7675. A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.
作者: Kenneth S Koblan.;Justine Kent.;Seth C Hopkins.;John H Krystal.;Hailong Cheng.;Robert Goldman.;Antony Loebel.
来源: N Engl J Med. 2020年382卷16期1497-1506页
An oral compound, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A) receptors, may represent a new class of psychotropic agent for the treatment of psychosis in schizophrenia.
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