当前位置: 首页 >> 检索结果
7441. Impairments in Blood Pressure Regulation and Cardiac Baroreceptor Sensitivity Among Patients With Heart Failure Supported With Continuous-Flow Left Ventricular Assist Devices.
作者: Christine Sailer.;Hannah Edelmann.;Cullen Buchanan.;Pedro Giro.;Matthew Babcock.;Christine Swanson.;Melanie Spotts.;Margaret Schulte.;Ashley Pratt-Cordova.;Greg Coe.;Mark Beindorff.;Robert L Page.;Amrut V Ambardekar.;Jay D Pal.;Wendy Kohrt.;Eugene Wolfel.;Justin S Lawley.;Takashi Tarumi.;William K Cornwell.
来源: Circ Heart Fail. 2021年14卷1期e007448页
Continuous-flow (CF) left ventricular assist devices (LVADs) improve outcomes for patients with advanced heart failure (HF). However, the lack of a physiological pulse predisposes to side-effects including uncontrolled blood pressure (BP), and there are little data regarding the impact of CF-LVADs on BP regulation.
7442. Defining Shock and Preshock for Mortality Risk Stratification in Cardiac Intensive Care Unit Patients.
作者: Jacob C Jentzer.;Barry Burstein.;Sean Van Diepen.;Joseph Murphy.;David R Holmes.;Malcolm R Bell.;Gregory W Barsness.;Timothy D Henry.;Venu Menon.;Charanjit S Rihal.;Srihari S Naidu.;David A Baran.
来源: Circ Heart Fail. 2021年14卷1期e007678页
Previous studies have defined preshock as isolated hypotension or isolated hypoperfusion, whereas shock has been variably defined as hypoperfusion with or without hypotension. We aimed to evaluate the mortality risk associated with hypotension and hypoperfusion at the time of admission in a cardiac intensive care unit population.
7444. Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease.
作者: Sander Trenson.;Hadewich Hermans.;Sander Craps.;Peter Pokreisz.;Pauline de Zeeuw.;Jore Van Wauwe.;Hilde Gillijns.;Denise Veltman.;Fangfei Wei.;Ellen Caluwé.;Rik Gijsbers.;Pieter Baatsen.;Jan A Staessen.;Bart Ghesquiere.;Peter Carmeliet.;Filip Rega.;Bart Meuris.;Bart Meyns.;Wouter Oosterlinck.;Jürgen Duchenne.;Kaatje Goetschalckx.;Jens-Uwe Voigt.;Marie-Christine Herregods.;Paul Herijgers.;Aernout Luttun.;Stefan Janssens.
来源: Circ Heart Fail. 2021年14卷1期e006979页
Chronic pressure overload predisposes to heart failure, but the pathogenic role of microvascular endothelial cells (MiVEC) remains unknown. We characterized transcriptional, metabolic, and functional adaptation of cardiac MiVEC to pressure overload in mice and patients with aortic stenosis (AS).
7445. Letter by Mirwais et al Regarding Article, "Lower Rates of Heart Failure and All-Cause Hospitalizations During Pulmonary Artery Pressure-Guided Therapy for Ambulatory Heart Failure".7446. Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease.
While many of the cardiac limitations to exercise performance are now well-characterized, extracardiac limitations to exercise performance have been less well recognized but are nevertheless important. We propose that abnormalities of cardiac preload reserve represents an under-recognized but common cause of exercise limitations. We further propose that mechanistic links exist between conditions as seemingly disparate as heart failure with preserved ejection fraction, nonalcoholic fatty liver disease, and pelvic venous compression/obstruction syndromes (eg, May-Thurner). We conclude that extracardiac abnormalities of preload reserve serve as a major pathophysiologic mechanism underlying these and other disease states.
7447. Letter by Baldetti et al Regarding Article, "Lower Rates of Heart and All-Cause Hospitalizations During Pulmonary Artery Pressure-Guided Therapy for Ambulatory Heart Failure".
作者: Luca Baldetti.;Matteo Pagnesi.;Alberto Maria Cappelletti.
来源: Circ Heart Fail. 2021年14卷1期e007918页 7452. Left Atrial Volumetric/Mechanical Coupling Index: A Novel Predictor of Outcome in Heart Failure With Reduced Ejection Fraction.
作者: Giovanni Benfari.;Benjamin Essayagh.;Stefano Nistri.;Joseph Maalouf.;Andrea Rossi.;Prabin Thapa.;Hector I Michelena.;Maurice Enriquez-Sarano.
来源: Circ Cardiovasc Imaging. 2021年14卷1期e011608页
Left atrial assessment is complex, particularly in heart failure with reduced ejection fraction due to interactions with functional mitral regurgitation (FMR). Pilot data suggest that left atrial volumetric/mechanical coupling index (LACI) may be useful, but large outcome data are lacking.
7453. Myocardial Inflammation and Dysfunction in COVID-19-Associated Myocardial Injury.
作者: Ludwig T Weckbach.;Adrian Curta.;Stephanie Bieber.;Angelina Kraechan.;Johannes Brado.;Johannes C Hellmuth.;Maximilian Muenchhoff.;Clemens Scherer.;Ines Schroeder.;Michael Irlbeck.;Stefan Maurus.;Jens Ricke.;Karin Klingel.;Stefan Kääb.;Mathias Orban.;Steffen Massberg.;Jörg Hausleiter.;Ulrich Grabmaier.
来源: Circ Cardiovasc Imaging. 2021年14卷1期e012220页
Myocardial injury, defined by elevated troponin levels, is associated with adverse outcome in patients with coronavirus disease 2019 (COVID-19). The frequency of cardiac injury remains highly uncertain and confounded in current publications; myocarditis is one of several mechanisms that have been proposed.
7456. Isolevuglandin-Modified Cardiac Proteins Drive CD4+ T-Cell Activation in the Heart and Promote Cardiac Dysfunction.
作者: Njabulo Ngwenyama.;Annet Kirabo.;Mark Aronovitz.;Francisco Velázquez.;Francisco Carrillo-Salinas.;Ane M Salvador.;Tania Nevers.;Venkataraman Amarnath.;Albert Tai.;Robert M Blanton.;David G Harrison.;Pilar Alcaide.
来源: Circulation. 2021年143卷12期1242-1255页
Despite the well-established association between T-cell-mediated inflammation and nonischemic heart failure, the specific mechanisms triggering T-cell activation during the progression of heart failure and the antigens involved are poorly understood. We hypothesized that myocardial oxidative stress induces the formation of isolevuglandin (IsoLG)-modified proteins that function as cardiac neoantigens to elicit CD4+ T-cell receptor (TCR) activation and promote heart failure.
7458. Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.
作者: Ziad Hijazi.;John H Alexander.;Zhuokai Li.;Daniel M Wojdyla.;Roxana Mehran.;Christopher B Granger.;Alexander Parkhomenko.;M Cecilia Bahit.;Stephan Windecker.;Ronald Aronson.;Otavio Berwanger.;Sigrun Halvorsen.;Suzanne de Waha-Thiele.;Peter Sinnaeve.;Harald Darius.;Robert F Storey.;Renato D Lopes.
来源: Circulation. 2021年143卷12期1215-1223页
In the AUGUSTUS trial (An Open-Label, 2×2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban Versus Vitamin K Antagonist and Aspirin Versus Aspirin Placebo in Patients With Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention), apixaban resulted in less bleeding and fewer hospitalizations than vitamin K antagonists, and aspirin caused more bleeding than placebo in patients with atrial fibrillation and acute coronary syndrome or percutaneous coronary intervention treated with a P2Y12 inhibitor. We evaluated the risk-benefit balance of antithrombotic therapy according to kidney function.
7459. Spatially Weighted Coronary Artery Calcium Score and Coronary Heart Disease Events in the Multi-Ethnic Study of Atherosclerosis.
作者: Steven Shea.;Ana Navas-Acien.;Daichi Shimbo.;Elizabeth R Brown.;Matthew Budoff.;Michael P Bancks.;R Graham Barr.;Richard Kronmal.
来源: Circ Cardiovasc Imaging. 2021年14卷1期e011981页
A limitation of the Agatston coronary artery calcium (CAC) score is that it does not use all of the calcium density information in the computed tomography scan such that many individuals have a score of zero. We examined the predictive validity for incident coronary heart disease (CHD) events of the spatially weighted coronary calcium score (SWCS), an alternative scoring method for CAC that assigns scores to individuals with Agatston CAC=0.
|