1141. Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer.
作者: Ravindra Uppaluri.;Robert I Haddad.;Yungan Tao.;Christophe Le Tourneau.;Nancy Y Lee.;William Westra.;Rebecca Chernock.;Makoto Tahara.;Kevin J Harrington.;Arkadiy L Klochikhin.;Irene Braña.;Gustavo Vasconcelos Alves.;Brett G M Hughes.;Marc Oliva.;Iane Pinto Figueiredo Lima.;Tsutomu Ueda.;Tomasz Rutkowski.;Ursula Schroeder.;Paul-Stefan Mauz.;Thorsten Fuereder.;Simon Laban.;Nobuhiko Oridate.;Aron Popovtzer.;Nicolas Mach.;Yevhen Korobko.;Diogo Alpuim Costa.;Anupama Hooda-Nehra.;Cristina P Rodriguez.;R Bryan Bell.;Cole Manschot.;Kimberly Benjamin.;Burak Gumuscu.;Douglas Adkins.; .
来源: N Engl J Med. 2025年393卷1期37-50页
The benefit of the addition of perioperative pembrolizumab to standard care with surgery and adjuvant therapy for patients with locally advanced head and neck squamous-cell carcinoma (HNSCC) is unclear.
1152. Three Cases of Vertical Transmission of Clade Ib Mpox Virus.
作者: Emmanuel Hasivirwe Vakaniaki.;Nono-Raymond Swar Kuispond.;Yuichiro Hirata.;Eugene Bangwen.;Isabel Brosius.;Eddy Kinganda-Lusamaki.;Seiya Ozono.;Harutaka Katano.;Laurent Gabanga Ndunge.;Noella Mulopo-Mukanya.;Jean-Claude Tshomba.;Elise De Vos.;Christophe Van Dijck.;Papy Munganga.;Guy Mukari.;Yves Mujula.;Divin Mazambi Mambo.;Steeven Bilembo Kitwanda.;Nadine Maliyamungu-Bubala.;Léandre Mutimbwa-Mambo.;Ian Crozier.;Lori E Dodd.;Olivier Tshiani-Mbaya.;Bienvenu Massamba Lebwaze.;Espoir Bwenge Malembaka.;Isaac Barhishindi.;Susanne Krasemann.;Robert Colebunders.;Patrick D M C Katoto.;Sheila Makiala-Mandanda.;Jason Kindrachuk.;Anne W Rimoin.;Jean-Jacques Muyembe-Tamfum.;Daniel Mukadi-Bamuleka.;Tony Wawina-Bokalanga.;Sabin Sabiti Nundu.;Tadaki Suzuki.;Raphaël Bulakali Chirimwami.;Laurens Liesenborghs.;Placide Mbala-Kingebeni.
来源: N Engl J Med. 2025年392卷23期2385-2387页 1158. Bevacizumab and Erlotinib in Hereditary and Sporadic Papillary Kidney Cancer.
作者: Ramaprasad Srinivasan.;Sandeep Gurram.;Eric A Singer.;Abhinav Sidana.;Munjid Al Harthy.;Mark W Ball.;Julia C Friend.;Lisa Mac.;Erin Purcell.;Cathy D Vocke.;Christopher J Ricketts.;Heidi H Kong.;Edward W Cowen.;Ashkan A Malayeri.;Joanna H Shih.;Maria J Merino.;W Marston Linehan.
来源: N Engl J Med. 2025年392卷23期2346-2356页
Hereditary leiomyomatosis and renal-cell cancer (HLRCC) is an inherited disorder characterized by germline pathogenic variants in the gene encoding fumarate hydratase and an increased risk of papillary renal-cell carcinoma. No effective therapy is known for patients with advanced HLRCC-associated papillary renal-cell carcinoma, and most patients die from progressive disease.
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