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161. Physical Activity and Incident Atrial Fibrillation in African Americans: The Jackson Heart Study.
作者: Jack Tiahnybik.;Marielle Siebert.;Daisuke Kamimura.;Wondwosen Yimer.;Yuan-I Min.;Kaustuv Bhattacharya.;James Floyd.;Yi Yang.;Susan R Heckbert.;Michael E Hall.;Adolfo Correa.;Takeki Suzuki.
来源: Circulation. 2025年152卷2期126-128页 162. The Promise and Peril of Learning Algorithms and Predictive Models in Clinical Decision Support: Be Careful What You Train For.
Continued growth in AI-enhanced clinical decision is expected. Representative populations for model training/validation are needed.
163. DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.
作者: Madeleine Carbonneau.;Yi Li.;Yishu Qu.;Yinan Zheng.;Alexis C Wood.;Mengyao Wang.;Chunyu Liu.;Tianxiao Huan.;Roby Joehanes.;Xiuqing Guo.;Jie Yao.;Kent D Taylor.;Russell P Tracy.;Peter Durda.;Yongmei Liu.;W Craig Johnson.;Wendy S Post.;Tom Blackwell.;Jerome I Rotter.;Stephen S Rich.;Susan Redline.;Myriam Fornage.;Jun Wang.;Hongyan Ning.;Lifang Hou.;Donald Lloyd-Jones.;Kendra Ferrier.;Yuan-I Min.;April P Carson.;Laura M Raffield.;Alexander Teumer.;Hans J Grabe.;Henry Völzke.;Matthias Nauck.;Marcus Dörr.;Arce Domingo-Relloso.;Amanda Fretts.;Maria Tellez-Plaza.;Shelley A Cole.;Ana Navas-Acien.;Meng Wang.;Joanne M Murabito.;Nancy L Heard-Costa.;Brenton Prescott.;Vanessa Xanthakis.;Dariush Mozaffarian.;Daniel Levy.;Jiantao Ma.
来源: Circulation. 2025年152卷7期436-449页
The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.
164. Predicting Outcomes in Pediatric Intraluminal Pulmonary Vein Stenosis Using a Comprehensive Standardized Catheterization Assessment: A Prospective Study.
作者: Ryan Callahan.;Kimberlee Gauvreau.;Mirjam Keochakian.;Jesse J Esch.;Diego Porras.;Lisa Bergersen.;Rebecca Beroukhim.;Michael Farias.;David M Harrild.;Christina M Ireland.;Neha Kwatra.;Kathy J Jenkins.
来源: Circ Cardiovasc Interv. 2025年e015002页
Pediatric intraluminal pulmonary vein stenosis (PVS) occurs in a heterogeneous patient population but is unified by its cellular composition in affected pulmonary veins. Enhanced delineation of the hemodynamic and physiological vein consequences of PVS and its impact on vein lumen, vein pressure, wall structure, vein compliance, and wall shear stress has not been studied. The objective is to assess PVS characteristics using multimodal catheterization techniques (angiography, pulmonary vein pressure, intravascular ultrasound, balloon compliance testing, and wall shear stress calculation) and determine their association with vein outcomes.
165. Quantifying Patient Preferences About Features of Nonstatin Lipid-Lowering Therapies: A Discrete Choice Experiment in the United States.
作者: Shelby D Reed.;Jessie Sutphin.;Juan Marcos Gonzalez.;Matthew J Wallace.;Judith J Stephenson.;Batul Electricwala.;Hayden B Bosworth.;Neha Pagidipati.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011804页
Despite the growing number of nonstatin lipid-lowering treatments (NS-LLTs), data are lacking on how patients value their various features and outcomes. Study objectives were to quantify patients' preferences across levels of efficacy, treatment regimens, side effects, and out-of-pocket costs of NS-LLTs and compare approaches with framing treatment efficacy.
166. Predictors of Neurodevelopmental and Mental Health Diagnoses in Congenital Heart Disease: A Danish Population-Based Cohort Study.
作者: Kimberley G Miles.;Dana B Gal.;Dóra Körmendiné Farkas.;Kristina Laugesen.;Henrik Toft Sørensen.;Nadine A Kasparian.;Nicolas L Madsen.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011944页
Over 35% of Danish children with congenital heart disease (CHD) are diagnosed with or treated for a neurodevelopmental or mental health condition. We examined child clinical, parent socioeconomic, and family health factors associated with 4 common diagnostic groups in children with CHD: developmental disorders, intellectual disability, attention-deficit/hyperactivity disorder, and anxiety and mood disorders.
167. Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study.
作者: Rémi Goupil.;Louis-Charles Desbiens.;Amel Merabtine.;Mohsen Agharazii.;François Madore.;Anand Vaidya.;Alexander A Leung.;Gregory A Kline.;Julie L V Shaw.;Tim Ramsay.;Annie-Claire Nadeau-Fredette.;Manish M Sood.;Gregory L Hundemer.
来源: Circulation. 2025年
Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting evidence suggests that milder forms of renin-independent aldosterone production (subclinical PA) are highly prevalent; however, the link between subclinical PA and MACE remains uncertain.
168. The Impact of Fontan Circulatory Failure on Heart Transplant Survival: A 20-Center Retrospective Cohort Study.
作者: Kurt R Schumacher.;David N Rosenthal.;Adriana Batazzi.;Sunkyung Yu.;Garrett Reichle.;Maria Bano.;Shriprasad R Deshpande.;Matthew O'Connor.;Humera Ahmed.;Sharon Chen.;Lydia K Wright.;Steven J Kindel.;Anna Joong.;Michelle Ploutz.;Brian Feingold.;Justin Godown.;Chad Y Mao.;Angela Lorts.;Kathleen E Simpson.;Aecha Ybarra.;Marc E Richmond.;Shahnawaz Amdani.;Jennifer Conway.;Elizabeth D Blume.;Melissa K Cousino.
来源: Circulation. 2025年152卷8期508-518页
Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality rates, including heart failure, multisystem end-organ disease, and need for heart transplant. Specific FCF morbidities have not been rigorously defined, limiting study of how FCF morbidities affect pre-heart transplant and post-heart transplant outcomes. We hypothesized that FCF-related morbidities affect survival from heart transplant waitlisting through 1 year after heart transplant.
170. Z Scores for Pediatric Echocardiography Dimensions Adjusted for Body Size, BMI, and Age.
作者: Jonathan Lauzon-Schnittka.;Virginie Plante.;Nagib Dahdah.;Steven C Greenway.;Christian Drolet.;Kenny Wong.;Andrew S Mackie.;Luc Mertens.;Tiscar Cavallé-Garrido.;Joshua Penslar.;Derek Wong.;Luis Martín Garrido-García.;Frédéric Dallaire.; .
来源: Circ Cardiovasc Imaging. 2025年18卷8期e017944页
Cardiovascular dimensions measured during pediatric echocardiograms must be normalized for body size. However, other variables may confound their interpretation, such as age and abnormal body habitus. This retrospective cross-sectional study of the Canadian Congenital and Pediatric Cardiology Research Network aimed to create Z score equations for commonly measured dimensions in pediatric 2-dimensional echocardiography that were free of residual confounding effects of body size, body mass index, and age.
171. Response by Papathanasiou to Letter Regarding Article, "Disseminated Intracardiac Thrombosis Due to Long-Standing, Asymptomatic Ventricular Fibrillation Under LVAD Support".
作者: Lara S Schlender.;Reza Wakili.;David M Leistner.;Maria Papathanasiou.
来源: Circ Heart Fail. 2025年e013260页 173. Association of Statin Treatment and Dose With the Clinical Course of Small Abdominal Aortic Aneurysms in Men: A 5-Year Prospective Cohort Study From 2 Population-Based Screening Trials.
作者: Joachim S Skovbo.;Lasse M Obel.;Axel C P Diederichsen.;Flemming H Steffensen.;Lars Frost.;Jess Lambrechtsen.;Martin Busk.;Grazina Urbonaviciene.;Kenneth Egstrup.;Marie Dahl.;Marek Karon.;Lars M Rasmussen.;Jesper Hallas.;Jes Sanddal Lindholt.
来源: Circulation. 2025年152卷6期384-396页
Abdominal aortic aneurysms (AAA) present with high morbidity and mortality when they occasionally rupture. No medical therapy has successfully been proven to reduce AAA growth, though both metformin and statins have been identified as potential treatments in multiple meta-analysis. This study aimed to investigate a potential relationship between statin use and AAA growth rates and risk of undergoing repair, rupture, or death.
174. Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction.
作者: Glynnis Garry Bann.;Matthieu Dos Santos.;Kenian Chen.;Wei Tan.;Svetlana Bezprozvannaya.;Peiheng Gan.;Lin Xu.;Ning Liu.;Rhonda Bassel-Duby.;Eric N Olson.
来源: Circulation. 2025年
Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart disease. However, current reprogramming strategies require excessive factors due to epigenetic barriers of adult mouse and human fibroblasts. Recently, we identified the epigenetic factor PHF7 from a screen of gene-regulatory factors as the most potent activator of adult fibroblast-to-cardiomyocyte reprogramming in vitro.
175. Correction to: Evinacumab for Pediatric Patients With Homozygous Familial Hypercholesterolemia.
作者: Albert Wiegman.;Susanne Greber-Platzer.;Shazia Ali.;M Doortje Reijman.;Eliot A Brinton.;Min-Ji Charng.;Shubba Srinivasan.;Carissa Baker-Smith.;Seth Baum.;Julie A Brothers.;Jacob Hartz.;Patrick M Moriarty.;Jeanne Mendell.;Sébastien Bihorel.;Poulabi Banerjee.;Richard T George.;Boaz Hirshberg.;Robert Pordy.
来源: Circulation. 2025年152卷1期e22页 |