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121. Chasing Conduction Gaps Across the Roof Line: Nearby and Overlap Better Than Appendage Pacing.
作者: Takamitsu Takagi.;Osamu Inaba.;Yukihiro Inamura.;Akira Sato.;Yuhei Isonaga.;Shinichi Tachibana.;Hiroaki Ohya.;Allan Plant.;Romain Tixier.;Josselin Duchateau.;Nicolas Derval.;Frédéric Sacher.;Mélèze Hocini.;Pierre Jaïs.;Michel Haïssaguerre.;Thomas Pambrun.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013713页
Blocking a line depends not only on the ablation but also on the validation technique. We sought to compare the performance of different pacing modes for roof line validation.
122. Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
作者: Christiane Jungen.;H Sophia Chen.;Adrianus P Wijnmaalen.;Petra Dibbets-Schneider.;Augusto Meretta.;Sebastiaan R Piers.;Yoshitaka Kimura.;Alexander F A Androulakis.;Rob J van der Geest.;Lioe-Fee de Geus-Oei.;Bart J A Mertens.;Arthur J H A Scholte.;Hildo J Lamb.;Monique R M Jongbloed.;Katja Zeppenfeld.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013150页
In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown.
123. Very Long-Term Follow-Up of Pulmonary Vein Isolation Using Cryoballoon for Catheter Ablation for Atrial Fibrillation: An 8-Year Multicenter Experience.
作者: Marco Schiavone.;Giulio Molon.;Paolo Pieragnoli.;Giuseppe Arena.;Saverio Iacopino.;Giovanni Battista Perego.;Enrico Chieffo.;Emanuele Bertaglia.;Giuseppe Stabile.;Massimiliano Manfrin.;Roberto Verlato.;Umberto Startari.;Roberto Rordorf.;Massimiliano Marini.;Gaetano Fassini.;Alessandro Costa.;Chiara Bartoli.;Jacopo Colella.;Giulia Girardengo.;Cinzia Dossena.;Francesco Rivezzi.;Assunta Iuliano.;Enrico Baldi.;Claudio Tondo.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013645页
Cryoballoon pulmonary vein isolation has become an established treatment for atrial fibrillation (AF). However, data on long-term outcomes beyond 5 years are scarce. This prospective analysis aimed to evaluate the long-term outcome after cryoballoon pulmonary vein isolation.
124. Incidence of Pacing-Induced Cardiomyopathy Among Patients With Leadless Versus Transvenous Ventricular Pacemakers.
作者: Favour E Markson.;Temidayo A Abe.;David S Frankel.;Robert D Schaller.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013800页
Frequent nonphysiological ventricular pacing and resultant pacing-induced cardiomyopathy are well characterized in transvenous pacemakers (TVP). The incidence of pacing-induced cardiomyopathy in leadless pacemakers (LP) is less understood, particularly compared with TVP.
125. 2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.
作者: Zachary T Yoneda.;Matthew O'Neill.;Diane M Crawford.;Mingfang Ao.;Lili Sun.;Majd A El-Harasis.;Lisa Pitchford.;John A Rathmacher.;Jay Montgomery.;Sharon T Shen.;Juan Carlos Estrada.;Pablo J Saavedra.;Christopher R Ellis.;Travis Richardson.;Arvindh Kangasundram.;George H Crossley.;Wendall S Akers.;Fei Ye.;Dan M Roden.;Gregory F Michaud.;M Benjamin Shoemaker.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013378页
Inflammation is a common mechanism for atrial fibrillation (AF). 2-Hydroxybenzylamine (2-HOBA) is a novel therapeutic that scavenges isolevuglandins-a downstream mediator of inflammation and oxidative stress. 2-HOBA is safe and reduces AF in mice, prompting a first-in-human pilot clinical trial.
126. Machine Learning Identification of Athlete Sport Type Through ECG Analysis.
作者: Lucas B Cofer.;Timothy W Churchill.;Rishi Bhuptani.;Aditya Inampudi.;Manav Rajvanshi.;Bjarni Atlason.;Simon S Y Shim.;Shaan Khurshid.;Eugene H Chung.;Aaron Baggish.;J Sawalla Guseh.;Kichang Lee.; .
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013677页 127. Reported Incidence of Atrial Fibrillation Varies by Ethnicity and Presentation in the Multi-Ethnic Study of Atherosclerosis.
作者: Benjamin Y Hsieh.;Ting-Wei Ernie Liao.;David T Linker.
来源: Circ Arrhythm Electrophysiol. 2025年18卷8期e013620页
Atrial fibrillation (AF) is a common cardiac arrhythmia. Its detection rates vary significantly across ethnic groups, impacting epidemiological and clinical outcomes. We aim to explore ethnic differences in self-reported versus hospital-reported AF using the MESA (Multi-Ethnic Study of Atherosclerosis).
128. Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial.
作者: Sheri J Hartman.;Andrea Z LaCroix.;Dorothy D Sears.;Loki Natarajan.;Rong W Zablocki.;Ruohui Chen.;Jeffrey S Patterson.;Lindsay Dillon.;James F Sallis.;Simon Schenk.;David W Dunstan.;Neville Owen.;Dori E Rosenberg.
来源: Circulation. 2025年152卷8期492-504页
Public health and clinical guidelines identify the importance of sedentary behaviors for cardiovascular diseases, particularly among postmenopausal women. The goal of this trial was to compare the behavioral and physiological impacts of 2 distinct approaches to changing sedentary behaviors.
129. Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.
作者: Qutuba G Karwi.;Liyan Zhang.;Keshav Gopal.;Cory S Wagg.;Kim L Ho.;Qiuyu Sun.;Sai Panidarapu.;Kaya Persad.;Betüol Altuany.;Shaden Damen.;Ezra Ketema.;Jody Levasseur.;Thomas Pulinilkunnil.;John R Ussher.;Jason R B Dyck.;Gary D Lopaschuk.
来源: Circ Heart Fail. 2025年e012012页
Elevated levels of cardiac branched-chain amino acids (BCAAs) and their metabolites, namely branched-chain keto acids (BCKAs), contribute to the development of insulin resistance, contractile dysfunction, and adverse remodeling in the failing heart. However, there is still confusion about whether BCAA or BCKA mediate these detrimental effects in the failing heart.
130. Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction.
作者: Jinxi Wang.;Daniela Sarahi Yang Bennett.;Emma J Echard.;Biyi Chen.;Grace Ciampa.;Weiyang Zhao.;Qian Shi.;Jin-Young Yoon.;Robert M Weiss.;Chad E Grueter.;Duane D Hall.;Barry London.;Long-Sheng Song.
来源: Circulation. 2025年
Calcium (Ca2+) homeostasis in cardiac fibroblasts (CFs) plays a critical role in myocardial repair and remodeling after injury. JPH (junctophilin-2; human JPH2 or mouse Jph2) is a structural protein known to regulate intracellular Ca2+ signaling and excitation-contraction coupling in cardiomyocytes. However, the role of JPH2 in CF biology remains unexplored.
131. Device-Measured Sleep Characteristics, Daily Step Count, and Cardiometabolic Health Markers: Findings From the Prospective Physical Activity, Sitting, and Sleep (ProPASS) Consortium.
作者: Wenxin Bian.;Matthew N Ahmadi.;Raaj Kishore Biswas.;Joanna M Blodgett.;Andrew J Atkin.;Hsiu-Wen Chan.;Borja Del Pozo Cruz.;Kristin Suorsa.;Esmée A Bakker.;Richard M Pulsford.;Gregore I Mielke.;Peter J Johansson.;Pasan Hettiarachchi.;Nicholas A Koemel.;Dick H J Thijssen.;Sari Stenholm.;Gita D Mishra.;Armando Teixeira-Pinto.;Vegar Rangul.;Lauren B Sherar.;Ulf Ekelund.;Alun D Hughes.;I-Min Lee.;Peter A Cistulli.;Andreas Holtermann.;Annemarie Koster.;Mark Hamer.;Emmanuel Stamatakis.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷8期e011873页
Sleep and physical activity (PA) are important lifestyle-related behaviors that impact cardiometabolic health. This study investigated the joint associations of daily step count and sleep patterns (regularity and duration) with cardiometabolic biomarkers in adults.
132. Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant.
作者: Justin L Grodin.;Anand Gupta.;Ishan Rison.;Julia Kozlitina.;Lorena Saelices-Gomez.;Saket Girotra.;Amil M Shah.;Lori R Roth.;Jan M Griffin.;Mark H Drazner.;W H Wilson Tang.;Mathew S Maurer.;James A de Lemos.
来源: Circ Genom Precis Med. 2025年18卷4期e004911页
To better define the importance of the amyloidogenic p.V142I TTR allele across the life span of a carrier, we leveraged data from All of Us to provide a generalizable assessment of the population-level burden of cardiovascular risk and estimate the age at disease onset.
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