaro.;Laurence Albiges.;Nandita Barnabas.;Toni K Choueiri.;Bogdan Czerniak.;Andrew K Godwin.;A Ari Hakimi.;Thai H Ho.;James Hsieh.;Michael Ittmann.;William Y Kim.;Bhavani Krishnan.;Maria J Merino.;Kenna R Mills Shaw.;Victor E Reuter.;Ed Reznik.;Carl S Shelley.;Brian Shuch.;Sabina Signoretti.;Ramaprasad Srinivasan.;Pheroze Tamboli.;George Thomas.;Satish Tickoo.;Kenneth Burnett.;Daniel Crain.;Johanna Gardner.;Kevin Lau.;David Mallery.;Scott Morris.;Joseph D Paulauskis.;Robert J Penny.;Candace Shelton.;W Troy Shelton.;Mark Sherman.;Eric Thompson.;Peggy Yena.;Melissa T Avedon.;Jay Bowen.;Julie M Gastier-Foster.;Mark Gerken.;Kristen M Leraas.;Tara M Lichtenberg.;Nilsa C Ramirez.;Tracie Santos.;Lisa Wise.;Erik Zmuda.;John A Demchok.;Ina Felau.;Carolyn M Hutter.;Margi Sheth.;Heidi J Sofia.;Roy Tarnuzzer.;Zhining Wang.;Liming Yang.;Jean C Zenklusen.;Jiashan Zhang.;Brenda Ayala.;Julien Baboud.;Sudha Chudamani.;Jia Liu.;Laxmi Lolla.;Rashi Naresh.;Todd Pihl.;Qiang Sun.;Yunhu Wan.;Ye Wu.;Adrian Ally.;Miruna Balasundaram.;Saianand Balu.;Rameen Beroukhim.;Tom Bodenheimer.;Christian Buhay.;Yaron S N Butterfield.;Rebecca Carlsen.;Scott L Carter.;Hsu Chao.;Eric Chuah.;Amanda Clarke.;Kyle R Covington.;Mahmoud Dahdouli.;Ninad Dewal.;Noreen Dhalla.;Harsha V Doddapaneni.;Jennifer A Drummond.;Stacey B Gabriel.;Richard A Gibbs.;Ranabir Guin.;Walker Hale.;Alicia Hawes.;D Neil Hayes.;Robert A Holt.;Alan P Hoyle.;Stuart R Jefferys.;Steven J M Jones.;Corbin D Jones.;Divya Kalra.;Christie Kovar.;Lora Lewis.;Jie Li.;Yussanne Ma.;Marco A Marra.;Michael Mayo.;Shaowu Meng.;Matthew Meyerson.;Piotr A Mieczkowski.;Richard A Moore.;Donna Morton.;Lisle E Mose.;Andrew J Mungall.;Donna Muzny.;Joel S Parker.;Charles M Perou.;Jeffrey Roach.;Jacqueline E Schein.;Steven E Schumacher.;Yan Shi.;Janae V Simons.;Payal Sipahimalani.;Tara Skelly.;Matthew G Soloway.;Carrie Sougnez.;Angela Tam.;Donghui Tan.;Nina Thiessen.;Umadevi Veluvolu.;Min Wang.;Matthew D Wilkerson.;Tina Wong.;Junyuan Wu.;Liu Xi.;Jane Zhou.;Jason Bedford.;Fengju Chen.;Yao Fu.;Mark Gerstein.;David Haussler.;Katayoon Kasaian.;Phillip Lai.;Shiyun Ling.;Amie Radenbaugh.;David Van Den Berg.;John N Weinstein.;Jingchun Zhu.;Monique Albert.;Iakovina Alexopoulou.;Jeremiah J Andersen.;J Todd Auman.;John Bartlett.;Sheldon Bastacky.;Julie Bergsten.;Michael L Blute.;Lori Boice.;Roni J Bollag.;Jeff Boyd.;Erik Castle.;Ying-Bei Chen.;John C Cheville.;Erin Curley.;Benjamin Davies.;April DeVolk.;Rajiv Dhir.;Laura Dike.;John Eckman.;Jay Engel.;Jodi Harr.;Ronald Hrebinko.;Mei Huang.;Lori Huelsenbeck-Dill.;Mary Iacocca.;Bruce Jacobs.;Michael Lobis.;Jodi K Maranchie.;Scott McMeekin.;Jerome Myers.;Joel Nelson.;Jeremy Parfitt.;Anil Parwani.;Nicholas Petrelli.;Brenda Rabeno.;Somak Roy.;Andrew L Salner.;Joel Slaton.;Melissa Stanton.;R Houston Thompson.;Leigh Thorne.;Kelinda Tucker.;Paul M Weinberger.;Cynthia Winemiller.;Leigh Anne Zach.;Rosemary Zuna.
来源: N Engl J Med. 2016年374卷2期135-45页
Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell carcinomas, is a heterogeneous disease that consists of various types of renal cancer, including tumors with indolent, multifocal presentation and solitary tumors with an aggressive, highly lethal phenotype. Little is known about the genetic basis of sporadic papillary renal-cell carcinoma, and no effective forms of therapy for advanced disease exist.
217. Bradyarrhythmias Associated with Sofosbuvir Treatment.
作者: Hélène Fontaine.;Arnaud Lazarus.;Stanislas Pol.;Caroline Pecriaux.;François Bagate.;Philippe Sultanik.;Estelle Boueyre.;Marion Corouge.;Vincent Mallet.;Anaïs Vallet-Pichard.;Philippe Sogni.;Denis Duboc.; .
来源: N Engl J Med. 2015年373卷19期1886-8页 |