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1882. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
作者: Ningning Niu.;Ping Lu.;Yanlin Yang.;Ruizhe He.;Li Zhang.;Juanjuan Shi.;Jinghua Wu.;Minwei Yang.;Zhi-Gang Zhang.;Li-Wei Wang.;Wei-Qiang Gao.;Aida Habtezion.;Gary Guishan Xiao.;Yongwei Sun.;Li Li.;Jing Xue.
来源: Gut. 2020年69卷4期715-726页
SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown.
1883. Tight control for Crohn's disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial.
作者: Remo Panaccione.;Jean-Frederic Colombel.;Simon P L Travis.;Peter Bossuyt.;Filip Baert.;Tomáš Vaňásek.;Ahmet Danalıoğlu.;Gottfried Novacek.;Alessandro Armuzzi.;Walter Reinisch.;Scott Johnson.;Marric Buessing.;Ezequiel Neimark.;Joel Petersson.;Wan-Ju Lee.;Geert R D'Haens.
来源: Gut. 2020年69卷4期658-664页
To evaluate the cost-effectiveness of an inflammatory biomarker and clinical symptom directed tight control strategy (TC) compared with symptom-based clinical management (CM) in patients with Crohn's disease (CD) naïve to immunosuppressants and biologics using a UK public payer perspective.
1884. Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS.
作者: Alexander Queck.;Roberto Carnevale.;Frank Erhard Uschner.;Robert Schierwagen.;Sabine Klein.;Christian Jansen.;Carsten Meyer.;Michael Praktiknjo.;Daniel Thomas.;Christian Strassburg.;Stefan Zeuzem.;Francesco Violi.;Jonel Trebicka.
来源: Gut. 2020年69卷8期1535-1536页 1885. High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity.
作者: Natasja L de Vries.;Vincent van Unen.;Marieke E Ijsselsteijn.;Tamim Abdelaal.;Ruud van der Breggen.;Arantza Farina Sarasqueta.;Ahmed Mahfouz.;Koen C M J Peeters.;Thomas Höllt.;Boudewijn P F Lelieveldt.;Frits Koning.;Noel F C C de Miranda.
来源: Gut. 2020年69卷4期691-703页
A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of CRC.
1887. Alterations of the bile microbiome in primary sclerosing cholangitis.
作者: Timur Liwinski.;Roman Zenouzi.;Clara John.;Hanno Ehlken.;Malte C Rühlemann.;Corinna Bang.;Stefan Groth.;Wolfgang Lieb.;Marcus Kantowski.;Nils Andersen.;Guido Schachschal.;Tom H Karlsen.;Johannes R Hov.;Thomas Rösch.;Ansgar W Lohse.;Joerg Heeren.;Andre Franke.;Christoph Schramm.
来源: Gut. 2020年69卷4期665-672页
Patients with primary sclerosing cholangitis (PSC) display an altered colonic microbiome compared with healthy controls. However, little is known on the bile duct microbiome and its interplay with bile acid metabolism in PSC.
1888. Duration of organ failure impacts mortality in acute pancreatitis.
作者: Na Shi.;Tingting Liu.;Daniel de la Iglesia-Garcia.;Lihui Deng.;Tao Jin.;Lan Lan.;Ping Zhu.;Weiming Hu.;Zongguang Zhou.;Vikesh Singh.;J Enrique Dominguez-Munoz.;John Windsor.;Wei Huang.;Qing Xia.;Robert Sutton.
来源: Gut. 2020年69卷3期604-605页 1889. Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial.
作者: Grace L H Wong.;Louis H S Lau.;Jessica Y L Ching.;Yee-Kit Tse.;Rachel H Y Ling.;Vincent W S Wong.;Philip W Y Chiu.;James Y W Lau.;Francis K L Chan.
来源: Gut. 2020年69卷4期652-657页
Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding in such patients.
1890. First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene.
作者: Britt-Sabina Petersen.;Bernd Bokemeyer.;Christian Wenker.;Stefan Hoby.;Katrin Baumgartner.;Hermann Will.;Marc P Hoeppner.;Stefan Schreiber.;Ingo Mecklenburg.;Andre Franke.
来源: Gut. 2020年69卷6期1153-1154页 1892. Absence of hepatitis E virus RNA in semen samples of infertile male in China.
作者: Lin Wang.;Zhe Zhang.;Jingyi Shu.;Haitao Zhang.;Yuzhuo Yang.;Zhaochao Liang.;Qiyu He.;Weijin Huang.;Youchun Wang.;Hui Zhuang.;Hui Jiang.;Ling Wang.
来源: Gut. 2020年69卷7期1363-1364页 1893. Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer.
作者: Xiaobin Zheng.;Kana Wu.;Mingyang Song.;Shuji Ogino.;Charles S Fuchs.;Andrew T Chan.;Edward L Giovannucci.;Yin Cao.;Xuehong Zhang.
来源: Gut. 2020年69卷5期970-972页 1897. β6 integrinosis: a new lethal autosomal recessive ITGB6 disorder leading to impaired conformational transitions of the αVβ6 integrin receptor.
作者: Patrick Weil.;Rhea van den Bruck.;Thomas Ziegenhals.;Stefan Juranek.;Daniel Goedde.;Valerie Orth.;Stefan Wirth.;Andreas C Jenke.;Jan Postberg.
来源: Gut. 2020年69卷7期1359-1361页 1898. Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome.
作者: Sangeetha N Kalimuthu.;Gavin W Wilson.;Robert C Grant.;Matthew Seto.;Grainne O'Kane.;Rajkumar Vajpeyi.;Faiyaz Notta.;Steven Gallinger.;Runjan Chetty.
来源: Gut. 2020年69卷2期317-328页
Transcriptional analyses have identified several distinct molecular subtypes in pancreatic ductal adenocarcinoma (PDAC) that have prognostic and potential therapeutic significance. However, to date, an indepth, clinicomorphological correlation of these molecular subtypes has not been performed. We sought to identify specific morphological patterns to compare with known molecular subtypes, interrogate their biological significance, and furthermore reappraise the current grading system in PDAC.
1899. Alterations of gut microbiome in autoimmune hepatitis.
作者: Yiran Wei.;Yanmei Li.;Li Yan.;Chunyan Sun.;Qi Miao.;Qixia Wang.;Xiao Xiao.;Min Lian.;Bo Li.;Yong Chen.;Jun Zhang.;You Li.;Bingyuan Huang.;Yikang Li.;Qin Cao.;Zhuping Fan.;Xiaoyu Chen.;Jing-Yuan Fang.;Merrill Eric Gershwin.;Ruqi Tang.;Xiong Ma.
来源: Gut. 2020年69卷3期569-577页
The significance of the liver-microbiome axis has been increasingly recognised as a major modulator of autoimmunity. The aim of this study was to take advantage of a large well-defined corticosteroids treatment-naïve group of patients with autoimmune hepatitis (AIH) to rigorously characterise gut dysbiosis compared with healthy controls.
1900. Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study.
作者: Sanjay K Murthy.;Jahanara Begum.;Eric I Benchimol.;Charles N Bernstein.;Gilaad G Kaplan.;Jeffrey D McCurdy.;Harminder Singh.;Laura Targownik.;Monica Taljaard.
来源: Gut. 2020年69卷2期274-282页
To better understand the real-world impact of biologic therapy in persons with Crohn's disease (CD) and ulcerative colitis (UC), we evaluated the effect of marketplace introduction of infliximab on the population rates of hospitalisations and surgeries and public payer drug costs.
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