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1661. Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements).
作者: Philip Wai Yan Chiu.;Siew C Ng.;Haruhiro Inoue.;D Nageshwar Reddy.;Enqiang Ling Hu.;Joo Young Cho.;Lawrence Ky Ho.;David G Hewett.;Han-Mo Chiu.;Rungsun Rerknimitr.;Hsiu-Po Wang.;Shiaw Hooi Ho.;Dong Wan Seo.;Khean-Lee Goh.;Hisao Tajiri.;Seigo Kitano.;Francis K L Chan.
来源: Gut. 2020年69卷6期991-996页
Coronavirus-19 (COVID-19) caused by SARS-CoV-2 has become a global pandemic. Risk of transmission may occur during endoscopy and the goal is to prevent infection among healthcare professionals while providing essential services to patients. Asia was the first continent to have a COVID-19 outbreak, and this position statement of the Asian Pacific Society for Digestive Endoscopy shares our successful experience in maintaining safe and high-quality endoscopy practice at a time when resources are limited. Sixteen experts from key societies of digestive endoscopy in Asia were invited to develop position statements, including patient triage and risk assessment before endoscopy, resource prioritisation and allocation, regular monitoring of personal protective equipment, infection control measures, protective device training and implementation of a strategy for stepwise resumption of endoscopy services after control of the COVID-19 outbreak.
1662. Transition to quantitative faecal immunochemical testing from guaiac faecal occult blood testing in a fully rolled-out population-based national bowel screening programme.
作者: Gavin Clark.;Judith A Strachan.;Frank A Carey.;Thomas Godfrey.;Audrey Irvine.;Alisson McPherson.;Jess Brand.;Annie S Anderson.;Callum G Fraser.;Robert Jc Steele.
来源: Gut. 2021年70卷1期106-113页
Faecal immunochemical tests (FIT) are replacing guaiac faecal occult blood tests (FOBT) in colorectal cancer (CRC) screening. Data from the first year of FIT screening were compared with those from FOBT screening and assumptions based on a pilot evaluation of FIT.
1664. HBV vaccination and HBV infection induces HBV-specific natural killer cell memory.
作者: Ratna S Wijaya.;Scott A Read.;Naomi R Truong.;Shuanglin Han.;Dishen Chen.;Haleh Shahidipour.;Nicole L Fewings.;Stephen Schibeci.;Mahmoud K Azardaryany.;Grant P Parnell.;David Booth.;David van der Poorten.;Rita Lin.;Jacob George.;Mark W Douglas.;Golo Ahlenstiel.
来源: Gut. 2021年70卷2期357-369页
Vaccination against hepatitis B virus (HBV) confers protection from subsequent infection through immunological memory that is traditionally considered the domain of the adaptive immune system. This view has been challenged following the identification of antigen-specific memory natural killer cells (mNKs) in mice and non-human primates. While the presence of mNKs has been suggested in humans based on the expansion of NK cells following pathogen exposure, evidence regarding antigen-specificity is lacking. Here, we demonstrate the existence of HBV-specific mNKs in humans after vaccination and in chronic HBV infection.
1666. No difference in hepatocellular carcinoma risk between chronic hepatitis B patients treated with entecavir versus tenofovir.
Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are first-line agents for the treatment of chronic hepatitis B (CHB). Recent studies have challenged the assumption that these agents are equally effective at preventing hepatocellular carcinoma (HCC). We aimed to determine whether the risk of HCC and mortality differ in patients with CHB treated with ETV and TDF.
1669. Mortality in biopsy-proven alcohol-related liver disease: a population-based nationwide cohort study of 3453 patients.
作者: Hannes Hagström.;Maja Thiele.;Bjorn Roelstraete.;Jonas Söderling.;Jonas F Ludvigsson.
来源: Gut. 2021年70卷1期170-179页
Patients with alcohol-related liver disease (ALD) are at increased risk of death, but studies have rarely investigated the significance of histological severity or estimated relative risks compared with a general population. We examined mortality in a nationwide cohort of biopsy-proven ALD.
1670. Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study.
作者: Sharon J Hutchinson.;Heather Valerio.;Scott A McDonald.;Alan Yeung.;Kevin Pollock.;Shanley Smith.;Stephen Barclay.;John F Dillon.;Raymond Fox.;Peter Bramley.;Andrew Fraser.;Nicholas Kennedy.;Rory N Gunson.;Kate Templeton.;Hamish Innes.;Allan McLeod.;Amanda Weir.;Peter C Hayes.;David Goldberg.
来源: Gut. 2020年69卷12期2223-2231页
Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland.
1671. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.
作者: Frank Jühling.;Nourdine Hamdane.;Emilie Crouchet.;Shen Li.;Houssein El Saghire.;Atish Mukherji.;Naoto Fujiwara.;Marine A Oudot.;Christine Thumann.;Antonio Saviano.;Armando Andres Roca Suarez.;Kaku Goto.;Ricard Masia.;Mozhdeh Sojoodi.;Gunisha Arora.;Hiroshi Aikata.;Atsushi Ono.;Parissa Tabrizian.;Myron Schwartz.;Stephen J Polyak.;Irwin Davidson.;Christian Schmidl.;Christoph Bock.;Catherine Schuster.;Kazuaki Chayama.;Patrick Pessaux.;Kenneth K Tanabe.;Yujin Hoshida.;Mirjam B Zeisel.;François Ht Duong.;Bryan C Fuchs.;Thomas F Baumert.
来源: Gut. 2021年70卷1期157-169页
Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory and chemopreventive approaches are absent. Chronic hepatitis C (CHC) results in epigenetic alterations driving HCC risk and persisting following cure. Here, we aimed to investigate epigenetic modifications as targets for liver cancer chemoprevention.
1672. Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.
作者: Helen H N Yan.;Hoi Cheong Siu.;Siu Lun Ho.;Sarah S K Yue.;Yang Gao.;Wai Yin Tsui.;Dessy Chan.;April S Chan.;Jason W H Wong.;Alice H Y Man.;Bernard C H Lee.;Annie S Y Chan.;Anthony K W Chan.;Ho Sang Hui.;Arthur K L Cheung.;Wai Lun Law.;Oswens S H Lo.;Siu Tsan Yuen.;Hans Clevers.;Suet Yi Leung.
来源: Gut. 2020年69卷12期2165-2179页
Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.
1673. Transmucosal diverticular myotomy for the treatment of oesophageal diverticula associated with spastic motility disorders.
Thoracic oesophageal diverticula are often associated with spastic motility disorders. Despite correction of the underlying motility disorder, in a subgroup of patients, symptoms persist, primarily regurgitation. Surgical diverticulectomy is then proposed; however, as the approach is thoracoscopic or via thoracotomy, it is associated with significant morbidity and cost. Descriptions of endoscopic techniques for the treatment of symptomatic midoesophageal diverticula are few. We propose the novel technique of diverticular myotomy (DM) to treat this disorder. In this case series, we describe two patients who successfully underwent DM with no adverse outcomes and excellent clinical results at 24-month follow-up.
1674. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms.
作者: Xi Jin.;Jiang-Shan Lian.;Jian-Hua Hu.;Jianguo Gao.;Lin Zheng.;Yi-Min Zhang.;Shao-Rui Hao.;Hong-Yu Jia.;Huan Cai.;Xiao-Li Zhang.;Guo-Dong Yu.;Kai-Jin Xu.;Xiao-Yan Wang.;Jue-Qing Gu.;Shan-Yan Zhang.;Chan-Yuan Ye.;Ci-Liang Jin.;Ying-Feng Lu.;Xia Yu.;Xiao-Peng Yu.;Jian-Rong Huang.;Kang-Li Xu.;Qin Ni.;Cheng-Bo Yu.;Biao Zhu.;Yong-Tao Li.;Jun Liu.;Hong Zhao.;Xuan Zhang.;Liang Yu.;Yong-Zheng Guo.;Jun-Wei Su.;Jing-Jing Tao.;Guan-Jing Lang.;Xiao-Xin Wu.;Wen-Rui Wu.;Ting-Ting Qv.;Dai-Rong Xiang.;Ping Yi.;Ding Shi.;Yanfei Chen.;Yue Ren.;Yun-Qing Qiu.;Lan-Juan Li.;Jifang Sheng.;Yida Yang.
来源: Gut. 2020年69卷6期1002-1009页
The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics.
1676. Discontinuation of nucleos(t)ide analogues is not associated with a higher risk of HBsAg seroreversion after antiviral-induced HBsAg seroclearance: a nationwide multicentre study.
作者: Minseok Albert Kim.;Seung Up Kim.;Dong Hyun Sinn.;Jeong Won Jang.;Young-Suk Lim.;Sang Hoon Ahn.;Jae-Jun Shim.;Yeon Seok Seo.;Yang Hyun Baek.;Sang Gyune Kim.;Young Seok Kim.;Ji Hoon Kim.;Won Hyeok Choe.;Hyung Joon Yim.;Hyun Woong Lee.;Jung Hyun Kwon.;Sung Won Lee.;Jae Young Jang.;Hwi Young Kim.;Yewan Park.;Gi-Ae Kim.;Hyun Yang.;Han Ah Lee.;Myeongseok Koh.;Young-Sun Lee.;Minkoo Kim.;Young Chang.;Yoon Jun Kim.;Jung-Hwan Yoon.;Fabien Zoulim.;Jeong-Hoon Lee.
来源: Gut. 2020年69卷12期2214-2222页
Direct comparison of the clinical outcomes between nucleos(t)ide analogue (NA) discontinuation versus NA continuation has not been performed in patients with chronic hepatitis B who achieved HBsAg-seroclearance. Whether NA discontinuation was as safe as NA continuation after NA-induced surface antigen of HBV (HBsAg) seroclearance was investigated in the present study.
1677. Adenoma detection by Endocuff-assisted versus standard colonoscopy in routine practice: a cluster-randomised crossover trial.
作者: David Karsenti.;Gaelle Tharsis.;Bastien Perrot.;Philippe Cattan.;Gilles Tordjman.;Franck Venezia.;Elie Zrihen.;Dominique Gillot.;Agnes Gillet.;Charles Hagege.;Joelle Samama.;Isabelle Etienney.;Jean-Philippe Lab.;Bernard Guigui.;Jacqueline Zago.;Bouchra Benkessou.;Pascal Burtin.;Maryan Cavicchi.
来源: Gut. 2020年69卷12期2159-2164页
Endocuff Vision (ECV) is the second generation of a device designed to improve polyp detection. The aim of this study was to evaluate its impact on adenoma detection rate (ADR) in routine colonoscopy.
1679. Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis.
Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality. We updated this meta-analysis, as more data has accumulated. We also evaluated impact of eradication therapy on future risk of gastric cancer in patients having endoscopic mucosal resection for gastric neoplasia.
1680. Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease.
作者: Justine Vily-Petit.;Maud Soty-Roca.;Marine Silva.;Margaux Raffin.;Amandine Gautier-Stein.;Fabienne Rajas.;Gilles Mithieux.
来源: Gut. 2020年69卷12期2193-2202页
Hepatic steatosis accompanying obesity is a major health concern, since it may initiate non-alcoholic fatty liver disease (NAFLD) and associated complications like cirrhosis or cancer. Intestinal gluconeogenesis (IGN) is a recently described function that contributes to the metabolic benefits of specific macronutrients as protein or soluble fibre, via the initiation of a gut-brain nervous signal triggering brain-dependent regulations of peripheral metabolism. Here, we investigate the effects of IGN on liver metabolism, independently of its induction by the aforementioned macronutrients.
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