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1241. Maintenance therapy with infliximab or vedolizumab in IBD is not associated with increased SARS-CoV-2 seroprevalence: UK experience in the 2020 pandemic.
作者: Colleen Gc McGregor.;Alex Adams.;Ross Sadler.;Carolina V Arancibia-Cárcamo.;Rebecca Palmer.;Tim Ambrose.;Oliver Brain.;Alissa Walsh.;Paul Klenerman.;Simon Pl Travis.;Nicholas M Croft.;James O Lindsay.;Jack Satsangi.
来源: Gut. 2021年70卷12期2398-2400页 1242. Endoscopic transmural route for dissection of gastric submucosal tumors with extraluminal growth: experience in two cases.
作者: Xinyang Liu.;Tianyin Chen.;Jing Cheng.;Pingting Gao.;Quanlin Li.;Weifeng Chen.;Yiqun Zhang.;Pinghong Zhou.;Jianwei Hu.
来源: Gut. 2021年70卷11期2052-2054页 1243. Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.
作者: Xiaoting Sun.;Xingkang He.;Yin Zhang.;Kayoko Hosaka.;Patrik Andersson.;Jing Wu.;Jieyu Wu.;Xu Jing.;Qiqiao Du.;Xiaoli Hui.;Bo Ding.;Ziheng Guo.;An Hong.;Xuan Liu.;Yan Wang.;Qing Ji.;Rudi Beyaert.;Yunlong Yang.;Qi Li.;Yihai Cao.
来源: Gut. 2022年71卷1期129-147页
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy.
1244. Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence.
作者: Marianne Rebecca Spalinger.;Ali Shawki.;Pritha Chatterjee.;Vinicius Canale.;Alina Santos.;Anica Sayoc-Becerra.;Michael Scharl.;Michel L Tremblay.;James Borneman.;Declan F McCole.
来源: Gut. 2022年71卷1期89-99页
Alterations in the intestinal microbiota are linked with a wide range of autoimmune and inflammatory conditions, including inflammatory bowel diseases (IBD), where pathobionts penetrate the intestinal barrier and promote inflammatory reactions. In patients with IBD, the ability of intestinal macrophages to efficiently clear invading pathogens is compromised resulting in increased bacterial translocation and excessive immune reactions. Here, we investigated how an IBD-associated loss-of-function variant in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene, or loss of PTPN2 expression affected the ability of macrophages to respond to invading bacteria.
1245. Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma.
作者: Camille Péneau.;Sandrine Imbeaud.;Tiziana La Bella.;Theo Z Hirsch.;Stefano Caruso.;Julien Calderaro.;Valerie Paradis.;Jean-Frederic Blanc.;Eric Letouzé.;Jean-Charles Nault.;Giuliana Amaddeo.;Jessica Zucman-Rossi.
来源: Gut. 2022年71卷3期616-626页
Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC) worldwide. HBV directly drives carcinogenesis through integrations in the human genome. This study aimed to precisely characterise HBV integrations, in relation with viral and host genomics and clinical features.
1247. Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn.
作者: Kaiyu Xu.;Xuxuan Gao.;Genghong Xia.;Muxuan Chen.;Nianyi Zeng.;Shan Wang.;Chao You.;Xiaolin Tian.;Huiling Di.;Wenli Tang.;Pan Li.;Huidi Wang.;Xiuli Zeng.;Chuhong Tan.;Fanguo Meng.;Hailong Li.;Yan He.;Hongwei Zhou.;Jia Yin.
来源: Gut. 2021年
Stroke is a leading cause of death and disability worldwide. Neuroprotective approaches have failed in clinical trials, thus warranting therapeutic innovations with alternative targets. The gut microbiota is an important contributor to many risk factors for stroke. However, the bidirectional interactions between stroke and gut microbiota remain largely unknown.
1248. Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation.
作者: Yi Rang Na.;Daun Jung.;Michelle Stakenborg.;Hyeri Jang.;Gyo Jeong Gu.;Mi Reu Jeong.;Soo Youn Suh.;Hak Jae Kim.;Yoon Hey Kwon.;Tae Sik Sung.;Seung Bum Ryoo.;Kyu Joo Park.;Jong Pil Im.;Ji Yong Park.;Yun Sang Lee.;Heonjong Han.;Boyoun Park.;Sungwook Lee.;Daesik Kim.;Ho Su Lee.;Isabelle Cleynen.;Gianluca Matteoli.;Seung Hyeok Seok.
来源: Gut. 2021年70卷12期2249-2260页
Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features in the pathogenesis of inflammatory bowel disease (IBD). Intestinal macrophages are vital in the process of inflammation resolution, but the mechanisms underlying their mucosal healing capacity remain elusive.
1249. SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study.
作者: Sanjay Pandanaboyana.;John Moir.;John S Leeds.;Kofi Oppong.;Aditya Kanwar.;Ahmed Marzouk.;Ajay Belgaumkar.;Ajay Gupta.;Ajith K Siriwardena.;Ali Raza Haque.;Altaf Awan.;Anita Balakrishnan.;Arab Rawashdeh.;Bogdan Ivanov.;Chetan Parmar.;Christopher M Halloran.;Clifford Caruana.;Cynthia-Michelle Borg.;Dhanny Gomez.;Dimitrios Damaskos.;Dimitrios Karavias.;Guy Finch.;Husam Ebied.;James K Pine.;James R A Skipworth.;James Milburn.;Javed Latif.;Jeyakumar Ratnam Apollos.;Jihène El Kafsi.;John A Windsor.;Keith Roberts.;Kelvin Wang.;Krish Ravi.;Maria V Coats.;Marianne Hollyman.;Mary Phillips.;Michael Okocha.;Michael Sj Wilson.;Nadeem A Ameer.;Nagappan Kumar.;Nehal Shah.;Pierfrancesco Lapolla.;Connor Magee.;Bilal Al-Sarireh.;Raimundas Lunevicius.;Rami Benhmida.;Rishi Singhal.;Srinivasan Balachandra.;Semra Demirli Atıcı.;Shameen Jaunoo.;Simon Dwerryhouse.;Tamsin Boyce.;Vasileios Charalampakis.;Venkat Kanakala.;Zaigham Abbas.;Manu Nayar.; .
来源: Gut. 2021年70卷6期1061-1069页
There is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.
1251. Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?
作者: Ramy Younes.;Olivier Govaere.;Salvatore Petta.;Luca Miele.;Dina Tiniakos.;Alastair Burt.;Ezio David.;Fabio Maria Vecchio.;Marco Maggioni.;Daniela Cabibi.;Duncan McLeod.;Maria Jesus Pareja.;Anna Ludovica Fracanzani.;Rocio Aller.;Chiara Rosso.;Javier Ampuero.;Rocío Gallego-Durán.;Angelo Armandi.;Gian Paolo Caviglia.;Marco Y W Zaki.;Antonio Liguori.;Paolo Francione.;Grazia Pennisi.;Antonio Grieco.;Giovanni Birolo.;Piero Fariselli.;Mohammed Eslam.;Luca Valenti.;Jacob George.;Manuel Romero-Gómez.;Quentin Mark Anstee.;Elisabetta Bugianesi.
来源: Gut. 2022年71卷2期382-390页
The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis of Caucasian lean subjects with NAFLD.
1252. Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects.
作者: M Gordian Adam.;Georg Beyer.;Nicole Christiansen.;Beate Kamlage.;Christian Pilarsky.;Marius Distler.;Tim Fahlbusch.;Ansgar Chromik.;Fritz Klein.;Marcus Bahra.;Waldemar Uhl.;Robert Grützmann.;Ujjwal M Mahajan.;Frank U Weiss.;Julia Mayerle.;Markus M Lerch.
来源: Gut. 2021年70卷11期2150-2158页
Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to organ dysfunction, chronic pain, an increased risk for pancreatic cancer and considerable morbidity. Due to a lack of specific biomarkers, diagnosis is based on symptoms and specific but insensitive imaging features, preventing an early diagnosis and appropriate management.
1253. COVID-19 and endoscopic services: the impact of delays in therapeutic colonoscopies on patients.
作者: Syazeddy Samani.;Nasir Mir.;David N Naumann.;Michael Ding.;Sharad Karandikar.;Jason Goh.;Marietta Iacucci.;Marcus Mottershead.;Vanja Giljaca.
来源: Gut. 2021年70卷10期2019-2020页 1254. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
作者: Ane Olazagoitia-Garmendia.;Linda Zhang.;Paula Mera.;Julie K Godbout.;Maialen Sebastian-DelaCruz.;Iraia Garcia-Santisteban.;Luis Manuel Mendoza.;Alain Huerta.;Iñaki Irastorza.;Govind Bhagat.;Peter H Green.;Laura Herrero.;Dolors Serra.;Jose Antonio Rodriguez.;Elena F Verdu.;Chuan He.;Jose Ramon Bilbao.;Ainara Castellanos-Rubio.
来源: Gut. 2022年71卷1期68-76页
Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten free diet. Human leucocyte antigen (HLA) genes and several non-HLA regions have been associated with the genetic susceptibility to CD, but their role in the pathogenesis of the disease is still essentially unknown, making it complicated to develop much needed non-dietary treatments. Here, we describe the functional involvement of a CD-associated single-nucleotide polymorphism (SNP) located in the 5'UTR of XPO1 in the inflammatory environment characteristic of the coeliac intestinal epithelium.
1257. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways.
作者: María Arnoriaga-Rodríguez.;Jordi Mayneris-Perxachs.;Oren Contreras-Rodríguez.;Aurelijus Burokas.;Juan-Antonio Ortega-Sanchez.;Gerard Blasco.;Claudia Coll.;Carles Biarnés.;Anna Castells-Nobau.;Josep Puig.;Josep Garre-Olmo.;Rafel Ramos.;Salvador Pedraza.;Ramon Brugada.;Joan C Vilanova.;Joaquín Serena.;Jordi Barretina.;Jordi Gich.;Vicente Pérez-Brocal.;Andrés Moya.;Xavier Fernández-Real.;Lluis Ramio-Torrentà.;Reinald Pamplona.;Joaquim Sol.;Mariona Jové.;Wifredo Ricart.;Manuel Portero-Otin.;Rafael Maldonado.;Jose Manuel Fernández-Real.
来源: Gut. 2021年70卷12期2283-2296页
Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits.
1258. Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study.
作者: Sabine Weber.;Johannes C Hellmuth.;Clemens Scherer.;Maximilian Muenchhoff.;Julia Mayerle.;Alexander L Gerbes.
来源: Gut. 2021年70卷10期1925-1932页
Liver injury has frequently been reported in COVID-19 patients. The clinical relevance of liver injury related to SARS-CoV-2 infection remains unclear with a need for prospective studies on the impact of liver function test (LFT) abnormalities at baseline.
1259. Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.
作者: Lena Allweiss.;Katja Giersch.;Andrea Pirosu.;Tassilo Volz.;Robert C Muench.;Rudolf K Beran.;Stephan Urban.;Hassan Javanbakht.;Simon P Fletcher.;Marc Lütgehetmann.;Maura Dandri.
来源: Gut. 2022年71卷2期372-381页
Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-IFNα) on the viral regulatory HBx protein and the structural maintenance of chromosome 5/6 complex (SMC5/6), a host factor suppressing cccDNA transcription. In particular, we assessed whether interventions lowering HBV transcripts can achieve and maintain silencing of cccDNA transcription in vivo.
1260. Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut-testis axis.
作者: Teng Zhang.;Peng Sun.;Qi Geng.;Haitao Fan.;Yutian Gong.;Yanting Hu.;Liying Shan.;Yuanchao Sun.;Wei Shen.;Yang Zhou.
来源: Gut. 2022年71卷1期78-87页
Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We aim to uncover the direct evidence involving the gut-testis axis in the aetiology of impaired spermatogenesis.
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