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1801. Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system.
作者: Xiafei Hong.;Sitan Qiao.;Fuqiang Li.;Wenze Wang.;Rui Jiang.;Huanwen Wu.;Hao Chen.;Lulu Liu.;Junya Peng.;Jing Wang.;Congwei Jia.;Xiaolong Liang.;Hongmei Dai.;Jialin Jiang.;Taiping Zhang.;Quan Liao.;Menghua Dai.;Lin Cong.;Xianlin Han.;Dan Guo.;Zhiyong Liang.;Dongjing Li.;Zetian Zheng.;Chen Ye.;Siliang Li.;Yupei Zhao.;Kui Wu.;Wenming Wu.
来源: Gut. 2020年69卷5期877-887页
Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-PanNETs) have distinctive clinical presentations but share similar pathological features. Their genetic bases have not been comprehensively compared. Herein, we used whole-genome/whole-exome sequencing (WGS/WES) to identify genetic differences between insulinomas and NF-PanNETs.
1802. Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease.
作者: Melinda Y Hardy.;Amy K Russell.;Catherine Pizzey.;Claerwen M Jones.;Katherine A Watson.;Nicole L La Gruta.;Donald J Cameron.;Jason A Tye-Din.
来源: Gut. 2020年69卷5期830-840页
Barley and rye are major components of the Western diet, and historic feeding studies indicate that they cause clinical effects in patients with coeliac disease (CD). This toxicity has been attributed to sequence homology with immunogenic wheat sequences, but in adults with CD, these cereals stimulate unique T cells, indicating a critical contribution to gluten immunity independent of wheat. Clinical and immune feeding studies with these grains in children with CD are sparse. We undertook a barley and rye feeding study to characterise the clinical and T-cell responses in children with CD.
1803. Faecal haemoglobin concentration among subjects with negative FIT results is associated with the detection rate of neoplasia at subsequent rounds: a prospective study in the context of population based screening programmes in Italy.
作者: Carlo Senore.;Marco Zappa.;Cinzia Campari.;Sergio Crotta.;Paola Armaroli.;Arrigo Arrigoni.;Paola Cassoni.;Rossana Colla.;Mario Fracchia.;Fabrizio Gili.;Grazia Grazzini.;Roberto Lolli.;Patrizia Menozzi.;Lorenzo Orione.;Salvatore Polizzi.;Stefano Rapi.;Emilia Riggi.;Tiziana Rubeca.;Romano Sassatelli.;Carmen Visioli.;Nereo Segnan.
来源: Gut. 2020年69卷3期523-530页
To estimate the predictive role of faecal haemoglobin (f-Hb) concentration among subjects with faecal immunochemical test (FIT) results below the positivity cut-off for the subsequent risk of advanced neoplasia (AN: colorectal cancer-CRC-or advanced adenoma).
1804. Risk of acute arterial events associated with treatment of inflammatory bowel diseases: nationwide French cohort study.
作者: Julien Kirchgesner.;Nynne Nyboe Andersen.;Fabrice Carrat.;Tine Jess.;Laurent Beaugerie.; .
来源: Gut. 2020年69卷5期852-858页
Patients with IBD are at increased risk of acute arterial events. Antitumour necrosis factor (TNF) agents and thiopurines may, via their anti-inflammatory properties, lower the risk of acute arterial events. The aim of this study was to assess the impact of thiopurines and anti-TNFs on the risk of acute arterial events in patients with IBD.
1805. Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.
作者: Yiwei Xiao.;Kuixia Sun.;Zhongping Duan.;Zhixiu Liu.;Yi Li.;Ling Yan.;Yarong Song.;Huaibin Zou.;Hui Zhuang.;Jie Wang.;Jie Li.
来源: Gut. 2020年69卷5期933-941页
This study was performed to explore the correlation between the characteristics of hepatitis B virus (HBV) quasispecies in HBV-infected pregnant women and the risk of immunoprophylaxis failure for their infants.
1806. Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression.
作者: Jialing Shen.;Mengnuo Chen.;Derek Lee.;Cheuk-Ting Law.;Lai Wei.;Felice Ho-Ching Tsang.;Don Wai-Ching Chin.;Carol Lai-Hung Cheng.;Joyce Man-Fong Lee.;Irene Oi-Lin Ng.;Carmen Chak-Lui Wong.;Chun-Ming Wong.
来源: Gut. 2020年69卷2期329-342页
Facilitates Chromatin Transcription (FACT) complex is a histone chaperone participating in DNA repair-related and transcription-related chromatin dynamics. In this study, we investigated its oncogenic functions, underlying mechanisms and therapeutic implications in human hepatocellular carcinoma (HCC).
1809. Intestinal resection rates in Crohn's disease decline across two different epidemiological areas: a consistent observation not merely due to introduction of anti-TNFα.1810. Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis.
作者: Yinglian Xiao.;Shutian Zhang.;Ning Dai.;Guijun Fei.;Khean-Lee Goh.;Hoon Jai Chun.;Bor-Shyang Sheu.;Chui Fung Chong.;Nobuo Funao.;Wen Zhou.;Minhu Chen.
来源: Gut. 2020年69卷2期224-230页
To establish the non-inferior efficacy of vonoprazan versus lansoprazole in the treatment of Asian patients with erosive oesophagitis (EO).
1811. Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.
作者: Yuan Zhuang.;Haifeng C Xu.;Prashant V Shinde.;Jens Warfsmann.;Jelena Vasilevska.;Balamurugan Sundaram.;Kristina Behnke.;Jun Huang.;Jessica I Hoell.;Arndt Borkhardt.;Klaus Pfeffer.;Mohamed S Taha.;Diran Herebian.;Ertan Mayatepek.;Dirk Brenner.;Mohammad Reza Ahmadian.;Verena Keitel.;Dagmar Wieczorek.;Dieter Häussinger.;Aleksandra A Pandyra.;Karl S Lang.;Philipp A Lang.
来源: Gut. 2020年69卷1期133-145页
The Fragile X mental retardation (FMR) syndrome is a frequently inherited intellectual disability caused by decreased or absent expression of the FMR protein (FMRP). Lack of FMRP is associated with neuronal degradation and cognitive dysfunction but its role outside the central nervous system is insufficiently studied. Here, we identify a role of FMRP in liver disease.
1812. Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?
作者: Mayur Garg.;Simon G Royce.;Chris Tikellis.;Claire Shallue.;Duygu Batu.;Elena Velkoska.;Louise M Burrell.;Sheila K Patel.;Lauren Beswick.;Anvesh Jackson.;Kaushali Britto.;Matthew Lukies.;Pavel Sluka.;Hady Wardan.;Yumiko Hirokawa.;Chin Wee Tan.;Maree Faux.;Antony W Burgess.;Patrick Hosking.;Shaun Monagle.;Merlin Thomas.;Peter R Gibson.;John Lubel.
来源: Gut. 2020年69卷5期841-851页
We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis.
1813. Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma.
作者: Li Chen.;Moli Huang.;Jasmine Plummer.;Jian Pan.;Yan Yi Jiang.;Qian Yang.;Tiago Chedraoui Silva.;Nicole Gull.;Stephanie Chen.;Ling Wen Ding.;Omer An.;Henry Yang.;Yulan Cheng.;Jonathan W Said.;Ngan Doan.;Winand Nm Dinjens.;Kevin M Waters.;Richard Tuli.;Simon A Gayther.;Samuel J Klempner.;Benjamin P Berman.;Stephen J Meltzer.;De-Chen Lin.;H Phillip Koeffler.
来源: Gut. 2020年69卷4期630-640页
While oesophageal squamous cell carcinoma remains infrequent in Western populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to eightfold over the past four decades. We aimed to characterise oesophageal cancer-specific and subtypes-specific gene regulation patterns and their upstream transcription factors (TFs). DESIGN: To identify regulatory elements, we profiled fresh-frozen oesophageal normal samples, tumours and cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematical modelling was performed to establish (super)-enhancers landscapes and interconnected transcriptional circuitry formed by master TFs. Coregulation and cooperation between master TFs were investigated by ChIP-Seq, circularised chromosome conformation capture sequencing and luciferase assay. Biological functions of candidate factors were evaluated both in vitro and in vivo.
1814. Novel strategy for oral peptide delivery in incretin-based diabetes treatment.
作者: Yining Xu.;Matthias Van Hul.;Francesco Suriano.;Véronique Préat.;Patrice D Cani.;Ana Beloqui.
来源: Gut. 2020年69卷5期911-919页
To fulfil an unmet therapeutic need for treating type 2 diabetes by developing an innovative oral drug delivery nanosystem increasing the production of glucagon-like peptide-1 (GLP-1) and the absorption of peptides into the circulation.
1817. Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.
作者: Caiwang Yan.;Meng Zhu.;Yanbing Ding.;Ming Yang.;Mengyun Wang.;Gang Li.;Chuanli Ren.;Tongtong Huang.;Wenjun Yang.;Bangshun He.;Meilin Wang.;Fei Yu.;Jinchen Wang.;Ruoxin Zhang.;Tianpei Wang.;Jing Ni.;Jiaping Chen.;Yue Jiang.;Juncheng Dai.;Erbao Zhang.;Hongxia Ma.;Yanong Wang.;Dazhi Xu.;Shukui Wang.;Yun Chen.;Zekuan Xu.;Jianwei Zhou.;Guozhong Ji.;Zhaoming Wang.;Zhengdong Zhang.;Zhibin Hu.;Qingyi Wei.;Hongbing Shen.;Guangfu Jin.
来源: Gut. 2020年69卷4期641-651页
Although a subset of genetic loci have been associated with gastric cancer (GC) risk, the underlying mechanisms are largely unknown. We aimed to identify new susceptibility genes and elucidate their mechanisms in GC development.
1819. Adeno-associated virus in the liver: natural history and consequences in tumour development.
作者: Tiziana La Bella.;Sandrine Imbeaud.;Camille Peneau.;Iadh Mami.;Shalini Datta.;Quentin Bayard.;Stefano Caruso.;Theo Z Hirsch.;Julien Calderaro.;Guillaume Morcrette.;Catherine Guettier.;Valerie Paradis.;Giuliana Amaddeo.;Alexis Laurent.;Laurent Possenti.;Laurence Chiche.;Paulette Bioulac-Sage.;Jean-Frederic Blanc.;Eric Letouze.;Jean-Charles Nault.;Jessica Zucman-Rossi.
来源: Gut. 2020年69卷4期737-747页
Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV infection in the liver and its consequence in tumour development.
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