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1901. Age independent survival benefit for patients with hepatocellular carcinoma (HCC) without metastases at diagnosis: a population-based study.
作者: Enrico N De Toni.;Anne Schlesinger-Raab.;Martin Fuchs.;Wolfgang Schepp.;Ursula Ehmer.;Fabian Geisler.;Jens Ricke.;Philipp Paprottka.;Helmut Friess.;Jens Werner.;Alexander L Gerbes.;Julia Mayerle.;Jutta Engel.
来源: Gut. 2020年69卷1期168-176页
Hepatocellular carcinoma (HCC) is a major cause of death worldwide and its incidence is expected to increase globally. Aim of this study was to assess whether the implementation of screening policies and the improvement of treatment options translated into a real-world survival benefit in HCC patients.
1902. Most unambiguous loss-of-function CPA1 mutations are unlikely to predispose to chronic pancreatitis.
作者: Jin-Huan Lin.;Arnaud Boulling.;Emmanuelle Masson.;David N Cooper.;Zhao-Shen Li.;Claude Férec.;Zhuan Liao.;Jian-Min Chen.
来源: Gut. 2020年69卷4期785-786页 1903. Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets.
作者: Eloi R Verrier.;Amélie Weiss.;Charlotte Bach.;Laura Heydmann.;Vincent Turon-Lagot.;Arnaud Kopp.;Houssein El Saghire.;Emilie Crouchet.;Patrick Pessaux.;Thomas Garcia.;Patrick Pale.;Mirjam B Zeisel.;Camille Sureau.;Catherine Schuster.;Laurent Brino.;Thomas F Baumert.
来源: Gut. 2020年69卷1期158-167页
Hepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent.
1909. Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis.
作者: Yukari Kato.;Keishiro Azuma.;Hitoshi Someda.;Masahiro Shiokawa.;Tsutomu Chiba.
来源: Gut. 2020年69卷3期607-609页 1911. TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function.
作者: Grégory Merlen.;Nicolas Kahale.;Jose Ursic-Bedoya.;Valeska Bidault-Jourdainne.;Hayat Simerabet.;Isabelle Doignon.;Zahra Tanfin.;Isabelle Garcin.;Noémie Péan.;Julien Gautherot.;Anne Davit-Spraul.;Catherine Guettier.;Lydie Humbert.;Dominique Rainteau.;Klaus Ebnet.;Christoph Ullmer.;Doris Cassio.;Thierry Tordjmann.
来源: Gut. 2020年69卷1期146-157页
We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the regulation of biliary epithelium permeability.
1912. Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants.
作者: Tenghao Zheng.;Shanti Eswaran.;Amanda L Photenhauer.;Juanita L Merchant.;William D Chey.;Mauro D'Amato.
来源: Gut. 2020年69卷2期397-398页 1914. Follow-on rifaximin for the prevention of recurrence following standard treatment of infection with Clostridium difficile: a competing risks analysis provides a full picture of possible treatment effects.1917. Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction.
作者: Joeri Tulkens.;Glenn Vergauwen.;Jan Van Deun.;Edward Geeurickx.;Bert Dhondt.;Lien Lippens.;Marie-Angélique De Scheerder.;Ilkka Miinalainen.;Pekka Rappu.;Bruno G De Geest.;Katrien Vandecasteele.;Debby Laukens.;Linos Vandekerckhove.;Hannelore Denys.;Jo Vandesompele.;Olivier De Wever.;An Hendrix.
来源: Gut. 2020年69卷1期191-193页 |