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1262. Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers.
作者: Han-Mo Chiu.;Grace Hsiao-Hsuan Jen.;Ying-Wei Wang.;Jean Ching-Yuan Fann.;Chen-Yang Hsu.;Ya-Chung Jeng.;Amy Ming-Fang Yen.;Sherry Yueh-Hsia Chiu.;Sam Li-Sheng Chen.;Wen-Feng Hsu.;Yi-Chia Lee.;Ming-Shiang Wu.;Chien-Yuan Wu.;Yann-Yuh Jou.;Tony Hsiu-Hsi Chen.
来源: Gut. 2021年70卷12期2321-2329页
To measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening.
1263. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
作者: Shumei Song.;Qiongrong Chen.;Yuan Li.;Guang Lei.;Ailing Scott.;Longfei Huo.;Cordelia Y Li.;Jeannelyn Santiano Estrella.;Arlene Correa.;Melissa Pool Pizzi.;Lang Ma.;Jiankang Jin.;Bin Liu.;Ying Wang.;Lianchun Xiao.;Wayne L Hofstetter.;Jeffrey H Lee.;Brian Weston.;Manoop Bhutani.;Namita Shanbhag.;Randy L Johnson.;Boyi Gan.;Shaozhong Wei.;Jaffer A Ajani.
来源: Gut. 2021年70卷12期2238-2248页
Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy resistance. We sought to elucidate the antitumour action of a BCL-2 inhibitor, AT101 in GEC in vitro, in vivo and in a clinical trial.
1264. Transcolonic endoscopic appendectomy: a novel natural orifice transluminal endoscopic surgery (NOTES) technique for the sessile serrated lesions involving the appendiceal orifice.
作者: Tao Chen.;Aiping Xu.;Jingjing Lian.;Yuan Chu.;Haibin Zhang.;Meidong Xu.
来源: Gut. 2021年70卷10期1812-1814页 1265. Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease.
作者: Jonel Trebicka.;Wenyi Gu.;Victor de Ledinghen.;Christophe Aubé.;Aleksander Krag.;Michael Praktiknjo.;Laurent Castera.;Jerome Dumortier.;David Josef Maria Bauer.;Mireen Friedrich-Rust.;Stanislas Pol.;Ivica Grgurevic.;Rongqin Zheng.;Sven Francque.;Halima Gottfriedovà.;Sanda Mustapic.;Ioan Sporea.;Annalisa Berzigotti.;Frank Erhard Uschner.;Benedikt Simbrunner.;Maxime Ronot.;Christophe Cassinotto.;Maria Kjaergaard.;Filipe Andrade.;Martin Schulz.;Georg Semmler.;Ida Tjesic Drinkovic.;Johannes Chang.;Maximilian Joseph Brol.;Pierre Emmanuel Rautou.;Thomas Vanwolleghem.;Christian P Strassburg.;Jerome Boursier.;Philip Georg Ferstl.;Ditlev Nytoft Rasmussen.;Thomas Reiberger.;Valerie Vilgrain.;Aymeric Guibal.;Olivier Guillaud.;Stefan Zeuzem.;Camille Vassord.;Xue Lu.;Luisa Vonghia.;Renata Senkerikova.;Alina Popescu.;Cristina Margini.;Wenping Wang.;Maja Thiele.;Chrisitan Jansen.
来源: Gut. 2022年71卷2期402-414页
Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients.
1266. Artificial intelligence in GI endoscopy: stumbling blocks, gold standards and the role of endoscopy societies.
作者: Rüdiger Schmitz.;Rene Werner.;Alessandro Repici.;Raf Bisschops.;Alexander Meining.;Michael Zornow.;Helmut Messmann.;Cesare Hassan.;Prateek Sharma.;Thomas Rösch.
来源: Gut. 2022年71卷3期451-454页 1267. SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting.
作者: Corey A Siegel.;Gil Y Melmed.;Dermot Pb McGovern.;Victoria Rai.;Florian Krammer.;David T Rubin.;Maria T Abreu.;Marla C Dubinsky.; .; .
来源: Gut. 2021年70卷4期635-640页 1268. Impaired antibacterial response of liver sinusoidal Vγ9+Vδ2+ T cells in patients with chronic liver disease.
作者: Min-Seok Rha.;Ji Won Han.;June-Young Koh.;Ha Seok Lee.;Jong Hoon Kim.;Kyungjoo Cho.;Soon Il Kim.;Myoung Soo Kim.;Jae Geun Lee.;Su-Hyung Park.;Dong Jin Joo.;Jun Yong Park.;Eui-Cheol Shin.
来源: Gut. 2022年71卷3期605-615页
The liver acts as a frontline barrier against diverse gut-derived pathogens, and the sinusoid is the primary site of liver immune surveillance. However, little is known about liver sinusoidal immune cells in the context of chronic liver disease (CLD). Here, we investigated the antibacterial capacity of liver sinusoidal γδ T cells in patients with various CLDs.
1269. Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
作者: Benjamin Goeppert.;Damian Stichel.;Reka Toth.;Sarah Fritzsche.;Moritz Anton Loeffler.;Anna Melissa Schlitter.;Olaf Neumann.;Yassen Assenov.;Monika Nadja Vogel.;Arianeb Mehrabi.;Katrin Hoffmann.;Bruno Köhler.;Christoph Springfeld.;Dieter Weichenhan.;Christoph Plass.;Irene Esposito.;Peter Schirmacher.;Andreas von Deimling.;Stephanie Roessler.
来源: Gut. 2022年71卷2期391-401页
A detailed understanding of the molecular alterations in different forms of cholangiocarcinogenesis is crucial for a better understanding of cholangiocarcinoma (CCA) and may pave the way to early diagnosis and better treatment options.
1270. Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn's disease.
作者: Ren Mao.;Genevieve Doyon.;Ilyssa O Gordon.;Jiannan Li.;Sinan Lin.;Jie Wang.;Thi Hong Nga Le.;Michael Elias.;Satya Kurada.;Brian Southern.;Mitchell Olman.;Minhu Chen.;Shuai Zhao.;Dina Dejanovic.;Jyotsna Chandra.;Pranab K Mukherjee.;Gail West.;David R Van Wagoner.;Claudio Fiocchi.;Florian Rieder.
来源: Gut. 2022年71卷1期55-67页
Creeping fat, the wrapping of mesenteric fat around the bowel wall, is a typical feature of Crohn's disease, and is associated with stricture formation and bowel obstruction. How creeping fat forms is unknown, and we interrogated potential mechanisms using novel intestinal tissue and cell interaction systems.
1272. Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial.
作者: Anat Yaskolka Meir.;Ehud Rinott.;Gal Tsaban.;Hila Zelicha.;Alon Kaplan.;Philip Rosen.;Ilan Shelef.;Ilan Youngster.;Aryeh Shalev.;Matthias Blüher.;Uta Ceglarek.;Michael Stumvoll.;Kieran Tuohy.;Camilla Diotallevi.;Urska Vrhovsek.;Frank Hu.;Meir Stampfer.;Iris Shai.
来源: Gut. 2021年70卷11期2085-2095页
To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss.
1273. Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial.
作者: Jeroen M Schuitenmaker.;Froukje B van Hoeij.;Marlies P Schijven.;Jan Tack.;José M Conchillo.;Eric J Hazebroek.;André J P M Smout.;Albert J Bredenoord.
来源: Gut. 2022年71卷1期10-15页
There is no evidence-based treatment for persistent dysphagia after laparoscopic fundoplication. The aim of this study was to evaluate the effect of pneumatic dilation on persistent dysphagia after laparoscopic fundoplication.
1274. NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
作者: Mabrouka Salem.;Joanna Lecka.;Julie Pelletier.;Danielle Gomes Marconato.;Aline Dumas.;Luc Vallières.;Gaetan Brochu.;Bernard Robaye.;Christian Jobin.;Jean Sévigny.
来源: Gut. 2022年71卷1期43-54页
Nucleotides are danger signals that activate inflammatory responses via binding P2 receptors. The nucleoside triphosphate diphosphohydrolase-8 (NTPDase8) is an ectonucleotidase that hydrolyses P2 receptor ligands. We investigated the role of NTPDase8 in intestinal inflammation.
1275. Novel scheme for non-invasive gut bioinformation acquisition with a magnetically controlled sampling capsule endoscope.
作者: Zhen Ding.;Weijun Wang.;Kun Zhang.;Fanhua Ming.;Tianyi Yangdai.;Tao Xu.;Huiying Shi.;Yuhui Bao.;Hailing Yao.;Hangyu Peng.;Chaoqun Han.;Weiwei Jiang.;Jun Liu.;Xiaohua Hou.;Rong Lin.
来源: Gut. 2021年70卷12期2297-2306页
Intestinal flora and metabolites are associated with multiple systemic diseases. Current approaches for acquiring information regarding microbiota/metabolites have limitations. We aimed to develop a precise magnetically controlled sampling capsule endoscope (MSCE) for the convenient, non-invasive and accurate acquisition of digestive bioinformation for disease diagnosis and evaluation.
1277. Rescue of male fertility following faecal microbiota transplantation from alginate oligosaccharide-dosed mice.
作者: Cong Zhang.;Bohui Xiong.;Liang Chen.;Wei Ge.;Shen Yin.;Yanni Feng.;Zhongyi Sun.;Qingyuan Sun.;Yong Zhao.;Wei Shen.;Hongfu Zhang.
来源: Gut. 2021年70卷11期2213-2215页 1279. Young-onset colorectal cancer risk among individuals with iron-deficiency anaemia and haematochezia.
作者: Joshua Demb.;Lin Liu.;Caitlin C Murphy.;Chyke A Doubeni.;María Elena Martínez.;Samir Gupta.
来源: Gut. 2020年70卷8期1529-37页
Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC.
1280. Multicentre, prospective, randomised study comparing the diagnostic yield of colon capsule endoscopy versus CT colonography in a screening population (the TOPAZ study).
作者: Brooks D Cash.;Mark R Fleisher.;Steven Fern.;Elizabeth Rajan.;Robyn Haithcock.;David M Kastenberg.;David Pound.;Neofytos P Papageorgiou.;Ignacio Fernández-Urién.;Ira J Schmelkin.;Douglas K Rex.
来源: Gut. 2021年70卷11期2115-2122页
Colon capsule endoscopy (CCE) has shown promise for colorectal neoplasia detection compared with optical colonoscopy (OC), but has not been compared with other screening tests in average risk screening patients.
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