Seventy per cent of patients with cancer have evidence of metastases and spinal involvement may occur in up to 50 %. Pain is the most frequent symptom and it occurs in 90 % of the patients. It exist three different type of spinal pain : inflammatory, radicular and mechanical pain. Pain could be related to a neurological compromise and treatment becomes urgent. Steroids are introduced even if surgery is indicated. The Spinal Instability Neoplastic Score is a useful tool in order to determine instability in spinal metastases. Early recognition of instability could allow to minimal invasive surgery and even vertebroplasty. Tokuhashi score facilitates patient's selection during the decision-making process to the multidisciplinary team.

Subsolid nodules represent almost 20% of all pulmonary nodules found incidentally at chest computed tomography (CT). Their detection is steadily rising, in parallel with the increasing number of CT scans performed. Subsolid nodules differ from solid lung nodules in several ways: morphology, course of progression, risk of malignancy and prognosis. Although they remain a diagnostic challenge, a good correlation has been established between radiological appearance and histopathology. Whilst 75% of persistent subsolid nodules represent a form of adenocarcinoma, their prognosis is generally excellent when resected. Non-resected subsolid nodules require a long follow-up of 3 to 5 years due to their slow-growing nature and high prevalence of malignancy. Specific guidelines have been published in 2013 and in 2015.

Reflectance confocal microscopy is a non invasive imaging technique which provides in vivo and real time images of different skin tissues with a resolution close to histology, however with a depth limited to superficial dermis.The first lesions that were morphologically analyzed are melanocytic lesions. Reflectance confocal microscopy has been used for about ten years in dermatology. Its progressive improvement over the years has allowed it to be an efficient tool for diagnosing cutaneous tumors. It has been developed for inflammatory dermatosis, cutaneous infections, angiomas, cosmetology. Furthermore, it is also used to delimit the edges of lesions or the area to biopsy. This cutaneous imaging technique represents a major innovation and has its place in dermatological practice.

Invasive breast cancer is the most common malignancy in women in industrialized countries. Three-quarters of breast cancers express estrogen and/or progesterone receptors and are considered endocrine-sensitive. Endocrine therapy reduces the risk of loco-regional, contralateral and distant recurrence. The management has become more complex with estrogen receptor inhibitors, aromatase inhibitors and ovarian function suppression. The choice of the regimen and its duration depend on the age, the menopausal status of the patient, her co-morbidities, the risk of cancer relapse and the tolerance. We summarize here the recent modifications of the endocrine therapy in early and advanced stage breast cancer.

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as breakthroughs in the lay press and by some medical opinion leaders. Unfortunately, the use of inflated descriptors of the drug efficacy leads to misunderstandings among the clinicians in charge of patients. Currently, vemurafenib, ipilimumab, pembrolizumab and nivolumab have demonstrated their relative activity in the control of advanced malignant melanoma. The results expected from surrogate markers of efficacy are magnified and idealized regarding the expectations from many patients. The recent therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the current beneficial effects.

Pituitary metastasis occur in 1-5 % of patients with cancer. We report the discovery of a unique pituitary metastasis of breast cancer. A 67 years old woman was treated in 2003 for local adenocarcinoma. After bone metastatic relapse in 2008, the patient developed diplopia and diabetes insipidus. An MRI revealed a histologically proven metastatic pituitary nodule. Further explorations revealed failure of multiple endocrine axes. Pituitary metastases are relatively rare, but are probably under-diagnosed in the presence of advanced cancers with impaired general condition. This diagnosis should be considered in the context of cancer patients, with a recent history of diabetes insipidus, especially if the latter is associated with other neurological signs (ophthalmoplegia, cephallagia).

Liposarcoma is an extremely rare malignant adipose mesenchymal tumor. World Health Organization classifies liposarcomas into five subtypes: well differentiated, myxoid, pleomorphic, dedifferentiated and mixed. The association between multiple and synchronous location of several subtypes of liposarcomas is exceptional. Only 34 cases have been reported in the literature. We report the case of synchronous association between retroperitoneal dedifferentiated liposarcoma and two small well-differentiated lipoma-like pericolic liposarcomas. Anatomopathological aspects, therapeutic options and prognostic factors of liposarcomas have been reviewed in this study.

Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the literature, except for two studies. The aim of this case study was to better identify and clarify the role of dermoscopy in the diagnosis of BSC, although histological confirmation is necessary.

Primary extra-ganglionic non-Hodgkin's lymphoma (NHL) is rare and its primary intramuscular location is exceptional, as it account for less than 0.5% of all patients. It generally affects men, with an average age of 70 years. Standard treatment is based on surgical excision combined with chemotherapy and radiation therapy. We report the case of a 31-year old patient presenting with muscular pseudotumoral syndrome at the level of the right leg. Histological examination showed intramuscular large B-cell non-Hodgkin's lymphoma. The patient underwent exclusive chemotherapy with complete remission.

Solitary plasmocytomas are rare, accounting for less than 5% of all plasmocytes proliferations. Its diagnosis is based on the presence of localized tumor of monoclonal plasma cells cytologically identical to those of multiple myeloma, in the absence of other signs of a disseminated form. This study aims to carry out a retrospective study of three cases of solitary bone plasmocytomas associated with a detailed review of the literature describing the diagnostic, therapeutic and evolving characteristics of this rare entity.

Primitive large cell neuroendocrine tumor of the breast is an extremely rare entity. Less than ten cases have been reported in the literature. We report a new case of a 61-year old male patient presenting with locally advanced tumor of the right breast, immediately metastasized to the lungs and pleura, staged cT4bN1M1. The patient received eight cycles of Docetaxel-based chemotherapy every 21 days, with a good clinical and radiological response (>50%), followed by adjuvant tamoxifen with disease stabilization for 18 months. Immunohistochemistry is still essential to determine the neuroendocrine nature of this tumor. Treatment is not well codified due to the rarity of this type of cancer.

Peritoneal tuberculosis is a curable infectious disease that can simulate advanced ovarian cancer, leading to extensive and unnecessary surgical procedures commonly performed on women of reproductive age. We report a new case of pseudo-tumoral peritoneal tuberculosis in a 43-year old female patient with suspected ovarian cancer associated with peritoneal carcinomatosis. The diagnosis of peritoneal tuberculosis was based on exploratory laparotomy with extemporaneous histological examination. The patient responded well to anti-tuberculosis treatment according to 2ERHZ/4RH protocol.

Cervicothoracic cystic lymphangiomas are rare benign tumors developing from sequestration of embryonic lymph sac which is gradually filled with lymph fluid. The diagnosis is based on clinical signs (laterocervical swelling) and imaging (ultrasound and CT scan), then confirmed by histology after surgery which constitutes the basis of treatment. We here report a case of cervicothoracic cystic lymphangioma and review of the literature.

Nodular liver lesions mainly consist of tumors. Solitary necrotic nodule of the liver is rare. Preoperative diagnosis is difficult. We report the case of a 43-year old woman undergoing surgery for the treatment of a rectal adenocarcinoma metastatized to the liver. Abdominal CT scan showed liver nodule mimicking liver metastasis. The second case is that of a 56 year-old man undergoing cholecystectomy in whom a liver nodule was detected intraoperatively. In both cases, liver nodule was subcapsular and was resected. Anatomopathological examination allowed the diagnosis of solitary necrotic nodule of the liver. Nonspecific necrotic nodule of the liver should be suspected in liver lesions, even in neoplastic context. Characterization using imaging studies and puncture biopsy of liver lesions can be useful.

Renal angiomyolipoma is a benign renal tumor with a fatty component. We here report a series of 8 cases in order to describe diagnostic criteria and management options for renal angiomyolipoma. We studied 8 cases of renal angiomyolipomas over a 4-year period. All patients underwent ultrasound and abdominal CT scan. The diagnosis was confirmed on the basis of imaging data in all the cases. Two patients had been treated for Bourneville's tuberous sclerosis since childhood. The average age was 42 years. Ultrasound showed a hypoechoic heterogeneous aspect in all the cases. CT scan allowed the detection of the fatty component. Radiological diagnosis of renal angiomyolipoma is mainly based on the detection of the fatty component. Its association with Bourneville's tuberous sclerosis is an additional diagnostic argument.

Solitary fibrous tumors of the female genital tract are extremely rare. We report the case of a 78-year old patient presenting with a pelvic mass. Surgical exploration showed parauterine tumor. Anatomo-pathological examination confirmed the diagnosis of malignant solitary fibrous tumor. The evolution was marked by the death of the patient. It is important to be able to detect these tumors whose evolution can be poor. Long-term follow-up of patients with resectable tumor should be recommended.

Rhabdomyosarcoma of the uterine cervix is a rare histological type of cervical cancer, occurring commonly in young girls or sexually active women. Given the aggressiveness of the disease, therapeutic strategy is based on the combination of the three treatment modalities (chemotherapy - radiation therapy-surgery). We report the case of a 20-year old patient with rhabdomyosarcoma of the uterine cervix. The patient had a personal history of recurrent genital infections. Patient's first symptom was profuse metrorrhagias associated with the presence of a mass like "a bunch of grapes". Biopsy was in favor of a rhabdomyosarcoma of the uterine cervix. E Extension assessment showed locally advanced mass without metastasis. The patient underwent 5 administrations of VAC chemotherapy, exhibiting tumor regression of 90%. She underwent hysterectomy without adnexal conservation. Then she received postoperative pelvic radiation therapy. At 13-months' follow-up the patient was still in complete remission. Rhabdomyosarcoma of the uterine cervix is a rare tumor that develops most often in young girls. It mainly shows locoregional extension. Treatment is based on surgery including conservative treatment as well as radical treatment associated with perioperative chemotherapy. The role of radiation therapy remains poorly defined.