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7843. Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.
作者: Scott B Drutman.;Davood Mansouri.;Seyed Alireza Mahdaviani.;Anna-Lena Neehus.;David Hum.;Ruslana Bryk.;Nicholas Hernandez.;Serkan Belkaya.;Franck Rapaport.;Benedetta Bigio.;Robert Fisch.;Mahbuba Rahman.;Taushif Khan.;Fatima Al Ali.;Majid Marjani.;Nahal Mansouri.;Lazaro Lorenzo-Diaz.;Jean-François Emile.;Nico Marr.;Emmanuelle Jouanguy.;Jacinta Bustamante.;Laurent Abel.;Stéphanie Boisson-Dupuis.;Vivien Béziat.;Carl Nathan.;Jean-Laurent Casanova.
来源: N Engl J Med. 2020年382卷5期437-445页
Cytomegalovirus (CMV) can cause severe disease in children and adults with a variety of inherited or acquired T-cell immunodeficiencies, who are prone to multiple infections. It can also rarely cause disease in otherwise healthy persons. The pathogenesis of idiopathic CMV disease is unknown. Inbred mice that lack the gene encoding nitric oxide synthase 2 (Nos2) are susceptible to the related murine CMV infection.
7844. Family History of Gastric Cancer and Helicobacter pylori Treatment.
作者: Il Ju Choi.;Chan Gyoo Kim.;Jong Yeul Lee.;Young-Il Kim.;Myeong-Cherl Kook.;Boram Park.;Jungnam Joo.
来源: N Engl J Med. 2020年382卷5期427-436页
Helicobacter pylori infection and a family history of gastric cancer are the main risk factors for gastric cancer. Whether treatment to eradicate H. pylori can reduce the risk of gastric cancer in persons with a family history of gastric cancer in first-degree relatives is unknown.
7845. Soluble Urokinase Receptor and Acute Kidney Injury.
作者: Salim S Hayek.;David E Leaf.;Ayman Samman Tahhan.;Mohamad Raad.;Shreyak Sharma.;Sushrut S Waikar.;Sanja Sever.;Alex Camacho.;Xuexiang Wang.;Ranadheer R Dande.;Nasrien E Ibrahim.;Rebecca M Baron.;Mehmet M Altintas.;Changli Wei.;David Sheikh-Hamad.;Jenny S-C Pan.;Michael W Holliday.;James L Januzzi.;Steven D Weisbord.;Arshed A Quyyumi.;Jochen Reiser.
来源: N Engl J Med. 2020年382卷5期416-426页
Acute kidney injury is common, with a major effect on morbidity and health care utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein thought to be involved in the pathogenesis of kidney disease. We investigated whether a high level of suPAR predisposed patients to acute kidney injury in multiple clinical contexts, and we used experimental models to identify mechanisms by which suPAR acts and to assess it as a therapeutic target.
7846. Conservative versus Interventional Treatment for Spontaneous Pneumothorax.
作者: Simon G A Brown.;Emma L Ball.;Kyle Perrin.;Stephen E Asha.;Irene Braithwaite.;Diana Egerton-Warburton.;Peter G Jones.;Gerben Keijzers.;Frances B Kinnear.;Ben C H Kwan.;K V Lam.;Y C Gary Lee.;Mike Nowitz.;Catherine A Read.;Graham Simpson.;Julian A Smith.;Quentin A Summers.;Mark Weatherall.;Richard Beasley.; .
来源: N Engl J Med. 2020年382卷5期405-415页
Whether conservative management is an acceptable alternative to interventional management for uncomplicated, moderate-to-large primary spontaneous pneumothorax is unknown.
7849. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial.
作者: Harry J de Koning.;Carlijn M van der Aalst.;Pim A de Jong.;Ernst T Scholten.;Kristiaan Nackaerts.;Marjolein A Heuvelmans.;Jan-Willem J Lammers.;Carla Weenink.;Uraujh Yousaf-Khan.;Nanda Horeweg.;Susan van 't Westeinde.;Mathias Prokop.;Willem P Mali.;Firdaus A A Mohamed Hoesein.;Peter M A van Ooijen.;Joachim G J V Aerts.;Michael A den Bakker.;Erik Thunnissen.;Johny Verschakelen.;Rozemarijn Vliegenthart.;Joan E Walter.;Kevin Ten Haaf.;Harry J M Groen.;Matthijs Oudkerk.
来源: N Engl J Med. 2020年382卷6期503-513页
There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current smokers.
7850. Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement.
作者: Raj R Makkar.;Vinod H Thourani.;Michael J Mack.;Susheel K Kodali.;Samir Kapadia.;John G Webb.;Sung-Han Yoon.;Alfredo Trento.;Lars G Svensson.;Howard C Herrmann.;Wilson Y Szeto.;D Craig Miller.;Lowell Satler.;David J Cohen.;Todd M Dewey.;Vasilis Babaliaros.;Mathew R Williams.;Dean J Kereiakes.;Alan Zajarias.;Kevin L Greason.;Brian K Whisenant.;Robert W Hodson.;David L Brown.;William F Fearon.;Mark J Russo.;Philippe Pibarot.;Rebecca T Hahn.;Wael A Jaber.;Erin Rogers.;Ke Xu.;Jaime Wheeler.;Maria C Alu.;Craig R Smith.;Martin B Leon.; .
来源: N Engl J Med. 2020年382卷9期799-809页
There are scant data on long-term clinical outcomes and bioprosthetic-valve function after transcatheter aortic-valve replacement (TAVR) as compared with surgical aortic-valve replacement in patients with severe aortic stenosis and intermediate surgical risk.
7855. A Disclosure Form for Work Submitted to Medical Journals - A Proposal from the International Committee of Medical Journal Editors.
作者: Darren B Taichman.;Joyce Backus.;Christopher Baethge.;Howard Bauchner.;Annette Flanagin.;Fernando Florenzano.;Frank A Frizelle.;Fiona Godlee.;Laragh Gollogly.;Abraham Haileamlak.;Sung-Tae Hong.;Richard Horton.;Astrid James.;Christine Laine.;Pamela W Miller.;Anja Pinborg.;Eric J Rubin.;Peush Sahni.
来源: N Engl J Med. 2020年382卷7期667-668页 7856. A Novel Coronavirus from Patients with Pneumonia in China, 2019.
作者: Na Zhu.;Dingyu Zhang.;Wenling Wang.;Xingwang Li.;Bo Yang.;Jingdong Song.;Xiang Zhao.;Baoying Huang.;Weifeng Shi.;Roujian Lu.;Peihua Niu.;Faxian Zhan.;Xuejun Ma.;Dayan Wang.;Wenbo Xu.;Guizhen Wu.;George F Gao.;Wenjie Tan.; .
来源: N Engl J Med. 2020年382卷8期727-733页
In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.).
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