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1846. Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.
作者: Korsuk Sirinukunwattana.;Enric Domingo.;Susan D Richman.;Keara L Redmond.;Andrew Blake.;Clare Verrill.;Simon J Leedham.;Aikaterini Chatzipli.;Claire Hardy.;Celina M Whalley.;Chieh-Hsi Wu.;Andrew D Beggs.;Ultan McDermott.;Philip D Dunne.;Angela Meade.;Steven M Walker.;Graeme I Murray.;Leslie Samuel.;Matthew Seymour.;Ian Tomlinson.;Phil Quirke.;Timothy Maughan.;Jens Rittscher.;Viktor H Koelzer.; .
来源: Gut. 2021年70卷3期544-554页
Complex phenotypes captured on histological slides represent the biological processes at play in individual cancers, but the link to underlying molecular classification has not been clarified or systematised. In colorectal cancer (CRC), histological grading is a poor predictor of disease progression, and consensus molecular subtypes (CMSs) cannot be distinguished without gene expression profiling. We hypothesise that image analysis is a cost-effective tool to associate complex features of tissue organisation with molecular and outcome data and to resolve unclassifiable or heterogeneous cases. In this study, we present an image-based approach to predict CRC CMS from standard H&E sections using deep learning.
1847. Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study.
作者: Chun-Han Lo.;Sohee Kwon.;Liang Wang.;Georgios Polychronidis.;Markus D Knudsen.;Rong Zhong.;Yin Cao.;Kana Wu.;Shuji Ogino.;Edward L Giovannucci.;Andrew T Chan.;Mingyang Song.
来源: Gut. 2021年70卷3期620-621页 1848. Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a National Endoscopy Database Analysis.
作者: Matthew D Rutter.;Matthew Brookes.;Thomas J Lee.;Peter Rogers.;Linda Sharp.
来源: Gut. 2021年70卷3期537-543页
The COVID-19 pandemic has had a major global impact on endoscopic services. This reduced capacity, along with public reluctance to undergo endoscopy during the pandemic, might result in excess mortality from delayed cancer diagnosis. Using the UK's National Endoscopy Database (NED), we performed the first national analysis of the impact of the pandemic on endoscopy services and endoscopic cancer diagnosis.
1849. Non-nucleatum Fusobacterium species are dominant in the Southern Chinese population with distinctive correlations to host diseases compared with F. nucleatum.
作者: Yan He.;Prabhakar Mujagond.;Wenli Tang.;Wei Wu.;Huimin Zheng.;Xia Chen.;Muxuan Chen.;Wenjun Ma.;Guanghui Chen.;Hongwei Zhou.
来源: Gut. 2021年70卷4期810-812页 1850. Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19.
作者: Tao Zuo.;Qin Liu.;Fen Zhang.;Grace Chung-Yan Lui.;Eugene Yk Tso.;Yun Kit Yeoh.;Zigui Chen.;Siaw Shi Boon.;Francis Kl Chan.;Paul Ks Chan.;Siew C Ng.
来源: Gut. 2021年70卷2期276-284页
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in the GI tract during disease course is largely unknown. We investigated temporal transcriptional activity of SARS-CoV-2 and its association with longitudinal faecal microbiome alterations in patients with COVID-19.
1852. Involvement of liver in COVID-19: systematic review and meta-analysis.
作者: Dipesh Kumar Yadav.;Akanand Singh.;Qi Zhang.;Xueli Bai.;Wei Zhang.;Rajesh Kumar Yadav.;Alina Singh.;Li Zhiwei.;Vishnu Prasad Adhikari.;Tingbo Liang.
来源: Gut. 2021年70卷4期807-809页 1856. Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort.
作者: Jasmohan S Bajaj.;Guadalupe Garcia-Tsao.;Scott W Biggins.;Patrick S Kamath.;Florence Wong.;Sara McGeorge.;Jawaid Shaw.;Meredith Pearson.;Micheal Chew.;Andrew Fagan.;Randolph de la Rosa Rodriguez.;Janelle Worthington.;Amy Olofson.;Vanessa Weir.;Calvin Trisolini.;Sarah Dwyer.;K Rajender Reddy.
来源: Gut. 2021年70卷3期531-536页
Comorbid conditions are associated with poor prognosis in COVID-19. Registry data show that patients with cirrhosis may be at high risk. However, outcome comparisons among patients with cirrhosis+COVID-19 versus patients with COVID-19 alone and cirrhosis alone are lacking. The aim of this study was to perform these comparisons.
1857. Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
作者: Shixian Hu.;Arnau Vich Vila.;Ranko Gacesa.;Valerie Collij.;Christine Stevens.;Jack M Fu.;Isaac Wong.;Michael E Talkowski.;Manuel A Rivas.;Floris Imhann.;Laura Bolte.;Hendrik van Dullemen.;Gerard Dijkstra.;Marijn C Visschedijk.;Eleonora A Festen.;Ramnik J Xavier.;Jingyuan Fu.;Mark J Daly.;Cisca Wijmenga.;Alexandra Zhernakova.;Alexander Kurilshikov.;Rinse K Weersma.
来源: Gut. 2021年70卷2期285-296页
Both the gut microbiome and host genetics are known to play significant roles in the pathogenesis of IBD. However, the interaction between these two factors and its implications in the aetiology of IBD remain underexplored. Here, we report on the influence of host genetics on the gut microbiome in IBD.
1858. Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19.
作者: Terry Cheuk-Fung Yip.;Grace Chung-Yan Lui.;Vincent Wai-Sun Wong.;Viola Chi-Ying Chow.;Tracy Hang-Yee Ho.;Timothy Chun-Man Li.;Yee-Kit Tse.;David Shu-Cheong Hui.;Henry Lik-Yuen Chan.;Grace Lai-Hung Wong.
来源: Gut. 2021年70卷4期733-742页
Data on serial liver biochemistries of patients infected by different human coronaviruses (HCoVs) are lacking. The impact of liver injury on adverse clinical outcomes in coronavirus disease 2019 (COVID-19) patients remains unclear.
1859. Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa.
作者: Laura Reyes-Uribe.;Wenhui Wu.;Ozkan Gelincik.;Prashant V Bommi.;Alejandro Francisco-Cruz.;Luisa M Solis.;Patrick M Lynch.;Ramona Lim.;Elena M Stoffel.;Priyanka Kanth.;N Jewel Samadder.;Maureen E Mork.;Melissa W Taggart.;Ginger L Milne.;Lawrence J Marnett.;Lana Vornik.;Diane D Liu.;Maria Revuelta.;Kyle Chang.;Y Nancy You.;Levy Kopelovich.;Ignacio I Wistuba.;J Jack Lee.;Shizuko Sei.;Robert H Shoemaker.;Eva Szabo.;Ellen Richmond.;Asad Umar.;Marjorie Perloff.;Powel H Brown.;Steven M Lipkin.;Eduardo Vilar.
来源: Gut. 2021年70卷3期555-566页
Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity and discover novel molecular pathways involved in the activity of naproxen as primary and secondary chemoprevention in patients with LS.
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