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8261. Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome.
作者: Andrew J Kim.;Na Xu.;Kazuhiro Umeyama.;Alexia Hulin.;Sithara Raju Ponny.;Ronald J Vagnozzi.;Ellis A Green.;Paul Hanson.;Bruce M McManus.;Hiroshi Nagashima.;Katherine E Yutzey.
来源: Circulation. 2020年141卷2期132-146页
Myxomatous valve degeneration (MVD) involves the progressive thickening and degeneration of the heart valves, leading to valve prolapse, regurgitant blood flow, and impaired cardiac function. Leukocytes composed primarily of macrophages have recently been detected in myxomatous valves, but the timing of the presence and the contributions of these cells in MVD progression are not known.
8265. Confidence Weighting for Robust Automated Measurements of Popliteal Vessel Wall Magnetic Resonance Imaging.
作者: Daniel S Hippe.;Niranjan Balu.;Li Chen.;Gador Canton.;Wenjin Liu.;Hiroko Watase.;John C Waterton.;Thomas S Hatsukami.;Jenq-Neng Hwang.;Chun Yuan.
来源: Circ Genom Precis Med. 2020年13卷1期e002870页 8266. Prospective CYP2C19 Genotyping to Guide Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Pragmatic Randomized Clinical Trial.
作者: Sony Tuteja.;Henry Glick.;William Matthai.;Irving Nachamkin.;Ashwin Nathan.;Karen Monono.;Craig Carcuffe.;Karen Maslowski.;Gene Chang.;Taisei Kobayashi.;Saif Anwaruddin.;John Hirshfeld.;Robert L Wilensky.;Howard C Herrmann.;Daniel M Kolansky.;Daniel J Rader.;Jay Giri.
来源: Circ Genom Precis Med. 2020年13卷1期e002640页
CYP2C19 loss-of-function alleles impair clopidogrel effectiveness after percutaneous coronary intervention, but the clinical impact of implementing CYP2C19 genotyping in a real-world setting is unknown. The purpose of the study was to determine whether returning CYP2C19 genotype results along with genotype-guided pharmacotherapy recommendations using a rapid turnaround test would change antiplatelet prescribing following percutaneous coronary intervention.The primary outcome was the rate of prasugrel or ticagrelor prescribing in each arm. Secondary outcomes included agreement to the genotype-guided recommendations.
8267. Epigenome-Wide Association Study Identifies a Novel DNA Methylation in Patients With Severe Aortic Valve Stenosis.
作者: Takahito Nasu.;Mamoru Satoh.;Hideki Ohmomo.;Yuh Shiwa.;Shohei Komaki.;Kanako Ono.;Atsushi Shimizu.;Satoru Taguchi.;Yuji Takahashi.;Takuya Osaki.;Yoshihiro Morino.;Kenji Sobue.;Makoto Sasaki.
来源: Circ Genom Precis Med. 2020年13卷1期e002649页 8268. The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials.
Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular risk factors compared with other cooking oils using data from clinical trials.
8269. Genetically Determined High Levels of Iron Parameters Are Protective for Coronary Artery Disease.
作者: Niels Grote Beverborg.;M Abdullah Said.;Haye H van der Wal.;Niek Verweij.;Peter van der Meer.;Pim van der Harst.
来源: Circ Genom Precis Med. 2020年13卷1期e002544页 8270. Identification of Circulating Proteins Associated With Blood Pressure Using Mendelian Randomization.
作者: Sébastien Thériault.;Jennifer Sjaarda.;Michael Chong.;Sibylle Hess.;Hertzel Gerstein.;Guillaume Paré.
来源: Circ Genom Precis Med. 2020年13卷1期e002605页
Hypertension is a common modifiable risk factor for cardiovascular disease and mortality. Pathophysiological mechanisms leading to hypertension remain incompletely understood. Mendelian randomization (MR) allows the evaluation of the causal role of markers by minimizing the risk of biases such as reverse causation and confounding. We aimed to identify novel circulating proteins associated with blood pressure through a comprehensive screen of 227 blood biomarkers using MR.
8271. Deep Mutational Scan of an SCN5A Voltage Sensor.
作者: Andrew M Glazer.;Brett M Kroncke.;Kenneth A Matreyek.;Tao Yang.;Yuko Wada.;Tiffany Shields.;Joe-Elie Salem.;Douglas M Fowler.;Dan M Roden.
来源: Circ Genom Precis Med. 2020年13卷1期e002786页
Variants in ion channel genes have classically been studied in low throughput by patch clamping. Deep mutational scanning is a complementary approach that can simultaneously assess function of thousands of variants.
8273. Characterization of Structural Changes in Arrhythmogenic Right Ventricular Cardiomyopathy With Recurrent Ventricular Tachycardia After Ablation: Insights From Repeat Electroanatomic Voltage Mapping.
作者: David F Briceño.;Jackson J Liang.;Yasuhiro Shirai.;Timothy M Markman.;Anwar Chahal.;Cory Tschabrunn.;Erica Zado.;Mathew C Hyman.;Ramanan Kumareswaran.;Jeffery S Arkles.;Pasquale Santangeli.;Robert D Schaller.;Gregory E Supple.;David S Frankel.;Rajat Deo.;Michael P Riley.;Saman Nazarian.;David Lin.;Andrew E Epstein.;Fermin C Garcia.;Sanjay Dixit.;David J Callans.;Francis E Marchlinski.
来源: Circ Arrhythm Electrophysiol. 2020年13卷1期e007611页
Data characterizing structural changes of arrhythmogenic right ventricular (RV) cardiomyopathy are limited.
8275. Cardiac Rehabilitation Dose Around the World: Variation and Correlates.
作者: Gabriela Chaves.;Karam Turk-Adawi.;Marta Supervia.;Carolina Santiago de Araújo Pio.;Abdel-Hadi Abu-Jeish.;Taslima Mamataz.;Sergey Tarima.;Francisco Lopez Jimenez.;Sherry L Grace.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷1期e005453页
Cardiac rehabilitation (CR) is recommended in clinical practice guidelines, but dose prescribed varies highly by country. This study characterized the dose offered in supervised CR programs and alternative models worldwide and their potential correlates.
8276. Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice.
作者: Lu Gan.;Dina Xie.;Jing Liu.;Wayne Bond Lau.;Theodore A Christopher.;Bernard Lopez.;Ling Zhang.;Erhe Gao.;Walter Koch.;Xin-Liang Ma.;Yajing Wang.
来源: Circulation. 2020年141卷12期968-983页
Diabetes mellitus exacerbates myocardial ischemia/reperfusion (MI/R) injury by incompletely understood mechanisms. Adipocyte dysfunction contributes to remote organ injury. However, the molecular mechanisms linking dysfunctional adipocytes to increased MI/R injury remain unidentified. The current study attempted to clarify whether and how small extracellular vesicles (sEV) may mediate pathological communication between diabetic adipocytes and cardiomyocytes, exacerbating MI/R injury.
8277. Differential microRNA-21 and microRNA-221 Upregulation in the Biventricular Failing Heart Reveals Distinct Stress Responses of Right Versus Left Ventricular Fibroblasts.
作者: Jeffery C Powers.;Abdelkarim Sabri.;Dalia Al-Bataineh.;Dhruv Chotalia.;Xinji Guo.;Florence Tsipenyuk.;Remus Berretta.;Pavithra Kavitha.;Heramba Gopi.;Steven R Houser.;Mohsin Khan.;Emily J Tsai.;Fabio A Recchia.
来源: Circ Heart Fail. 2020年13卷1期e006426页
The failing right ventricle (RV) does not respond like the left ventricle (LV) to guideline-directed medical therapy of heart failure, perhaps due to interventricular differences in their molecular pathophysiology.
8279. 64Cu-ATSM Positron Emission Tomography/Magnetic Resonance Imaging of Hypoxia in Human Atherosclerosis.
作者: Xingyu Nie.;Andrew Elvington.;Richard Laforest.;Jie Zheng.;Thomas F Voller.;Mohamed A Zayed.;Dana R Abendschein.;Nilantha Bandara.;Jinbin Xu.;Ran Li.;Gwendalyn J Randolph.;Robert J Gropler.;Suzanne E Lapi.;Pamela K Woodard.
来源: Circ Cardiovasc Imaging. 2020年13卷1期e009791页 8280. Clinical Outcomes of Dynamic Computed Tomography Myocardial Perfusion Imaging Combined With Coronary Computed Tomography Angiography Versus Coronary Computed Tomography Angiography-Guided Strategy.
作者: Mengmeng Yu.;Chengxing Shen.;Xu Dai.;Zhigang Lu.;Yining Wang.;Bin Lu.;Jiayin Zhang.
来源: Circ Cardiovasc Imaging. 2020年13卷1期e009775页
Dynamic computed tomography (CT) myocardial perfusion imaging (MPI) provides quantitative myocardial blood flow for the precise assessment of myocardial ischemia. However, compared with coronary CT angiography (CCTA), whether this functional imaging modality can reduce invasive coronary angiography without revascularization remains unknown. We aimed to determine the clinical outcomes of a dynamic CT-MPI+CCTA-guided versus CCTA-guided strategy in patients with suspected coronary artery disease.
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