7908. Detection of Donor's HIV Strain in HIV-Positive Kidney-Transplant Recipient.
作者: Maria Blasi.;Hannah Stadtler.;Jerry Chang.;Marion Hemmersbach-Miller.;Christina Wyatt.;Paul Klotman.;Feng Gao.;Cameron Wolfe.;Mary Klotman.
来源: N Engl J Med. 2020年382卷2期195-197页 7914. Health Care Hotspotting - A Randomized, Controlled Trial.
作者: Amy Finkelstein.;Annetta Zhou.;Sarah Taubman.;Joseph Doyle.
来源: N Engl J Med. 2020年382卷2期152-162页
There is widespread interest in programs aiming to reduce spending and improve health care quality among "superutilizers," patients with very high use of health care services. The "hotspotting" program created by the Camden Coalition of Healthcare Providers (hereafter, the Coalition) has received national attention as a promising superutilizer intervention and has been expanded to cities around the country. In the months after hospital discharge, a team of nurses, social workers, and community health workers visits enrolled patients to coordinate outpatient care and link them with social services.
7915. Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes.
作者: Pierre Fenaux.;Uwe Platzbecker.;Ghulam J Mufti.;Guillermo Garcia-Manero.;Rena Buckstein.;Valeria Santini.;María Díez-Campelo.;Carlo Finelli.;Mario Cazzola.;Osman Ilhan.;Mikkael A Sekeres.;José F Falantes.;Beatriz Arrizabalaga.;Flavia Salvi.;Valentina Giai.;Paresh Vyas.;David Bowen.;Dominik Selleslag.;Amy E DeZern.;Joseph G Jurcic.;Ulrich Germing.;Katharina S Götze.;Bruno Quesnel.;Odile Beyne-Rauzy.;Thomas Cluzeau.;Maria-Teresa Voso.;Dominiek Mazure.;Edo Vellenga.;Peter L Greenberg.;Eva Hellström-Lindberg.;Amer M Zeidan.;Lionel Adès.;Amit Verma.;Michael R Savona.;Abderrahmane Laadem.;Aziz Benzohra.;Jennie Zhang.;Anita Rampersad.;Diana R Dunshee.;Peter G Linde.;Matthew L Sherman.;Rami S Komrokji.;Alan F List.
来源: N Engl J Med. 2020年382卷2期140-151页
Patients with anemia and lower-risk myelodysplastic syndromes in whom erythropoiesis-stimulating agent therapy is not effective generally become dependent on red-cell transfusions. Luspatercept, a recombinant fusion protein that binds transforming growth factor β superfamily ligands to reduce SMAD2 and SMAD3 signaling, showed promising results in a phase 2 study.
7919. Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.
作者: Sotirios Tsimikas.;Ewa Karwatowska-Prokopczuk.;Ioanna Gouni-Berthold.;Jean-Claude Tardif.;Seth J Baum.;Elizabeth Steinhagen-Thiessen.;Michael D Shapiro.;Erik S Stroes.;Patrick M Moriarty.;Børge G Nordestgaard.;Shuting Xia.;Jonathan Guerriero.;Nicholas J Viney.;Louis O'Dea.;Joseph L Witztum.; .
来源: N Engl J Med. 2020年382卷3期244-255页
Lipoprotein(a) levels are genetically determined and, when elevated, are a risk factor for cardiovascular disease and aortic stenosis. There are no approved pharmacologic therapies to lower lipoprotein(a) levels.
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