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1081. Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism.
Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts of emulsifier consumption on gut microbiota include depletion of the health-associated mucus-fortifying bacteria, Akkermansia muciniphila.
1082. S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.
作者: Xia Wang.;Hongyang Huang.;Karen Man-Fong Sze.;Jin Wang.;Lu Tian.;Jingyi Lu.;Yu-Man Tsui.;Hoi Tang Ma.;Eva Lee.;Ao Chen.;Joyce Lee.;Ying Wang.;Judy Wai Ping Yam.;Tan-To Cheung.;Xinyuan Guan.;Irene Oi-Lin Ng.
来源: Gut. 2023年72卷7期1370-1384页
Growing evidence indicates that tumour cells exhibit characteristics similar to their lineage progenitor cells. We found that S100 calcium binding protein A10 (S100A10) exhibited an expression pattern similar to that of liver progenitor genes. However, the role of S100A10 in hepatocellular carcinoma (HCC) progression is unclear. Furthermore, extracellular vesicles (EVs) are critical mediators of tumourigenesis and metastasis, but the extracellular functions of S100A10, particularly those related to EVs (EV-S100A10), are unknown.
1083. Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis.
作者: Guoying Zhu.;Steven J Wilhelm.;Leah G George.;Brett M Cassidy.;Sammy Zino.;Cliff J Luke.;Mina Hanna.;Stephen Stone.;Nhung Phan.;Neel Matiwala.;Samuel J Ballentine.;Mark E Lowe.;Xunjun Xiao.
来源: Gut. 2023年72卷7期1340-1354页
Increasing evidence implicates mutation-induced protein misfolding and endoplasm reticulum (ER) stress in the pathophysiology of chronic pancreatitis (CP). The paucity of animal models harbouring genetic risk variants has hampered our understanding of how misfolded proteins trigger CP. We previously showed that pancreatic triglyceride lipase (PNLIP) p.T221M, a variant associated with steatorrhoea and possibly CP in humans, misfolds and elicits ER stress in vitro suggesting proteotoxicity as a potential disease mechanism. Our objective was to create a mouse model to determine if PNLIP p.T221M causes CP and to define the mechanism.
1084. Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis.
作者: Juliane Glaubitz.;Anika Wilden.;Fabian Frost.;Sabine Ameling.;Georg Homuth.;Hala Mazloum.;Malte Christoph Rühlemann.;Corinna Bang.;Ali A Aghdassi.;Christoph Budde.;Tilmann Pickartz.;Andre Franke.;Barbara M Bröker.;Uwe Voelker.;Julia Mayerle.;Markus M Lerch.;Frank-Ulrich Weiss.;Matthias Sendler.
来源: Gut. 2023年72卷7期1355-1369页
In acute pancreatitis (AP), bacterial translocation and subsequent infection of pancreatic necrosis are the main risk factors for severe disease and late death. Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease. Here, we studied the role of the Treg/Th17 balance for maintaining the intestinal barrier function in a mouse model of severe AP.
1085. Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis.
作者: Yishay Pinto.;Sigal Frishman.;Sondra Turjeman.;Adi Eshel.;Meital Nuriel-Ohayon.;Oshrit Shrossel.;Oren Ziv.;William Walters.;Julie Parsonnet.;Catherine Ley.;Elizabeth L Johnson.;Krithika Kumar.;Ron Schweitzer.;Soliman Khatib.;Faiga Magzal.;Efrat Muller.;Snait Tamir.;Kinneret Tenenbaum-Gavish.;Samuli Rautava.;Seppo Salminen.;Erika Isolauri.;Or Yariv.;Yoav Peled.;Eran Poran.;Joseph Pardo.;Rony Chen.;Moshe Hod.;Elhanan Borenstein.;Ruth E Ley.;Betty Schwartz.;Yoram Louzoun.;Eran Hadar.;Omry Koren.
来源: Gut. 2023年72卷5期918-928页
Gestational diabetes mellitus (GDM) is a condition in which women without diabetes are diagnosed with glucose intolerance during pregnancy, typically in the second or third trimester. Early diagnosis, along with a better understanding of its pathophysiology during the first trimester of pregnancy, may be effective in reducing incidence and associated short-term and long-term morbidities.
1087. Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study.
作者: Adam S Faye.;Kristine Højgaard Allin.;Aske T Iversen.;Manasi Agrawal.;Jeremiah Faith.;Jean-Frederic Colombel.;Tine Jess.
来源: Gut. 2023年72卷4期663-670页
There is an increasing incidence of inflammatory bowel disease (IBD) for which environmental factors are suspected. Antibiotics have been associated with development of IBD in earlier generations, but their influence on IBD risk in adults is uncertain.
1089. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN.
作者: Eileen Morgan.;Melina Arnold.;A Gini.;V Lorenzoni.;C J Cabasag.;Mathieu Laversanne.;Jerome Vignat.;Jacques Ferlay.;Neil Murphy.;Freddie Bray.
来源: Gut. 2023年72卷2期338-344页
Colorectal cancer (CRC) is the third most common cancer worldwide. The geographical and temporal burden of this cancer provides insights into risk factor prevalence and progress in cancer control strategies. We examine the current and future burden of CRC in 185 countries in 2020 and 2040.
1090. Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis.
作者: Haijian Sun.;Yunke Guo.;Haidan Wang.;Ailing Yin.;Jing Hu.;Tianjie Yuan.;Shuxin Zhou.;Weichen Xu.;Peng Wei.;Shusheng Yin.;Panru Liu.;Xi Guo.;Yizhao Tang.;Yujiao Yan.;Zichen Luo.;Majie Wang.;Qingqing Liang.;Peng Wu.;Aifeng Zhang.;Zhuxiu Zhou.;Yueyue Chen.;Yongming Li.;Jing Li.;Jinjun Shan.;Wei Zhou.
来源: Gut. 2023年72卷9期1664-1677页
Gut microbiota dysbiosis is closely linked to the pathogenesis of rheumatoid arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the development of RA.
1091. Diagnostic accuracy of FibroScan-AST (FAST) score for the non-invasive identification of patients with fibrotic non-alcoholic steatohepatitis: a systematic review and meta-analysis.
作者: Federico Ravaioli.;Elton Dajti.;Alessandro Mantovani.;Philip Noel Newsome.;Giovanni Targher.;Antonio Colecchia.
来源: Gut. 2023年72卷7期1399-1409页
A simple combined score with liver stiffness, controlled attenuation parameter and serum aspartate aminotransferase (AST), the FibroScan-AST (FAST) score, has been proposed to non-invasively identify patients with fibrotic non-alcoholic steatohepatitis (NASH). We performed a systematic review and meta-analysis of published studies to evaluate the overall diagnostic accuracy of the FAST score in identifying patients with fibrotic NASH.
1092. Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences.
作者: Shuling Chen.;Cheng Huang.;Guanrui Liao.;Huichuan Sun.;Yubin Xie.;Changyi Liao.;Jianping Wang.;Minghui He.;Huanjing Hu.;Zihao Dai.;Xiaoxue Ren.;Xuezhen Zeng.;Zhilong Lin.;Guo-Pei Zhang.;Wenxuan Xie.;Shunli Shen.;Shaoqiang Li.;Sui Peng.;Dong-Ming Kuang.;Qiang Zhao.;Dan G Duda.;Ming Kuang.
来源: Gut. 2023年72卷6期1196-1210页
Revealing the single-cell immune ecosystems in true versus de novo hepatocellular carcinoma (HCC) recurrences could help the optimal development of immunotherapies.
1094. MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression.
作者: Yaojie Fu.;Bryan Mackowiak.;Dechun Feng.;Hongkun Lu.;Yukun Guan.;Taylor Lehner.;Hongna Pan.;Xin Wei Wang.;Yong He.;Bin Gao.
来源: Gut. 2023年72卷10期1942-1958页
The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis and immunosuppression provides some benefits only for a subset of patients with HCC, thus optimised therapeutic regimens are unmet needs, which require a thorough understanding of the underlying mechanisms by which tumour cells orchestrate an inflamed tumour microenvironment with significant myeloid cell infiltration. MicroRNA-223 (miR-223) is highly expressed in myeloid cells but its role in regulating tumour microenvironment remains unknown.
1096. Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain.
作者: Caroline J Tuck.;Amal Abu Omar.;Giada De Palma.;Samira Osman.;Nestor N Jiménez-Vargas.;Yang Yu.;Sean Mp Bennet.;Cintya Lopez-Lopez.;Josue O Jaramillo-Polanco.;Corey C Baker.;Aidan Sw Bennett.;Mabel Guzman-Rodriguez.;Quentin Tsang.;Taylor Alward.;Sebastien Rolland.;Celine Morissette.;Elena F Verdu.;Premysl Bercik.;Stephen J Vanner.;Alan E Lomax.;David E Reed.
来源: Gut. 2022年
Dietary therapies for irritable bowel syndrome (IBS) have received increasing interest but predicting which patients will benefit remains a challenge due to a lack of mechanistic insight. We recently found evidence of a role for the microbiota in dietary modulation of pain signalling in a humanised mouse model of IBS. This randomised cross-over study aimed to test the hypothesis that pain relief following reduced consumption of fermentable carbohydrates is the result of changes in luminal neuroactive metabolites.
1098. AGR2 protein expression in colorectal tumour epithelialcompartment.
作者: Eric Chevet.;F Bassal.;Stéphanie Beq.;Benjamin Bonhomme.;Emeric Boisteau.;Julien Calloch.;Dominique Cazals-Hatem.;Frederic Delom.;Delphine Fessart.;Serge Evrard.;Roman Hrstka.;Ted Hupp.;Astrid Lièvre.;Edouard Louis.;Jeremie Mariau.;Marie-Alice Meuwis.;Eric Ogier-Denis.;Valerie Paradis.;Simon Pernot.;R Pineau.;Xavier Treton.;Valerie Velasco.;Sophie Vieujean.
来源: Gut. 2022年72卷12期2385-6页 1099. Post COVID-19 irritable bowel syndrome.
作者: Giovanni Marasco.;Cesare Cremon.;Maria Raffaella Barbaro.;Giulia Cacciari.;Francesca Falangone.;Anna Kagramanova.;Dmitry Bordin.;Vasile Drug.;Egidia Miftode.;Pietro Fusaroli.;Salem Youssef Mohamed.;Chiara Ricci.;Massimo Bellini.;Mohammed Masudur Rahman.;Luigi Melcarne.;Javier Santos.;Beatriz Lobo.;Serhat Bor.;Suna Yapali.;Deniz Akyol.;Ferdane Pirincci Sapmaz.;Yonca Yilmaz Urun.;Tugce Eskazan.;Altay Celebi.;Huseyin Kacmaz.;Berat Ebik.;Hatice Cilem Binicier.;Mehmet Sait Bugdayci.;Munkhtsetseg Banzragch Yağcı.;Husnu Pullukcu.;Berrin Yalınbas Kaya.;Ali Tureyen.;İbrahim Hatemi.;Elif Sitre Koc.;Goktug Sirin.;Ali Riza Calıskan.;Goksel Bengi.;Esra Ergun Alıs.;Snezana Lukic.;Meri Trajkovska.;Keren Hod.;Dan Dumitrascu.;Antonello Pietrangelo.;Elena Corradini.;Magnus Simren.;Jessica Sjölund.;Navkiran Tornkvist.;Uday C Ghoshal.;Olga Kolokolnikova.;Antonio Colecchia.;Jordi Serra.;Giovanni Maconi.;Roberto De Giorgio.;Silvio Danese.;Piero Portincasa.;Antonio Di Sabatino.;Marcello Maggio.;Elena Philippou.;Yeong Yeh Lee.;Daniele Salvi.;Alessandro Venturi.;Claudio Borghi.;Marco Zoli.;Paolo Gionchetti.;Pierluigi Viale.;Vincenzo Stanghellini.;Giovanni Barbara.; .
来源: Gut. 2022年
The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction after hospitalisation for SARS-CoV-2 infection.
1100. Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.
作者: Eloi R Verrier.;Gaëtan Ligat.;Laura Heydmann.;Katharina Doernbrack.;Julija Miller.;Anne Maglott-Roth.;Frank Jühling.;Houssein El Saghire.;Margaux J Heuschkel.;Naoto Fujiwara.;Sen-Yung Hsieh.;Yujin Hoshida.;David E Root.;Emanuele Felli.;Patrick Pessaux.;Atish Mukherji.;Laurent Mailly.;Catherine Schuster.;Laurent Brino.;Michael Nassal.;Thomas F Baumert.
来源: Gut. 2022年72卷9期1745-57页
Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by current treatments and whose elimination would be crucial for viral cure. To date, little is known about cccDNA formation. One major challenge to address this urgent question is the absence of robust models for the study of cccDNA biology.
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