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8341. HIV Infection Is Associated With Variability in Ventricular Repolarization: The Multicenter AIDS Cohort Study (MACS).
作者: Amir S Heravi.;Lacey H Etzkorn.;Jacek K Urbanek.;Ciprian M Crainiceanu.;Naresh M Punjabi.;Hiroshi Ashikaga.;Todd T Brown.;Matthew J Budoff.;Gypsyamber D'Souza.;Jared W Magnani.;Frank J Palella.;Ronald D Berger.;Katherine C Wu.;Wendy S Post.
来源: Circulation. 2020年141卷3期176-187页
People living with human immunodeficiency virus (HIV+) have greater risk for sudden arrhythmic death than HIV-uninfected (HIV-) individuals. HIV-associated abnormal cardiac repolarization may contribute to this risk. We investigated whether HIV serostatus is associated with ventricular repolarization lability by using the QT variability index (QTVI), defined as a log measure of QT-interval variance indexed to heart rate variance.
8343. Evaluating the Effects of Canagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease According to Baseline HbA1c, Including Those With HbA1c <7%: Results From the CREDENCE Trial.
作者: Christopher P Cannon.;Vlado Perkovic.;Rajiv Agarwal.;James Baldassarre.;George Bakris.;David M Charytan.;Dick de Zeeuw.;Robert Edwards.;Tom Greene.;Hiddo J L Heerspink.;Meg J Jardine.;Adeera Levin.;Jing-Wei Li.;Bruce Neal.;Carol Pollock.;David C Wheeler.;Hong Zhang.;Bernard Zinman.;Kenneth W Mahaffey.
来源: Circulation. 2020年141卷5期407-410页 8344. Effect of Empagliflozin on Erythropoietin Levels, Iron Stores, and Red Blood Cell Morphology in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease.
作者: C David Mazer.;Gregory M T Hare.;Philip W Connelly.;Richard E Gilbert.;Nadine Shehata.;Adrian Quan.;Hwee Teoh.;Lawrence A Leiter.;Bernard Zinman.;Peter Jüni.;Fei Zuo.;Nikhil Mistry.;Kevin E Thorpe.;Ronald M Goldenberg.;Andrew T Yan.;Kim A Connelly.;Subodh Verma.
来源: Circulation. 2020年141卷8期704-707页 8345. Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart.
作者: Kentaro Otani.;Takeshi Tokudome.;Chizuko A Kamiya.;Yuanjie Mao.;Hirohito Nishimura.;Takeshi Hasegawa.;Yuji Arai.;Mari Kaneko.;Go Shioi.;Junji Ishida.;Akiyoshi Fukamizu.;Tsukasa Osaki.;Chiaki Nagai-Okatani.;Naoto Minamino.;Takuya Ensho.;Jun Hino.;Shunsuke Murata.;Misa Takegami.;Kunihiro Nishimura.;Ichiro Kishimoto.;Mikiya Miyazato.;Mariko Harada-Shiba.;Jun Yoshimatsu.;Kazuwa Nakao.;Tomoaki Ikeda.;Kenji Kangawa.
来源: Circulation. 2020年141卷7期571-588页
The maternal circulatory system and hormone balance both change dynamically during pregnancy, delivery, and the postpartum period. Although atrial natriuretic peptides and brain natriuretic peptides produced in the heart control circulatory homeostasis through their common receptor, NPR1, the physiologic and pathophysiologic roles of endogenous atrial natriuretic peptide/brain natriuretic peptide in the perinatal period are not fully understood.
8346. High-Sensitivity Cardiac Troponin and the Universal Definition of Myocardial Infarction.
作者: Andrew R Chapman.;Philip D Adamson.;Anoop S V Shah.;Atul Anand.;Fiona E Strachan.;Amy V Ferry.;Kuan Ken Lee.;Colin Berry.;Iain Findlay.;Anne Cruikshank.;Alan Reid.;Alasdair Gray.;Paul O Collinson.;Fred Apple.;David A McAllister.;Donogh Maguire.;Keith A A Fox.;Catalina A Vallejos.;Catriona Keerie.;Christopher J Weir.;David E Newby.;Nicholas L Mills.; .
来源: Circulation. 2020年141卷3期161-171页
The introduction of more sensitive cardiac troponin assays has led to increased recognition of myocardial injury in acute illnesses other than acute coronary syndrome. The Universal Definition of Myocardial Infarction recommends high-sensitivity cardiac troponin testing and classification of patients with myocardial injury based on pathogenesis, but the clinical implications of implementing this guideline are not well understood.
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