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7721. PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.
作者: Zhiyong Qi.;Liang Hu.;Jianjun Zhang.;Wenlong Yang.;Xin Liu.;Daile Jia.;Zhifeng Yao.;Lin Chang.;Guanxing Pan.;Haoxuan Zhong.;Xinping Luo.;Kang Yao.;Aijun Sun.;Juying Qian.;Zhongren Ding.;Junbo Ge.
来源: Circulation. 2021年143卷1期45-61页
PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein cholesterol by degrading low-density lipoprotein receptor. Pleiotropic effects of PCSK9 beyond lipid metabolism have been shown. However, the direct effects of PCSK9 on platelet activation and thrombosis, and the underlying mechanisms, as well, still remain unclear.
7722. Transcatheter Mitral Valve Replacement After Surgical Repair or Replacement: Comprehensive Midterm Evaluation of Valve-in-Valve and Valve-in-Ring Implantation From the VIVID Registry.
作者: Matheus Simonato.;Brian Whisenant.;Henrique Barbosa Ribeiro.;John G Webb.;Ran Kornowski.;Mayra Guerrero.;Harindra Wijeysundera.;Lars Søndergaard.;Ole De Backer.;Pedro Villablanca.;Charanjit Rihal.;Mackram Eleid.;Jörg Kempfert.;Axel Unbehaun.;Magdalena Erlebach.;Filip Casselman.;Matti Adam.;Matteo Montorfano.;Marco Ancona.;Francesco Saia.;Timm Ubben.;Felix Meincke.;Massimo Napodano.;Pablo Codner.;Joachim Schofer.;Marc Pelletier.;Anson Cheung.;Mony Shuvy.;José Honório Palma.;Diego Felipe Gaia.;Alison Duncan.;David Hildick-Smith.;Verena Veulemans.;Jan-Malte Sinning.;Yaron Arbel.;Luca Testa.;Arend de Weger.;Helene Eltchaninoff.;Thibault Hemery.;Uri Landes.;Didier Tchetche.;Nicolas Dumonteil.;Josep Rodés-Cabau.;Won-Keun Kim.;Konstantinos Spargias.;Panagiota Kourkoveli.;Ori Ben-Yehuda.;Rui Campante Teles.;Marco Barbanti.;Claudia Fiorina.;Arun Thukkani.;G Burkhard Mackensen.;Noah Jones.;Patrizia Presbitero.;Anna Sonia Petronio.;Abdelhakim Allali.;Didier Champagnac.;Sabine Bleiziffer.;Tanja Rudolph.;Alessandro Iadanza.;Stefano Salizzoni.;Marco Agrifoglio.;Luis Nombela-Franco.;Nikolaos Bonaros.;Malek Kass.;Giuseppe Bruschi.;Nicolas Amabile.;Adnan Chhatriwalla.;Antonio Messina.;Sameer A Hirji.;Martin Andreas.;Robert Welsh.;Wolfgang Schoels.;Farrel Hellig.;Stephan Windecker.;Stefan Stortecky.;Francesco Maisano.;Gregg W Stone.;Danny Dvir.
来源: Circulation. 2021年143卷2期104-116页
Mitral valve-in-valve (ViV) and valve-in-ring (ViR) are alternatives to surgical reoperation in patients with recurrent mitral valve failure after previous surgical valve repair or replacement. Our aim was to perform a large-scale analysis examining midterm outcomes after mitral ViV and ViR.
7725. Ten-Year Differences in Women's Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association.
作者: Mary Cushman.;Christina M Shay.;Virginia J Howard.;Monik C Jiménez.;Jennifer Lewey.;Jean C McSweeney.;L Kristin Newby.;Ram Poudel.;Harmony R Reynolds.;Kathryn M Rexrode.;Mario Sims.;Lori J Mosca.; .
来源: Circulation. 2021年143卷7期e239-e248页
High awareness that cardiovascular disease is the leading cause of death (LCOD) among women is critical to prevention. This study evaluated longitudinal trends in this awareness among women.
7726. Trends in Recurrent Coronary Heart Disease After Myocardial Infarction Among US Women and Men Between 2008 and 2017.
作者: Sanne A E Peters.;Lisandro D Colantonio.;Yuling Dai.;Hong Zhao.;Vera Bittner.;Michael E Farkouh.;Paul Dluzniewski.;Bharat Poudel.;Paul Muntner.;Mark Woodward.
来源: Circulation. 2021年143卷7期650-660页
Rates for recurrent coronary heart disease (CHD) events have declined in the United States. However, few studies have assessed whether this decline has been similar among women and men.
7727. Calcific Plaque Modification by Acoustic Shock Waves: Intravascular Lithotripsy in Coronary Interventions.
作者: Keyvan Karimi Galougahi.;Sanjay Patel.;Richard A Shlofmitz.;Akiko Maehara.;Dean J Kereiakes.;Jonathan M Hill.;Gregg W Stone.;Ziad A Ali.
来源: Circ Cardiovasc Interv. 2021年14卷1期e009354页
Constituting a significant proportion of lesions treated with transcatheter interventions in the coronary arteries, moderate-to-severe calcification portends lower procedural success rates, increased periprocedural major adverse events, and unfavorable long-term clinical outcomes compared with noncalcific plaques. Adapted from the lithotripsy technology for treatment of nephrolithiasis, intravascular lithotripsy is a new technique for treatment of severely calcific lesions that uses acoustic shock waves in a balloon-based system to induce fracture in the calcium deposits to facilitate luminal gain and stent expansion. Herein, we summarize the physics and characteristics of the currently available intravascular lithotripsy system (Shockwave Medical, Santa Clara, CA), the clinical data on intravascular lithotripsy use in the coronary arteries, and future directions for adoption of the technique in percutaneous coronary intervention.
7728. Striking Similarities of Multisystem Inflammatory Syndrome in Children and a Myocarditis-Like Syndrome in Adults: Overlapping Manifestations of COVID-19.
作者: Zachary M Most.;Nicholas Hendren.;Mark H Drazner.;Trish M Perl.
来源: Circulation. 2021年143卷1期4-6页 |