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1521. Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium.
作者: Ozge Kayisoglu.;Franziska Weiss.;Carolin Niklas.;Isabella Pierotti.;Malvika Pompaiah.;Nina Wallaschek.;Christoph-Thomas Germer.;Armin Wiegering.;Sina Bartfeld.
来源: Gut. 2021年70卷4期687-697页
The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear.
1523. International trends in oesophageal cancer survival by histological subtype between 1995 and 2014.
作者: Eileen Morgan.;Isabelle Soerjomataram.;Anna T Gavin.;Mark J Rutherford.;Piers Gatenby.;Aude Bardot.;Jacques Ferlay.;Oliver Bucher.;Prithwish De.;Gerda Engholm.;Christopher Jackson.;Serena Kozie.;Alana Little.;Bjorn Møller.;Lorraine Shack.;Hanna Tervonen.;Vicky Thursfield.;Sally Vernon.;Paul M Walsh.;Ryan R Woods.;Christian Finley.;Neil Merrett.;Dianne L O'Connell.;John V Reynolds.;Freddie Bray.;Melina Arnold.
来源: Gut. 2021年70卷2期234-242页
Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).
1524. Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1.
作者: Arnaud Köhler.;Sandrine Delbauve.;Justine Smout.;David Torres.;Véronique Flamand.
来源: Gut. 2021年70卷3期511-521页
Induction of immune protection against pathogens is particularly crucial during the neonatal period dominated by anti-inflammatory and tolerance immunity. The preclinical study was carried out to determine whether environmental factors such as microbiota may influence early life immunity by impacting the development and the functional maturation of precursors of type 1 conventional dendritic cells (pre-cDC1), endowed with regulatory properties.
1526. Ranking microbiome variance in inflammatory bowel disease: a large longitudinal intercontinental study.
作者: Adam G Clooney.;Julia Eckenberger.;Emilio Laserna-Mendieta.;Kathryn A Sexton.;Matthew T Bernstein.;Kathy Vagianos.;Michael Sargent.;Feargal J Ryan.;Carthage Moran.;Donal Sheehan.;Roy D Sleator.;Laura E Targownik.;Charles N Bernstein.;Fergus Shanahan.;Marcus J Claesson.
来源: Gut. 2021年70卷3期499-510页
The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional variability of the gut microbiota is unclear.
1527. Transoesophageal endoscopic removal of a benign mediastinal tumour: a new field for endotherapy?
作者: Pingting Gao.;Quanlin Li.;Jianwei Hu.;Jiaxin Xu.;Shengli Lin.;Mingyan Cai.;Lili Ma.;Weifeng Chen.;Yiqun Zhang.;Shi-Yao Chen.;Yunshi Zhong.;Liqing Yao.;Pinghong Zhou.
来源: Gut. 2020年69卷10期1727-1729页 1529. Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
作者: Min Zhang.;Shuofeng Hu.;Min Min.;Yanli Ni.;Zheng Lu.;Xiaotian Sun.;Jiaqi Wu.;Bing Liu.;Xiaomin Ying.;Yan Liu.
来源: Gut. 2021年70卷3期464-475页
Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq).
1531. Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: a RAND appropriateness panel.
作者: Shahida Din.;Alexandra Kent.;Richard C Pollok.;Susanna Meade.;Nicholas A Kennedy.;Ian Arnott.;R Mark Beattie.;Felix Chua.;Rachel Cooney.;Robin J Dart.;James Galloway.;Daniel R Gaya.;Subrata Ghosh.;Mark Griffiths.;Laura Hancock.;Richard Hansen.;Ailsa Hart.;Christopher Andrew Lamb.;Charlie W Lees.;Jimmy K Limdi.;James O Lindsay.;Kamal Patel.;Nick Powell.;Charles D Murray.;Chris Probert.;Tim Raine.;Christian Selinger.;Shaji Sebastian.;Philip J Smith.;Phil Tozer.;Andrew Ustianowski.;Lisa Younge.;Mark A Samaan.;Peter M Irving.
来源: Gut. 2020年69卷10期1769-1777页
Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines as a reference point.
1533. SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.
作者: Lea Južnić.;Kenneth Peuker.;Anne Strigli.;Mario Brosch.;Alexander Herrmann.;Robert Häsler.;Michael Koch.;Liz Matthiesen.;Yvonne Zeissig.;Britt-Sabina Löscher.;Alexander Nuber.;Gunnar Schotta.;Volker Neumeister.;Triantafyllos Chavakis.;Thomas Kurth.;Mathias Lesche.;Andreas Dahl.;Anne von Mässenhausen.;Andreas Linkermann.;Stefan Schreiber.;Konrad Aden.;Philip C Rosenstiel.;Andre Franke.;Jochen Hampe.;Sebastian Zeissig.
来源: Gut. 2021年70卷3期485-498页
The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the role of SET Domain Bifurcated Histone Lysine Methyltransferase 1, also known as ESET (SETDB1), a histone H3K9 methyltransferase, in intestinal epithelial homeostasis and IBD.
1534. Neither black nor white: do altered intestinal microbiota reflect chronic liver disease severity?
作者: Felix Goeser.;Philipp Münch.;Till Robin Lesker.;Philipp Ludwig Lutz.;Benjamin Krämer.;Dominik J Kaczmarek.;Claudia Finnemann.;Hans Dieter Nischalke.;Robert Geffers.;Marijo Parcina.;Alice McHardy.;Christian Strassburg.;Achim Hoerauf.;Jacob Nattermann.;Isabelle Bekeredjian-Ding.;Ulrich Spengler.
来源: Gut. 2021年70卷2期438-440页 1535. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.
作者: Waku Hatta.;Yosuke Tsuji.;Toshiyuki Yoshio.;Naomi Kakushima.;Shu Hoteya.;Hisashi Doyama.;Yasuaki Nagami.;Takuto Hikichi.;Masakuni Kobayashi.;Yoshinori Morita.;Tetsuya Sumiyoshi.;Mikitaka Iguchi.;Hideomi Tomida.;Takuya Inoue.;Tomoyuki Koike.;Tatsuya Mikami.;Kenkei Hasatani.;Jun Nishikawa.;Tomoaki Matsumura.;Hiroko Nebiki.;Dai Nakamatsu.;Ken Ohnita.;Haruhisa Suzuki.;Hiroya Ueyama.;Yoshito Hayashi.;Mitsushige Sugimoto.;Shinjiro Yamaguchi.;Tomoki Michida.;Tomoyuki Yada.;Yoshiro Asahina.;Toshiaki Narasaka.;Shiko Kuribasyashi.;Shu Kiyotoki.;Katsuhiro Mabe.;Tomohiro Nakamura.;Naoki Nakaya.;Mitsuhiro Fujishiro.;Atsushi Masamune.
来源: Gut. 2021年70卷3期476-484页
Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC.
1536. One world, one pandemic, many guidelines: management of liver diseases during COVID-19.
作者: Steven Bollipo.;Devika Kapuria.;Atoosa Rabiee.;Gil Ben-Yakov.;Rashid N Lui.;Hye Won Lee.;Goutham Kumar.;Keith Siau.;Juan Turnes.;Renumathy Dhanasekaran.
来源: Gut. 2020年69卷8期1369-1372页 1537. Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series.
作者: Tobias Janowitz.;Eva Gablenz.;David Pattinson.;Timothy C Wang.;Joseph Conigliaro.;Kevin Tracey.;David Tuveson.
来源: Gut. 2020年69卷9期1592-1597页
Treatment options for non-hospitalised patients with coronavirus disease 2019 (COVID-19) to reduce morbidity, mortality and spread of the disease are an urgent global need. The over-the-counter histamine-2 receptor antagonist famotidine is a putative therapy for COVID-19. We quantitively assessed longitudinal changes in patient reported outcome measures in non-hospitalised patients with COVID-19 who self-administered high-dose famotidine orally.
1538. Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom.
作者: Yizhou Ye.;Baoguo Jiang.;Sudhakar Manne.;Peter L Moses.;Cristina Almansa.;Dimitri Bennett.;Paul Dolin.;Alexander C Ford.
来源: Gut. 2021年70卷4期644-653页
To generate real-world evidence for the epidemiology of gastroparesis in the UK, we evaluated the prevalence, incidence, patient characteristics and outcomes of gastroparesis in the Clinical Practice Research Datalink (CPRD) database.
1539. Prevalence, risk factors and clinical outcomes of COVID-19 in patients with a history of pancreatitis in Northern California.
作者: John Gubatan.;Steven Levitte.;Akshar Patel.;Tatiana Balabanis.;Arpita Sharma.;Elaina Jones.;Bomi Lee.;Murli Manohar.;Gayathri Swaminathan.;Walter Park.;Aida Habtezion.
来源: Gut. 2021年70卷2期440-441页 |