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1821. Epidemiology of chronic liver diseases in the USA in the past three decades.
作者: Zobair M Younossi.;Maria Stepanova.;Youssef Younossi.;Pegah Golabi.;Alita Mishra.;Nila Rafiq.;Linda Henry.
来源: Gut. 2020年69卷3期564-568页
Given significant advances in treatment of viral hepatitis and the growing epidemic of obesity, the burden of the different types of liver diseases in the USA may be changing. Our aim was to assess the shift in the prevalence of different liver disease aetiologies in the USA over the past three decades.
1826. Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study.
作者: Annieke C G van Baar.;Frits Holleman.;Laurent Crenier.;Rehan Haidry.;Cormac Magee.;David Hopkins.;Leonardo Rodriguez Grunert.;Manoel Galvao Neto.;Paulina Vignolo.;Bu'Hussain Hayee.;Ann Mertens.;Raf Bisschops.;Jan Tijssen.;Max Nieuwdorp.;Caterina Guidone.;Guido Costamagna.;Jacques Devière.;Jacques J G H M Bergman.
来源: Gut. 2020年69卷2期295-303页
The duodenum has become a metabolic treatment target through bariatric surgery learnings and the specific observation that bypassing, excluding or altering duodenal nutrient exposure elicits favourable metabolic changes. Duodenal mucosal resurfacing (DMR) is a novel endoscopic procedure that has been shown to improve glycaemic control in people with type 2 diabetes mellitus (T2D) irrespective of body mass index (BMI) changes. DMR involves catheter-based circumferential mucosal lifting followed by hydrothermal ablation of duodenal mucosa. This multicentre study evaluates safety and feasibility of DMR and its effect on glycaemia at 24 weeks and 12 months.
1831. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
作者: Ningning Niu.;Ping Lu.;Yanlin Yang.;Ruizhe He.;Li Zhang.;Juanjuan Shi.;Jinghua Wu.;Minwei Yang.;Zhi-Gang Zhang.;Li-Wei Wang.;Wei-Qiang Gao.;Aida Habtezion.;Gary Guishan Xiao.;Yongwei Sun.;Li Li.;Jing Xue.
来源: Gut. 2020年69卷4期715-726页
SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown.
1832. Tight control for Crohn's disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial.
作者: Remo Panaccione.;Jean-Frederic Colombel.;Simon P L Travis.;Peter Bossuyt.;Filip Baert.;Tomáš Vaňásek.;Ahmet Danalıoğlu.;Gottfried Novacek.;Alessandro Armuzzi.;Walter Reinisch.;Scott Johnson.;Marric Buessing.;Ezequiel Neimark.;Joel Petersson.;Wan-Ju Lee.;Geert R D'Haens.
来源: Gut. 2020年69卷4期658-664页
To evaluate the cost-effectiveness of an inflammatory biomarker and clinical symptom directed tight control strategy (TC) compared with symptom-based clinical management (CM) in patients with Crohn's disease (CD) naïve to immunosuppressants and biologics using a UK public payer perspective.
1833. Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS.
作者: Alexander Queck.;Roberto Carnevale.;Frank Erhard Uschner.;Robert Schierwagen.;Sabine Klein.;Christian Jansen.;Carsten Meyer.;Michael Praktiknjo.;Daniel Thomas.;Christian Strassburg.;Stefan Zeuzem.;Francesco Violi.;Jonel Trebicka.
来源: Gut. 2020年69卷8期1535-1536页 1834. High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity.
作者: Natasja L de Vries.;Vincent van Unen.;Marieke E Ijsselsteijn.;Tamim Abdelaal.;Ruud van der Breggen.;Arantza Farina Sarasqueta.;Ahmed Mahfouz.;Koen C M J Peeters.;Thomas Höllt.;Boudewijn P F Lelieveldt.;Frits Koning.;Noel F C C de Miranda.
来源: Gut. 2020年69卷4期691-703页
A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of CRC.
1836. Alterations of the bile microbiome in primary sclerosing cholangitis.
作者: Timur Liwinski.;Roman Zenouzi.;Clara John.;Hanno Ehlken.;Malte C Rühlemann.;Corinna Bang.;Stefan Groth.;Wolfgang Lieb.;Marcus Kantowski.;Nils Andersen.;Guido Schachschal.;Tom H Karlsen.;Johannes R Hov.;Thomas Rösch.;Ansgar W Lohse.;Joerg Heeren.;Andre Franke.;Christoph Schramm.
来源: Gut. 2020年69卷4期665-672页
Patients with primary sclerosing cholangitis (PSC) display an altered colonic microbiome compared with healthy controls. However, little is known on the bile duct microbiome and its interplay with bile acid metabolism in PSC.
1837. Duration of organ failure impacts mortality in acute pancreatitis.
作者: Na Shi.;Tingting Liu.;Daniel de la Iglesia-Garcia.;Lihui Deng.;Tao Jin.;Lan Lan.;Ping Zhu.;Weiming Hu.;Zongguang Zhou.;Vikesh Singh.;J Enrique Dominguez-Munoz.;John Windsor.;Wei Huang.;Qing Xia.;Robert Sutton.
来源: Gut. 2020年69卷3期604-605页 1838. Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial.
作者: Grace L H Wong.;Louis H S Lau.;Jessica Y L Ching.;Yee-Kit Tse.;Rachel H Y Ling.;Vincent W S Wong.;Philip W Y Chiu.;James Y W Lau.;Francis K L Chan.
来源: Gut. 2020年69卷4期652-657页
Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding in such patients.
1839. First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene.
作者: Britt-Sabina Petersen.;Bernd Bokemeyer.;Christian Wenker.;Stefan Hoby.;Katrin Baumgartner.;Hermann Will.;Marc P Hoeppner.;Stefan Schreiber.;Ingo Mecklenburg.;Andre Franke.
来源: Gut. 2020年69卷6期1153-1154页 |