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7442. Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study.
作者: Marius Gilbert.;Giulia Pullano.;Francesco Pinotti.;Eugenio Valdano.;Chiara Poletto.;Pierre-Yves Boëlle.;Eric D'Ortenzio.;Yazdan Yazdanpanah.;Serge Paul Eholie.;Mathias Altmann.;Bernardo Gutierrez.;Moritz U G Kraemer.;Vittoria Colizza.
来源: Lancet. 2020年395卷10227期871-877页
The novel coronavirus disease 2019 (COVID-19) epidemic has spread from China to 25 countries. Local cycles of transmission have already occurred in 12 countries after case importation. In Africa, Egypt has so far confirmed one case. The management and control of COVID-19 importations heavily rely on a country's health capacity. Here we evaluate the preparedness and vulnerability of African countries against their risk of importation of COVID-19.
7444. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.
作者: Michael D Hill.;Mayank Goyal.;Bijoy K Menon.;Raul G Nogueira.;Ryan A McTaggart.;Andrew M Demchuk.;Alexandre Y Poppe.;Brian H Buck.;Thalia S Field.;Dar Dowlatshahi.;Brian A van Adel.;Richard H Swartz.;Ruchir A Shah.;Eric Sauvageau.;Charlotte Zerna.;Johanna M Ospel.;Manish Joshi.;Mohammed A Almekhlafi.;Karla J Ryckborst.;Mark W Lowerison.;Kathy Heard.;David Garman.;Diogo Haussen.;Shawna M Cutting.;Shelagh B Coutts.;Daniel Roy.;Jeremy L Rempel.;Axel Cr Rohr.;Daniela Iancu.;Demetrios J Sahlas.;Amy Y X Yu.;Thomas G Devlin.;Ricardo A Hanel.;Volker Puetz.;Frank L Silver.;Bruce C V Campbell.;René Chapot.;Jeanne Teitelbaum.;Jennifer L Mandzia.;Timothy J Kleinig.;David Turkel-Parrella.;Donald Heck.;Michael E Kelly.;Aditya Bharatha.;Oh Young Bang.;Ashutosh Jadhav.;Rishi Gupta.;Donald F Frei.;Jason W Tarpley.;Cameron G McDougall.;Staffan Holmin.;Joung-Ho Rha.;Ajit S Puri.;Marie-Christine Camden.;Götz Thomalla.;Hana Choe.;Stephen J Phillips.;Joseph L Schindler.;John Thornton.;Simon Nagel.;Ji Hoe Heo.;Sung-Il Sohn.;Marios-Nikos Psychogios.;Ronald F Budzik.;Sidney Starkman.;Coleman O Martin.;Paul A Burns.;Seán Murphy.;George A Lopez.;Joey English.;Michael Tymianski.; .
来源: Lancet. 2020年395卷10227期878-887页
Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.
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