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7521. Plaster cast versus functional brace for non-surgical treatment of Achilles tendon rupture (UKSTAR): a multicentre randomised controlled trial and economic evaluation.
作者: Matthew L Costa.;Juul Achten.;Ioana R Marian.;Susan J Dutton.;Sarah E Lamb.;Benjamin Ollivere.;Mandy Maredza.;Stavros Petrou.;Rebecca S Kearney.; .
来源: Lancet. 2020年395卷10222期441-448页
Patients with Achilles tendon rupture who have non-operative treatment have traditionally been treated with immobilisation of the tendon in plaster casts for several weeks. Functional bracing is an alternative non-operative treatment that allows earlier mobilisation, but evidence on its effectiveness and safety is scarce. The aim of the UKSTAR trial was to compare functional and quality-of-life outcomes and resource use in patients treated non-operatively with plaster cast versus functional brace.
7522. Bimekizumab in patients with active psoriatic arthritis: results from a 48-week, randomised, double-blind, placebo-controlled, dose-ranging phase 2b trial.
作者: Christopher T Ritchlin.;Arthur Kavanaugh.;Joseph F Merola.;Georg Schett.;Jose U Scher.;Richard B Warren.;Alice B Gottlieb.;Deepak Assudani.;Kathy Bedford-Rice.;Jason Coarse.;Barbara Ink.;Iain B McInnes.
来源: Lancet. 2020年395卷10222期427-440页
Dual neutralisation of interleukin 17A (IL17A) and interleukin 17F (IL17F) is a potential novel therapeutic approach in psoriatic arthritis. We assessed bimekizumab, a monoclonal antibody that selectively neutralises IL17A and IL17F, in patients with active psoriatic arthritis.
7523. Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial.
Closure of an abdominal stoma, a common elective operation, is associated with frequent complications; one of the commonest and impactful is incisional hernia formation. We aimed to investigate whether biological mesh (collagen tissue matrix) can safely reduce the incidence of incisional hernias at the stoma closure site.
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