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1501. Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial.
作者: Michael D Hill.;Mayank Goyal.;Andrew M Demchuk.;Bijoy K Menon.;Thalia S Field.;William C Guest.;Jorg Berrouschot.;Albrecht Bormann.;Mirko Pham.;Karl G Haeusler.;Diedrick W J Dippel.;Pieter J van Doormaal.;Franziska Dorn.;Felix J Bode.;Brian A van Adel.;Demetrios J Sahlas.;Richard H Swartz.;Leodante Da Costa.;Johanna M Ospel.;Rosalie V McDonough.;Karla J Ryckborst.;Mohammed A Almekhlafi.;Kathy J Heard.;David J Garman.;Corey Adams.;Yatika Kohli.;Bridget A Schoon.;Brian H Buck.;Mario Muto.;Atif Zafar.;Hauke Schneider.;Jonathan A Grossberg.;Leonard L L Yeo.;Jason W Tarpley.;Marios-Nikos Psychogios.;Jonathan M Coutinho.;Nicola Limbucci.;Volker Puetz.;Michael E Kelly.;Bruce C V Campbell.;Sven Poli.;Alexandre Y Poppe.;Jai J Shankar.;Ronil Chandra.;Dar Dowlatshahi.;George A Lopez.;Luigi Cirillo.;Aimen Moussaddy.;Michael Devlin.;Pablo Garcia-Bermejo.;Jennifer L Mandzia.;Mona Skjelland.;Anne Hege Aamodt.;Frank L Silver.;Timothy J Kleinig.;Guglielmo Pero.;Jens Minnerup.;Ryan A McTaggart.;Ajit S Puri.;Albert H Y Chiu.;Gernot Reimann.;Gordon J Gubitz.;Marie-Christine Camden.;Seon Kyu Lee.;Eric Sauvageau.;Sibu Mundiyanapurath.;Donald F Frei.;Hana Choe.;Marcello Rocha.;Jan Gralla.;Peter Bailey.;Sebastian Fischer.;Thomas Liebig.;Konstantin Dimitriadis.;Dheeraj Gandhi.;René Chapot.;Albert Jin.;Ameer E Hassan.;Wim van Zwam.;Ilko L Maier.;Martin Wiesmann.;Wolf-Dirk Niesen.;Rajiv Advani.;Agnethe Eltoft.;Negar Asdaghi.;Cynthia Murphy.;Luca Remonda.;Darshan Ghia.;Olav Jansen.;Markus Holtmannspoetter.;Victoria Hellstern.;Karsten Witt.;Annette Fromme.;Shahid M Nimjee.;David Turkel-Parella.;Dominik Michalski.;Christian Maegerlein.;Carol Huilian Tham.;Michael Tymianski.; .
来源: Lancet. 2025年405卷10478期560-570页
In the ESCAPE-NA1 trial, treatment with nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, was associated with improved functional outcome among patients with acute ischaemic stroke due to large vessel occlusion undergoing endovascular thrombectomy without co-treatment with an intravenous thrombolytic agent. There was no benefit when intravenous thrombolytic agent co-treatment was used. We sought to confirm the clinical benefit of nerinetide in the absence of previous intravenous thrombolytic drug treatment.
1518. Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial.
作者: Giulia Argentesi.;Xilin Wu.;Alexander Ney.;Emily Goodchild.;Kate Laycock.;Yun-Ni Lee.;Russell Senanayake.;James MacFarlane.;Elisabeth Ng.;Jessica Kearney.;Sam O'Toole.;Jackie Salsbury.;Nick Carroll.;Daniel Gillett.;John A Tadross.;Alison Marker.;Edmund M Godfrey.;George Goodchild.;Jonathan P Bestwick.;Mark Gurnell.;Heok Cheow.;Stephen P Pereira.;William M Drake.;Morris J Brown.; .
来源: Lancet. 2025年405卷10479期637-647页
Unilateral aldosterone-producing adrenal adenomas (APAs) are the potentially curable cause of 5% of all cases of hypertension. Their localisation (via adrenal vein sampling [AVS]) and removal (by laparoscopic adrenalectomy) require invasive procedures that are unattractive to patients. Molecular imaging-located, endoscopic ultrasound-guided trans-gastric radiofrequency ablation (EUS-RFA) is a potential novel, minimally invasive alternative to AVS and total adrenalectomy for the treatment of APAs in the left adrenal gland, which is very close to the stomach. We aimed to determine whether EUS-RFA can safely target a heterogeneous set of such tumours without damaging the rest of the adrenal gland or adjacent organs.
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