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1641. Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects.
作者: M Gordian Adam.;Georg Beyer.;Nicole Christiansen.;Beate Kamlage.;Christian Pilarsky.;Marius Distler.;Tim Fahlbusch.;Ansgar Chromik.;Fritz Klein.;Marcus Bahra.;Waldemar Uhl.;Robert Grützmann.;Ujjwal M Mahajan.;Frank U Weiss.;Julia Mayerle.;Markus M Lerch.
来源: Gut. 2021年70卷11期2150-2158页
Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to organ dysfunction, chronic pain, an increased risk for pancreatic cancer and considerable morbidity. Due to a lack of specific biomarkers, diagnosis is based on symptoms and specific but insensitive imaging features, preventing an early diagnosis and appropriate management.
1642. COVID-19 and endoscopic services: the impact of delays in therapeutic colonoscopies on patients.
作者: Syazeddy Samani.;Nasir Mir.;David N Naumann.;Michael Ding.;Sharad Karandikar.;Jason Goh.;Marietta Iacucci.;Marcus Mottershead.;Vanja Giljaca.
来源: Gut. 2021年70卷10期2019-2020页 1643. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
作者: Ane Olazagoitia-Garmendia.;Linda Zhang.;Paula Mera.;Julie K Godbout.;Maialen Sebastian-DelaCruz.;Iraia Garcia-Santisteban.;Luis Manuel Mendoza.;Alain Huerta.;Iñaki Irastorza.;Govind Bhagat.;Peter H Green.;Laura Herrero.;Dolors Serra.;Jose Antonio Rodriguez.;Elena F Verdu.;Chuan He.;Jose Ramon Bilbao.;Ainara Castellanos-Rubio.
来源: Gut. 2022年71卷1期68-76页
Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten free diet. Human leucocyte antigen (HLA) genes and several non-HLA regions have been associated with the genetic susceptibility to CD, but their role in the pathogenesis of the disease is still essentially unknown, making it complicated to develop much needed non-dietary treatments. Here, we describe the functional involvement of a CD-associated single-nucleotide polymorphism (SNP) located in the 5'UTR of XPO1 in the inflammatory environment characteristic of the coeliac intestinal epithelium.
1646. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways.
作者: María Arnoriaga-Rodríguez.;Jordi Mayneris-Perxachs.;Oren Contreras-Rodríguez.;Aurelijus Burokas.;Juan-Antonio Ortega-Sanchez.;Gerard Blasco.;Claudia Coll.;Carles Biarnés.;Anna Castells-Nobau.;Josep Puig.;Josep Garre-Olmo.;Rafel Ramos.;Salvador Pedraza.;Ramon Brugada.;Joan C Vilanova.;Joaquín Serena.;Jordi Barretina.;Jordi Gich.;Vicente Pérez-Brocal.;Andrés Moya.;Xavier Fernández-Real.;Lluis Ramio-Torrentà.;Reinald Pamplona.;Joaquim Sol.;Mariona Jové.;Wifredo Ricart.;Manuel Portero-Otin.;Rafael Maldonado.;Jose Manuel Fernández-Real.
来源: Gut. 2021年70卷12期2283-2296页
Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits.
1647. Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study.
作者: Sabine Weber.;Johannes C Hellmuth.;Clemens Scherer.;Maximilian Muenchhoff.;Julia Mayerle.;Alexander L Gerbes.
来源: Gut. 2021年70卷10期1925-1932页
Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to SARS-CoV-2 infection remains unclear with a need for prospective studies on the impact of liver function test (LFT) abnormalities at baseline.
1648. Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.
作者: Lena Allweiss.;Katja Giersch.;Andrea Pirosu.;Tassilo Volz.;Robert C Muench.;Rudolf K Beran.;Stephan Urban.;Hassan Javanbakht.;Simon P Fletcher.;Marc Lütgehetmann.;Maura Dandri.
来源: Gut. 2022年71卷2期372-381页
Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-IFNα) on the viral regulatory HBx protein and the structural maintenance of chromosome 5/6 complex (SMC5/6), a host factor suppressing cccDNA transcription. In particular, we assessed whether interventions lowering HBV transcripts can achieve and maintain silencing of cccDNA transcription in vivo.
1649. Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut-testis axis.
作者: Teng Zhang.;Peng Sun.;Qi Geng.;Haitao Fan.;Yutian Gong.;Yanting Hu.;Liying Shan.;Yuanchao Sun.;Wei Shen.;Yang Zhou.
来源: Gut. 2022年71卷1期78-87页
Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We aim to uncover the direct evidence involving the gut-testis axis in the aetiology of impaired spermatogenesis.
1651. Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers.
作者: Han-Mo Chiu.;Grace Hsiao-Hsuan Jen.;Ying-Wei Wang.;Jean Ching-Yuan Fann.;Chen-Yang Hsu.;Ya-Chung Jeng.;Amy Ming-Fang Yen.;Sherry Yueh-Hsia Chiu.;Sam Li-Sheng Chen.;Wen-Feng Hsu.;Yi-Chia Lee.;Ming-Shiang Wu.;Chien-Yuan Wu.;Yann-Yuh Jou.;Tony Hsiu-Hsi Chen.
来源: Gut. 2021年70卷12期2321-2329页
To measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening.
1652. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
作者: Shumei Song.;Qiongrong Chen.;Yuan Li.;Guang Lei.;Ailing Scott.;Longfei Huo.;Cordelia Y Li.;Jeannelyn Santiano Estrella.;Arlene Correa.;Melissa Pool Pizzi.;Lang Ma.;Jiankang Jin.;Bin Liu.;Ying Wang.;Lianchun Xiao.;Wayne L Hofstetter.;Jeffrey H Lee.;Brian Weston.;Manoop Bhutani.;Namita Shanbhag.;Randy L Johnson.;Boyi Gan.;Shaozhong Wei.;Jaffer A Ajani.
来源: Gut. 2021年70卷12期2238-2248页
Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy resistance. We sought to elucidate the antitumour action of a BCL-2 inhibitor, AT101 in GEC in vitro, in vivo and in a clinical trial.
1653. Transcolonic endoscopic appendectomy: a novel natural orifice transluminal endoscopic surgery (NOTES) technique for the sessile serrated lesions involving the appendiceal orifice.
作者: Tao Chen.;Aiping Xu.;Jingjing Lian.;Yuan Chu.;Haibin Zhang.;Meidong Xu.
来源: Gut. 2021年70卷10期1812-1814页 1654. Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.
作者: Jonel Trebicka.;Wenyi Gu.;Victor de Ledinghen.;Christophe Aubé.;Aleksander Krag.;Michael Praktiknjo.;Laurent Castera.;Jerome Dumortier.;David Josef Maria Bauer.;Mireen Friedrich-Rust.;Stanislas Pol.;Ivica Grgurevic.;Rongqin Zheng.;Sven Francque.;Halima Gottfriedovà.;Sanda Mustapic.;Ioan Sporea.;Annalisa Berzigotti.;Frank Erhard Uschner.;Benedikt Simbrunner.;Maxime Ronot.;Christophe Cassinotto.;Maria Kjaergaard.;Filipe Andrade.;Martin Schulz.;Georg Semmler.;Ida Tjesic Drinkovic.;Johannes Chang.;Maximilian Joseph Brol.;Pierre Emmanuel Rautou.;Thomas Vanwolleghem.;Christian P Strassburg.;Jerome Boursier.;Philip Georg Ferstl.;Ditlev Nytoft Rasmussen.;Thomas Reiberger.;Valerie Vilgrain.;Aymeric Guibal.;Olivier Guillaud.;Stefan Zeuzem.;Camille Vassord.;Xue Lu.;Luisa Vonghia.;Renata Senkerikova.;Alina Popescu.;Cristina Margini.;Wenping Wang.;Maja Thiele.;Chrisitan Jansen.
来源: Gut. 2022年71卷2期402-414页
Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients.
1655. Artificial intelligence in GI endoscopy: stumbling blocks, gold standards and the role of endoscopy societies.
作者: Rüdiger Schmitz.;Rene Werner.;Alessandro Repici.;Raf Bisschops.;Alexander Meining.;Michael Zornow.;Helmut Messmann.;Cesare Hassan.;Prateek Sharma.;Thomas Rösch.
来源: Gut. 2022年71卷3期451-454页 1656. SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting.
作者: Corey A Siegel.;Gil Y Melmed.;Dermot Pb McGovern.;Victoria Rai.;Florian Krammer.;David T Rubin.;Maria T Abreu.;Marla C Dubinsky.; .; .
来源: Gut. 2021年70卷4期635-640页 1657. Impaired antibacterial response of liver sinusoidal Vγ9+Vδ2+ T cells in patients with chronic liver disease.
作者: Min-Seok Rha.;Ji Won Han.;June-Young Koh.;Ha Seok Lee.;Jong Hoon Kim.;Kyungjoo Cho.;Soon Il Kim.;Myoung Soo Kim.;Jae Geun Lee.;Su-Hyung Park.;Dong Jin Joo.;Jun Yong Park.;Eui-Cheol Shin.
来源: Gut. 2022年71卷3期605-615页
The liver acts as a frontline barrier against diverse gut-derived pathogens, and the sinusoid is the primary site of liver immune surveillance. However, little is known about liver sinusoidal immune cells in the context of chronic liver disease (CLD). Here, we investigated the antibacterial capacity of liver sinusoidal γδ T cells in patients with various CLDs.
1658. Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
作者: Benjamin Goeppert.;Damian Stichel.;Reka Toth.;Sarah Fritzsche.;Moritz Anton Loeffler.;Anna Melissa Schlitter.;Olaf Neumann.;Yassen Assenov.;Monika Nadja Vogel.;Arianeb Mehrabi.;Katrin Hoffmann.;Bruno Köhler.;Christoph Springfeld.;Dieter Weichenhan.;Christoph Plass.;Irene Esposito.;Peter Schirmacher.;Andreas von Deimling.;Stephanie Roessler.
来源: Gut. 2022年71卷2期391-401页
A detailed understanding of the molecular alterations in different forms of cholangiocarcinogenesis is crucial for a better understanding of cholangiocarcinoma (CCA) and may pave the way to early diagnosis and better treatment options.
1659. Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn's disease.
作者: Ren Mao.;Genevieve Doyon.;Ilyssa O Gordon.;Jiannan Li.;Sinan Lin.;Jie Wang.;Thi Hong Nga Le.;Michael Elias.;Satya Kurada.;Brian Southern.;Mitchell Olman.;Minhu Chen.;Shuai Zhao.;Dina Dejanovic.;Jyotsna Chandra.;Pranab K Mukherjee.;Gail West.;David R Van Wagoner.;Claudio Fiocchi.;Florian Rieder.
来源: Gut. 2022年71卷1期55-67页
Creeping fat, the wrapping of mesenteric fat around the bowel wall, is a typical feature of Crohn's disease, and is associated with stricture formation and bowel obstruction. How creeping fat forms is unknown, and we interrogated potential mechanisms using novel intestinal tissue and cell interaction systems.
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