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7661. Meta-Analysis of 26 638 Individuals Identifies Two Genetic Loci Associated With Left Ventricular Ejection Fraction.
作者: Hélène Choquet.;Khanh K Thai.;Chen Jiang.;Dilrini K Ranatunga.;Thomas J Hoffmann.;Alan S Go.;Alistair C Lindsay.;Margaret G Ehm.;Dawn M Waterworth.;Neil Risch.;Catherine Schaefer.
来源: Circ Genom Precis Med. 2020年13卷4期e002804页
Left ventricular ejection fraction (EF) is an indicator of cardiac function, usually assessed in individuals with heart failure and other cardiac conditions. Although family studies indicate that EF has an important genetic component with heritability estimates up to 0.61, to date only 6 EF-associated loci have been reported.
7662. Association of Elevated High-Density Lipoprotein Cholesterol and Particle Concentration With Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis.
作者: Pratik B Sandesara.;Anurag Mehta.;Wesley T O'Neal.;Heval Mohamed Kelli.;Vasanth Sathiyakumar.;Seth S Martin.;Michael J Blaha.;Roger S Blumenthal.;Laurence S Sperling.
来源: Circ Cardiovasc Imaging. 2020年13卷7期e010473页 7665. Patient-Specific 3-Dimensional Printed Modeling of the Tricuspid Valve for MitraClip Procedure Planning.
作者: Marija Vukicevic.;Nadeen N Faza.;Eleonora Avenatti.;Ponraj Chinna Durai.;Kinan Carlos El-Tallawi.;Stefano Filippini.;Su Min Chang.;Stephen H Little.
来源: Circ Cardiovasc Imaging. 2020年13卷7期e010376页 7666. Kappa-light Chain Amyloid Overlapping Hypertrophic Cardiomyopathy With Myocardial Noncompaction.
作者: Andrea Frustaci.;Nicola Galea.;Romina Verardo.;Marco Francone.;Maria Alfarano.;Matteo Antonio Russo.;Cristina Chimenti.
来源: Circ Cardiovasc Imaging. 2020年13卷7期e010379页 7667. SOS1 Gain-of-Function Variants in Dilated Cardiomyopathy.
作者: Jason R Cowan.;Lorien Salyer.;Nathan T Wright.;Daniel D Kinnamon.;Pedro Amaya.;Elizabeth Jordan.;Michael J Bamshad.;Deborah A Nickerson.;Ray E Hershberger.
来源: Circ Genom Precis Med. 2020年13卷4期e002892页
Dilated cardiomyopathy (DCM) is a genetically heterogeneous cardiac disease characterized by progressive ventricular enlargement and reduced systolic function. Here, we report genetic and functional analyses implicating the rat sarcoma signaling protein, SOS1 (Son of sevenless homolog 1), in DCM pathogenesis.
7668. Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase).
作者: Dorina Ibi.;Raymond Noordam.;Jan Bert van Klinken.;Ruifang Li-Gao.;Renée de Mutsert.;Stella Trompet.;Tim Christen.;Lisanne L Blauw.;Diana van Heemst.;Dennis O Mook-Kanamori.;Frits R Rosendaal.;J Wouter Jukema.;Martijn E T Dollé.;Patrick C N Rensen.;Ko Willems van Dijk.
来源: Circ Genom Precis Med. 2020年13卷4期e002693页
The increase in serum triglyceride (TG) concentrations in response to a meal is considered a risk factor for cardiovascular disease. We aimed to elucidate the genetics of the postprandial TG response through genome-wide association studies (GWAS).
7669. Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits.
作者: Antoine R Baldassari.;Colleen M Sitlani.;Heather M Highland.;Dan E Arking.;Steve Buyske.;Dawood Darbar.;Rahul Gondalia.;Misa Graff.;Xiuqing Guo.;Susan R Heckbert.;Lucia A Hindorff.;Chani J Hodonsky.;Yii-Der Ida Chen.;Robert C Kaplan.;Ulrike Peters.;Wendy Post.;Alex P Reiner.;Jerome I Rotter.;Ralph V Shohet.;Amanda A Seyerle.;Nona Sotoodehnia.;Ran Tao.;Kent D Taylor.;Genevieve L Wojcik.;Jie Yao.;Eimear E Kenny.;Henry J Lin.;Elsayed Z Soliman.;Eric A Whitsel.;Kari E North.;Charles Kooperberg.;Christy L Avery.
来源: Circ Genom Precis Med. 2020年13卷4期e002680页
We examined how expanding electrocardiographic trait genome-wide association studies to include ancestrally diverse populations, prioritize more precise phenotypic measures, and evaluate evidence for shared genetic effects enabled the detection and characterization of loci.
7670. Munich Comparative Study: Prospective Long-Term Outcome of the Transcatheter Melody Valve Versus Surgical Pulmonary Bioprosthesis With Up to 12 Years of Follow-Up.
作者: Stanimir Georgiev.;Peter Ewert.;Andreas Eicken.;Alfred Hager.;Jürgen Hörer.;Julie Cleuziou.;Christian Meierhofer.;Daniel Tanase.
来源: Circ Cardiovasc Interv. 2020年13卷7期e008963页
Percutaneous pulmonary valve implantation (PPVI) has become an important treatment of right ventricular outflow tract dysfunction. Studies directly comparing the long-term outcome of PPVI with the Melody valve to surgical pulmonary valve replacement (SPVR) are lacking.
7671. Effect of the COVID-19 Pandemic on ST-Segment-Elevation Myocardial Infarction Presentations and In-Hospital Outcomes.
作者: Simon J Wilson.;Michelle J Connolly.;Ziyad Elghamry.;Claudia Cosgrove.;Sami Firoozi.;Pitt Lim.;Rajan Sharma.;James C Spratt.
来源: Circ Cardiovasc Interv. 2020年13卷7期e009438页 7672. Determinants and Impact of Heart Failure Readmission Following Transcatheter Aortic Valve Replacement.
作者: Vincent Auffret.;Abdelkader Bakhti.;Guillaume Leurent.;Marc Bedossa.;Jacques Tomasi.;Reda Belhaj Soulami.;Jean-Philippe Verhoye.;Erwan Donal.;Elena Galli.;Aurélie Loirat.;Sam Sharobeem.;Gwenaelle Sost.;Marielle Le Guellec.;Dominique Boulmier.;Hervé Le Breton.
来源: Circ Cardiovasc Interv. 2020年13卷7期e008959页
Heart failure (HF) readmission is common post-transcatheter aortic valve replacement (TAVR). Nonetheless, limited data are available regarding its predictors and clinical impact. This study evaluated the incidence, predictors, and impact of HF readmission within 1-year post-TAVR, and assessed the effects of the prescription of HF therapies at discharge on the risk of HF readmission and death.
7673. Cardiovascular Health Score and Lifetime Risk of Cardiovascular Disease: The Cardiovascular Lifetime Risk Pooling Project.
作者: Joshua D Bundy.;Hongyan Ning.;Victor W Zhong.;Amanda E Paluch.;Donald M Lloyd-Jones.;John T Wilkins.;Norrina B Allen.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷7期e006450页
Long-term risks of cardiovascular disease (CVD) according to levels of cardiovascular health (CVH) have not been characterized in a diverse, representative population.
7674. Association Between Neighborhood Social Risk and Hospital Readmission Reduction Penalties Under the New Stratified Approach: Is Dual Eligibility Adjustment Enough?
作者: Alexander T Sandhu.;Rebecca Tisdale.;Karen E Joynt Maddox.;Paul A Heidenreich.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷7期e006353页 7675. gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration.
作者: Yandong Li.;Jie Feng.;Shen Song.;Haotong Li.;Huijun Yang.;Bin Zhou.;Yan Li.;Zhang Yue.;Hong Lian.;Lihui Liu.;Shengshou Hu.;Yu Nie.
来源: Circulation. 2020年142卷10期967-982页
A key cause of the high mortality of cardiovascular diseases is the cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement functional myocytes for cardiac repair, there is a pressing need to understand the cellular and molecular mechanisms of heart regeneration.
7676. Increased Burden of Ion Channel Gene Variants Is Related to Distinct Phenotypes in Pediatric Patients With Left Ventricular Noncompaction.
作者: Keiichi Hirono.;Yukiko Hata.;Nariaki Miyao.;Mako Okabe.;Shinya Takarada.;Hideyuki Nakaoka.;Keijiro Ibuki.;Sayaka Ozawa.;Hideki Origasa.;Naoki Nishida.;Fukiko Ichida.; .
来源: Circ Genom Precis Med. 2020年13卷4期e002940页
Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy. Although it is associated with high morbidity and mortality, the related ion channel gene variants in children have not been fully investigated. This study aimed to elucidate the ion channel genetic landscape of LVNC and identify genotype-phenotype correlations in a large Japanese cohort.
7677. Genome-Wide Association of Kidney Traits in Hispanics/Latinos Using Dense Imputed Whole-Genome Sequencing Data: The Hispanic Community Health Study/Study of Latinos.
作者: Huijun Qian.;Madeline H Kowalski.;Holly J Kramer.;Ran Tao.;James P Lash.;Adrienne M Stilp.;Jianwen Cai.;Yun Li.;Nora Franceschini.
来源: Circ Genom Precis Med. 2020年13卷4期e002891页
Genetic factors that influence kidney traits have been understudied for low-frequency and ancestry-specific variants.
7678. Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated With Increased Mortality in Patients With Chronic Heart Failure.
作者: Sebastian Cremer.;Klara Kirschbaum.;Alexander Berkowitsch.;David John.;Katharina Kiefer.;Lena Dorsheimer.;Julian Wagner.;Tina Rasper.;Khalil Abou-El-Ardat.;Birgit Assmus.;Hubert Serve.;Michael Rieger.;Stefanie Dimmeler.;Andreas M Zeiher.
来源: Circ Genom Precis Med. 2020年13卷4期e003003页 7679. Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy.
作者: Dan Shao.;Stephen C Kolwicz.;Pei Wang.;Nathan D Roe.;Outi Villet.;Kiyoto Nishi.;Yun-Wei A Hsu.;Galina V Flint.;Arianne Caudal.;Wang Wang.;Michael Regnier.;Rong Tian.
来源: Circulation. 2020年142卷10期983-997页
Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes mellitus-induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acid transport into mitochondria via deletion of acetyl coenzyme A carboxylase 2 (ACC2) does not cause cardiomyopathy in nonobese mice, suggesting that high FAO is distinct from cardiac lipotoxicity. We hypothesize that cardiac pathology-associated obesity is attributable to the imbalance of fatty acid supply and oxidation. Thus, we here seek to determine whether further increasing FAO by inducing ACC2 deletion prevents obesity-induced cardiomyopathy, and if so, to elucidate the underlying mechanisms.
7680. Carotid Atherosclerosis Evolution When Targeting a Low-Density Lipoprotein Cholesterol Concentration <70 mg/dL After an Ischemic Stroke of Atherosclerotic Origin.
作者: Pierre Amarenco.;Cristina Hobeanu.;Julien Labreuche.;Hugo Charles.;Maurice Giroud.;Elena Meseguer.;Philippa C Lavallée.;Philippe Gabriel Steg.;Éric Vicaut.;Eric Bruckert.;Pierre-Jean Touboul.
来源: Circulation. 2020年142卷8期748-757页
The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL in terms of reducing the risk of major cardiovascular events in 2860 patients with ischemic stroke with atherosclerotic stenosis of cerebral vasculature. The impact on carotid atherosclerosis evolution is not known.
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