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743. Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990-2021: findings from the Global Burden of Disease Study 2021.
Stillbirth is a devastating and often avoidable adverse pregnancy outcome. Monitoring stillbirth levels and trends-in a comprehensive manner that leaves no one uncounted-is imperative for continuing progress in pregnancy loss reduction. This analysis, completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, methodically accounted for different stillbirth definitions with the aim of comprehensively estimating all stillbirths at 20 weeks or longer for 204 countries and territories from 1990 to 2021.
753. Equitable access to pandemic products demands stronger public governance.
作者: Adam Strobeyko.;Caesar A Atuire.;Ruth Faden.;Calvin W L Ho.;Vitor Ido.;Mohga Kamal-Yanni.;Matthew Kavanagh.;Katherine Littler.;Lauren Paremoer.;Alexandra L Phelan.;Katerini T Storeng.;Ross Upshur.;Suerie Moon.
来源: Lancet. 2024年404卷10467期2030-2032页 754. Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial.
作者: David J Werring.;Hakim-Moulay Dehbi.;Norin Ahmed.;Liz Arram.;Jonathan G Best.;Maryam Balogun.;Kate Bennett.;Ekaterina Bordea.;Emilia Caverly.;Marisa Chau.;Hannah Cohen.;Mairead Cullen.;Caroline J Doré.;Stefan T Engelter.;Robert Fenner.;Gary A Ford.;Aneet Gill.;Rachael Hunter.;Martin James.;Archana Jayanthi.;Gregory Y H Lip.;Sue Massingham.;Macey L Murray.;Iwona Mazurczak.;Philip S Nash.;Amalia Ndoutoumou.;Bo Norrving.;Hannah Sims.;Nikola Sprigg.;Tishok Vanniyasingam.;Nick Freemantle.; .
来源: Lancet. 2024年
The optimal timing of anticoagulation for patients with acute ischaemic stoke with atrial fibrillation is uncertain. We investigated the efficacy and safety of early compared with delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischaemic stroke associated with atrial fibrillation.
758. Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials.
作者: Robin W M Vernooij.;Carinna Hockham.;Giovanni Strippoli.;Suetonia Green.;Jörgen Hegbrant.;Andrew Davenport.;Claudia Barth.;Bernard Canaud.;Mark Woodward.;Peter J Blankestijn.;Michiel L Bots.; .; .
来源: Lancet. 2024年
High-dose haemodiafiltration has been shown, in a randomised clinical trial, to result in a 23% lower risk of mortality for patients with kidney failure when compared with conventional high-flux haemodialysis. Nevertheless, whether treatment effects differ across subgroups, whether a dose-response relationship with convection volume exists, and the effects on cause-specific mortality remain unclear. The aim of this individual patient data meta-analysis was to compare the effects of haemodiafiltration and standard haemodialysis on all-cause and cause-specific mortality.
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