1922. Mortality in biopsy-proven alcohol-related liver disease: a population-based nationwide cohort study of 3453 patients.
作者: Hannes Hagström.;Maja Thiele.;Bjorn Roelstraete.;Jonas Söderling.;Jonas F Ludvigsson.
来源: Gut. 2021年70卷1期170-179页
Patients with alcohol-related liver disease (ALD) are at increased risk of death, but studies have rarely investigated the significance of histological severity or estimated relative risks compared with a general population. We examined mortality in a nationwide cohort of biopsy-proven ALD.
1923. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.
作者: Frank Jühling.;Nourdine Hamdane.;Emilie Crouchet.;Shen Li.;Houssein El Saghire.;Atish Mukherji.;Naoto Fujiwara.;Marine A Oudot.;Christine Thumann.;Antonio Saviano.;Armando Andres Roca Suarez.;Kaku Goto.;Ricard Masia.;Mozhdeh Sojoodi.;Gunisha Arora.;Hiroshi Aikata.;Atsushi Ono.;Parissa Tabrizian.;Myron Schwartz.;Stephen J Polyak.;Irwin Davidson.;Christian Schmidl.;Christoph Bock.;Catherine Schuster.;Kazuaki Chayama.;Patrick Pessaux.;Kenneth K Tanabe.;Yujin Hoshida.;Mirjam B Zeisel.;François Ht Duong.;Bryan C Fuchs.;Thomas F Baumert.
来源: Gut. 2021年70卷1期157-169页
Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory and chemopreventive approaches are absent. Chronic hepatitis C (CHC) results in epigenetic alterations driving HCC risk and persisting following cure. Here, we aimed to investigate epigenetic modifications as targets for liver cancer chemoprevention.
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