7297. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.
作者: Ayumu Arakawa.;Hitoshi Ichikawa.;Takashi Kubo.;Noriko Motoi.;Tadashi Kumamoto.;Miho Nakajima.;Kan Yonemori.;Emi Noguchi.;Kuniko Sunami.;Kouya Shiraishi.;Hiroki Kakishima.;Hiroshi Yoshida.;Tomoro Hishiki.;Naonori Kawakubo.;Takafumi Kuroda.;Takako Kiyokawa.;Kyosuke Yamada.;Nozomu Yanaihara.;Kazuaki Takahashi.;Aikou Okamoto.;Shinsuke Hirabayashi.;Daisuke Hasegawa.;Atsushi Manabe.;Kentaro Ono.;Masaki Matsuoka.;Yasuhito Arai.;Yosuke Togashi.;Tatsuhiro Shibata.;Hiroyoshi Nishikawa.;Kazunori Aoki.;Noboru Yamamoto.;Takashi Kohno.;Chitose Ogawa.
来源: N Engl J Med. 2021年384卷1期42-50页
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child. (Funded by the Japan Agency for Medical Research and Development and others; TOP-GEAR UMIN Clinical Trials Registry number, UMIN000011141.).
7298. Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease.
作者: Sherif S Farag.;Mohammad Abu Zaid.;Jennifer E Schwartz.;Teresa C Thakrar.;Ann J Blakley.;Rafat Abonour.;Michael J Robertson.;Hal E Broxmeyer.;Shuhong Zhang.
来源: N Engl J Med. 2021年384卷1期11-19页
Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has a costimulatory function in activating T cells. In a mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether inhibition of DPP-4 with sitagliptin may prevent acute GVHD after allogeneic stem-cell transplantation is not known.
7300. Misrepresenting Race - The Role of Medical Schools in Propagating Physician Bias.
作者: Christina Amutah.;Kaliya Greenidge.;Adjoa Mante.;Michelle Munyikwa.;Sanjna L Surya.;Eve Higginbotham.;David S Jones.;Risa Lavizzo-Mourey.;Dorothy Roberts.;Jennifer Tsai.;Jaya Aysola.
来源: N Engl J Med. 2021年384卷9期872-878页 |