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1861. Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa.
作者: Laura Reyes-Uribe.;Wenhui Wu.;Ozkan Gelincik.;Prashant V Bommi.;Alejandro Francisco-Cruz.;Luisa M Solis.;Patrick M Lynch.;Ramona Lim.;Elena M Stoffel.;Priyanka Kanth.;N Jewel Samadder.;Maureen E Mork.;Melissa W Taggart.;Ginger L Milne.;Lawrence J Marnett.;Lana Vornik.;Diane D Liu.;Maria Revuelta.;Kyle Chang.;Y Nancy You.;Levy Kopelovich.;Ignacio I Wistuba.;J Jack Lee.;Shizuko Sei.;Robert H Shoemaker.;Eva Szabo.;Ellen Richmond.;Asad Umar.;Marjorie Perloff.;Powel H Brown.;Steven M Lipkin.;Eduardo Vilar.
来源: Gut. 2021年70卷3期555-566页
Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity and discover novel molecular pathways involved in the activity of naproxen as primary and secondary chemoprevention in patients with LS.
1865. GI symptoms and fever increase the risk of severe illness and death in patients with COVID-19.
作者: Jue Liu.;Liyuan Tao.;Xia Liu.;Hongyan Yao.;Shicheng Yu.;Qiqi Wang.;Jiaojiao Zhang.;Zhancheng Gao.;Rongmeng Jiang.;Wenzhan Jing.;Min Liu.
来源: Gut. 2021年70卷2期442-444页 1867. Loss of hepatic Mboat7 leads to liver fibrosis.
作者: Veera Raghavan Thangapandi.;Oskar Knittelfelder.;Mario Brosch.;Eleonora Patsenker.;Olga Vvedenskaya.;Stephan Buch.;Sebastian Hinz.;Alexander Hendricks.;Marina Nati.;Alexander Herrmann.;Devavrat Ravindra Rekhade.;Thomas Berg.;Madlen Matz-Soja.;Klaus Huse.;Edda Klipp.;Josch K Pauling.;Judith Ah Wodke.;Jacobo Miranda Ackerman.;Malte von Bonin.;Elmar Aigner.;Christian Datz.;Witigo von Schönfels.;Sophie Nehring.;Sebastian Zeissig.;Christoph Röcken.;Andreas Dahl.;Triantafyllos Chavakis.;Felix Stickel.;Andrej Shevchenko.;Clemens Schafmayer.;Jochen Hampe.;Pallavi Subramanian.
来源: Gut. 2021年70卷5期940-950页
The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including non-alcoholic fatty liver disease (NAFLD), alcohol-related liver disease, hepatitis B and C. We aim to understand the mechanism by which the rs641738C>T variant contributes to pathogenesis of NAFLD.
1868. Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study.
作者: Bing Zhang.;Hohui E Wang.;Ya-Mei Bai.;Shih-Jen Tsai.;Tung-Ping Su.;Tzeng-Ji Chen.;Yen-Po Wang.;Mu-Hong Chen.
来源: Gut. 2021年70卷1期85-91页
Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the 'gut-brain axis'. Recent findings suggest a connection between IBD and development of Parkinson's disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.
1871. Management strategies for the colonoscopic surveillance of people with Lynch syndrome during the COVID-19 pandemic.
作者: Kevin J Monahan.;Anne Lincoln.;James E East.;Sally Benton.;John Burn.;Bianca DeSouza.;Helen Hanson.;Fiona Lalloo.;Terri McVeigh.;Matthew D Rutter.;Katie Snape.;Huw J W Thomas.;Peter Sasieni.
来源: Gut. 2021年70卷3期624-626页 1872. Risk factors in patients with COVID-19 developing severe liver injury during hospitalisation.
作者: Ke Zhan.;Shengtao Liao.;Jinfang Li.;Yang Bai.;Lin Lv.;Keqi Yu.;Liewang Qiu.;Chuanfei Li.;Guodan Yuan.;An Zhang.;Zhechuan Mei.
来源: Gut. 2021年70卷3期628-629页 1873. Naturally occurring 5' preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C.
作者: Jing Li.;Jisu Li.;Shiqi Chen.;Quan Yuan.;Jing Zhang.;Jingwen Wu.;Qirong Jiang.;Qianru Wang.;Ning-Shao Xia.;Jiming Zhang.;Shuping Tong.
来源: Gut. 2021年70卷3期575-584页
Deletion of 15-nucleotide or 18-nucleotide (nt) covering preS1 ATG frequently arises during chronic infection with HBV genotypes B and C. Since the second ATG is 33nt downstream, they truncate large (L) envelope protein by 11 residues like wild-type genotype D. This study characterised their functional consequences.
1874. Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium.
作者: Ozge Kayisoglu.;Franziska Weiss.;Carolin Niklas.;Isabella Pierotti.;Malvika Pompaiah.;Nina Wallaschek.;Christoph-Thomas Germer.;Armin Wiegering.;Sina Bartfeld.
来源: Gut. 2021年70卷4期687-697页
The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear.
1876. International trends in oesophageal cancer survival by histological subtype between 1995 and 2014.
作者: Eileen Morgan.;Isabelle Soerjomataram.;Anna T Gavin.;Mark J Rutherford.;Piers Gatenby.;Aude Bardot.;Jacques Ferlay.;Oliver Bucher.;Prithwish De.;Gerda Engholm.;Christopher Jackson.;Serena Kozie.;Alana Little.;Bjorn Møller.;Lorraine Shack.;Hanna Tervonen.;Vicky Thursfield.;Sally Vernon.;Paul M Walsh.;Ryan R Woods.;Christian Finley.;Neil Merrett.;Dianne L O'Connell.;John V Reynolds.;Freddie Bray.;Melina Arnold.
来源: Gut. 2021年70卷2期234-242页
Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).
1877. Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1.
作者: Arnaud Köhler.;Sandrine Delbauve.;Justine Smout.;David Torres.;Véronique Flamand.
来源: Gut. 2021年70卷3期511-521页
Induction of immune protection against pathogens is particularly crucial during the neonatal period dominated by anti-inflammatory and tolerance immunity. The preclinical study was carried out to determine whether environmental factors such as microbiota may influence early life immunity by impacting the development and the functional maturation of precursors of type 1 conventional dendritic cells (pre-cDC1), endowed with regulatory properties.
1878. Ranking microbiome variance in inflammatory bowel disease: a large longitudinal intercontinental study.
作者: Adam G Clooney.;Julia Eckenberger.;Emilio Laserna-Mendieta.;Kathryn A Sexton.;Matthew T Bernstein.;Kathy Vagianos.;Michael Sargent.;Feargal J Ryan.;Carthage Moran.;Donal Sheehan.;Roy D Sleator.;Laura E Targownik.;Charles N Bernstein.;Fergus Shanahan.;Marcus J Claesson.
来源: Gut. 2021年70卷3期499-510页
The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional variability of the gut microbiota is unclear.
1879. Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
作者: Min Zhang.;Shuofeng Hu.;Min Min.;Yanli Ni.;Zheng Lu.;Xiaotian Sun.;Jiaqi Wu.;Bing Liu.;Xiaomin Ying.;Yan Liu.
来源: Gut. 2021年70卷3期464-475页
Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq).
1880. SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.
作者: Lea Južnić.;Kenneth Peuker.;Anne Strigli.;Mario Brosch.;Alexander Herrmann.;Robert Häsler.;Michael Koch.;Liz Matthiesen.;Yvonne Zeissig.;Britt-Sabina Löscher.;Alexander Nuber.;Gunnar Schotta.;Volker Neumeister.;Triantafyllos Chavakis.;Thomas Kurth.;Mathias Lesche.;Andreas Dahl.;Anne von Mässenhausen.;Andreas Linkermann.;Stefan Schreiber.;Konrad Aden.;Philip C Rosenstiel.;Andre Franke.;Jochen Hampe.;Sebastian Zeissig.
来源: Gut. 2021年70卷3期485-498页
The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the role of SET Domain Bifurcated Histone Lysine Methyltransferase 1, also known as ESET (SETDB1), a histone H3K9 methyltransferase, in intestinal epithelial homeostasis and IBD.
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