7870. Heat-Induced Brain Vitrification from the Vesuvius Eruption in c.e. 79.
作者: Pierpaolo Petrone.;Piero Pucci.;Massimo Niola.;Peter J Baxter.;Carolina Fontanarosa.;Guido Giordano.;Vincenzo Graziano.;Francesco Sirano.;Angela Amoresano.
来源: N Engl J Med. 2020年382卷4期383-384页 7877. Teprotumumab for the Treatment of Active Thyroid Eye Disease.
作者: Raymond S Douglas.;George J Kahaly.;Amy Patel.;Saba Sile.;Elizabeth H Z Thompson.;Renee Perdok.;James C Fleming.;Brian T Fowler.;Claudio Marcocci.;Michele Marinò.;Alessandro Antonelli.;Roger Dailey.;Gerald J Harris.;Anja Eckstein.;Jade Schiffman.;Rosa Tang.;Christine Nelson.;Mario Salvi.;Sara Wester.;Jeffrey W Sherman.;Thomas Vescio.;Robert J Holt.;Terry J Smith.
来源: N Engl J Med. 2020年382卷4期341-352页
Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular condition for which no Food and Drug Administration-approved medical therapy is available. Strong evidence has implicated the insulin-like growth factor I receptor (IGF-IR) in the pathogenesis of this disease.
7878. Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids.
作者: William D Schlaff.;Ronald T Ackerman.;Ayman Al-Hendy.;David F Archer.;Kurt T Barnhart.;Linda D Bradley.;Bruce R Carr.;Eve C Feinberg.;Sandra M Hurtado.;JinHee Kim.;Ran Liu.;R Garn Mabey.;Charlotte D Owens.;Alfred Poindexter.;Elizabeth E Puscheck.;Henry Rodriguez-Ginorio.;James A Simon.;Ahmed M Soliman.;Elizabeth A Stewart.;Nelson B Watts.;Ozgul Muneyyirci-Delale.
来源: N Engl J Med. 2020年382卷4期328-340页
Uterine fibroids are hormone-responsive neoplasms that are associated with heavy menstrual bleeding. Elagolix, an oral gonadotropin-releasing hormone antagonist resulting in rapid, reversible suppression of ovarian sex hormones, may reduce fibroid-associated bleeding.
7879. Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia.
作者: Helen S Marshall.;Mark McMillan.;Ann P Koehler.;Andrew Lawrence.;Thomas R Sullivan.;Jenny M MacLennan.;Martin C J Maiden.;Shamez N Ladhani.;Mary E Ramsay.;Caroline Trotter.;Ray Borrow.;Adam Finn.;Charlene M Kahler.;Jane Whelan.;Kumaran Vadivelu.;Peter Richmond.
来源: N Engl J Med. 2020年382卷4期318-327页
The meningococcal group B vaccine 4CMenB is a new, recombinant protein-based vaccine that is licensed to protect against invasive group B meningococcal disease. However, its role in preventing transmission and, therefore, inducing population (herd) protection is uncertain.
7880. Vaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England.
作者: Shamez N Ladhani.;Nick Andrews.;Sydel R Parikh.;Helen Campbell.;Joanne White.;Michael Edelstein.;Xilian Bai.;Jay Lucidarme.;Ray Borrow.;Mary E Ramsay.
来源: N Engl J Med. 2020年382卷4期309-317页
In September 2015, the United Kingdom introduced the multicomponent meningococcal group B vaccine (4CMenB, Bexsero) into its publicly funded national immunization program at a reduced two-dose priming schedule for infants, with a 12-month booster.
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