当前位置: 首页 >> 检索结果
1562. Long-term safety of infants from mothers with chronic hepatitis B treated with tenofovir disoproxil in China.
作者: Calvin Q Pan.;Erhei Dai.;Zhongping Duan.;Guorong Han.;Wenjing Zhao.;Yuming Wang.;Huaihong Zhang.;Baoshen Zhu.;Hongxiu Jiang.;Shuqin Zhang.;Xiaohu Zhang.;Huaibin Zou.;Xiuli Chen.;Yu Chen.
来源: Gut. 2022年71卷4期798-806页
The physical and neuromental development of infants remains uncertain after fetal exposure to tenofovir disoproxil fumarate (TDF) for the prevention of mother-to-child transmission of HBV. We aimed to investigate the safety of TDF therapy during the third trimester of pregnancy.
1563. Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-rationale for targeting ARID1A deficiency.
作者: Xiaochuan Dong.;Shumei Song.;Yuan Li.;Yibo Fan.;Lulu Wang.;Ruiping Wang.;Longfei Huo.;Ailing Scott.;Yan Xu.;Melissa Pool Pizzi.;Lang Ma.;Ying Wang.;Jiangkang Jin.;Wei Zhao.;Xiaodan Yao.;Randy L Johnson.;Linghua Wang.;Zhenning Wang.;Guang Peng.;Jaffer A Ajani.
来源: Gut. 2022年71卷3期467-478页
Gastric adenocarcinoma (GAC) is a lethal disease with limited therapeutic options. Genetic alterations in chromatin remodelling gene AT-rich interactive domain 1A (ARID1A) and mTOR pathway activation occur frequently in GAC. Targeting the mechanistic target of rapamycin (mTOR) pathway in unselected patients has failed to show survival benefit. A deeper understanding of GAC might identify a subset that can benefit from mTOR inhibition.
1565. Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial.
作者: Siew C Ng.;Zhilu Xu.;Joyce Wing Yan Mak.;Keli Yang.;Qin Liu.;Tao Zuo.;Whitney Tang.;Louis Lau.;Rashid N Lui.;Sunny H Wong.;Yee Kit Tse.;Amy Y L Li.;Kitty Cheung.;Jessica Y L Ching.;Vincent W S Wong.;Alice P S Kong.;Ronald C W Ma.;Elaine Y K Chow.;Simon K H Wong.;Ivan Chak Hang Ho.;Paul K S Chan.;Francis K L Chan.
来源: Gut. 2022年71卷4期716-723页
The impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM).
1567. Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.
作者: Nestor Nivardo Jiménez-Vargas.;Yang Yu.;Dane D Jensen.;Diana Daeun Bok.;Matthew Wisdom.;Rocco Latorre.;Cintya Lopez.;Josue O Jaramillo-Polanco.;Claudius Degro.;Mabel Guzman-Rodriguez.;Quentin Tsang.;Zachary Snow.;Brian L Schmidt.;David E Reed.;Alan Edward Lomax.;Kara Gross Margolis.;Christoph Stein.;Nigel W Bunnett.;Stephen J Vanner.
来源: Gut. 2022年71卷4期695-704页
The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), which preferentially activates MOPr in acidified diseased tissues, would inhibit pain in a preclinical model of inflammatory bowel disease (IBD) without side effects in healthy tissues.
1572. Radiology-guided percutaneous approach is superior to EUS for performing liver biopsies.
作者: Ji Young Bang.;Thomas J Ward.;Shady Guirguis.;Konrad Krall.;Francisco Contreras.;Nirag Jhala.;Udayakumar Navaneethan.;Robert H Hawes.;Shyam Varadarajulu.
来源: Gut. 2021年70卷12期2224-2226页 1573. Predicting endoscopic remission in Crohn's disease by the modified multiplier SES-CD (MM-SES-CD).
作者: Neeraj Narula.;Emily C L Wong.;Jean-Frederic Colombel.;William J Sandborn.;John Kenneth Marshall.;Marco Daperno.;Walter Reinisch.;Parambir S Dulai.
来源: Gut. 2022年71卷6期1078-1087页
The Simple Endoscopic Score for Crohn's disease (SES-CD) is the primary tool for measurement of mucosal inflammation in clinical trials but lacks prognostic potential. We set to develop and validate a modified multiplier of the SES-CD (MM-SES-CD), which takes into consideration each individual parameter's prognostic value for achieving endoscopic remission (ER) while on active therapy.
1575. Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment.
作者: Ester Pagano.;Joshua E Elias.;Georg Schneditz.;Svetlana Saveljeva.;Lorraine M Holland.;Francesca Borrelli.;Tom H Karlsen.;Arthur Kaser.;Nicole C Kaneider.
来源: Gut. 2022年71卷3期509-520页
Primary sclerosing cholangitis (PSC) is in 70% of cases associated with inflammatory bowel disease. The hypermorphic T108M variant of the orphan G protein-coupled receptor GPR35 increases risk for PSC and ulcerative colitis (UC), conditions strongly predisposing for inflammation-associated liver and colon cancer. Lack of GPR35 reduces tumour numbers in mouse models of spontaneous and colitis associated cancer. The tumour microenvironment substantially determines tumour growth, and tumour-associated macrophages are crucial for neovascularisation. We aim to understand the role of the GPR35 pathway in the tumour microenvironment of spontaneous and colitis-associated colon cancers.
1577. Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab.
作者: Nicholas A Kennedy.;James R Goodhand.;Claire Bewshea.;Rachel Nice.;Desmond Chee.;Simeng Lin.;Neil Chanchlani.;Jeffrey Butterworth.;Rachel Cooney.;Nicholas M Croft.;Ailsa L Hart.;Peter M Irving.;Klaartje B Kok.;Christopher A Lamb.;Jimmy K Limdi.;Jonathan Macdonald.;Dermot Pb McGovern.;Shameer J Mehta.;Charles D Murray.;Kamal V Patel.;Richard Cg Pollok.;Timothy Raine.;Richard K Russell.;Christian P Selinger.;Philip J Smith.;Jack Bowden.;Timothy J McDonald.;Charlie W Lees.;Shaji Sebastian.;Nicholas Powell.;Tariq Ahmad.; .
来源: Gut. 2021年70卷5期865-875页
Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious respiratory infections. We sought to determine whether infliximab-treated patients with IBD have attenuated serological responses to SARS-CoV-2 infections.
1580. Composition, diversity and potential utility of intervention-naïve pancreatic cancer intratumoral microbiome signature profiling via endoscopic ultrasound.
作者: Ferga C Gleeson.;Patricio Jeraldo.;Michael J Levy.;Stephen J Murphy.;Helena Mendes-Soares.;Giannoula Karagouga.;Alexa F Mccune.;Ana Garcia Garcia Deparedes.;Benjamin R Kipp.;Stephanie D Song.;Sahil Khanna.;Darrell S Pardi.;Nicholas Chia.
来源: Gut. 2022年71卷2期441-443页 |