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7261. [18F]FDG positron emission tomography and ultrasound in the diagnosis of giant cell arteritis: congruent or complementary imaging methods?
作者: Stephan Imfeld.;Markus Aschwanden.;Christof Rottenburger.;Elke Schegk.;Christoph T Berger.;Daniel Staub.;Thomas Daikeler.
来源: Rheumatology (Oxford). 2020年59卷4期772-778页
[18F]Fluorodeoxyglucose (FDG)-PET/CT and US are both well established for diagnosing GCA. The present study investigates their accuracy and whether they provide overlapping or complementary information in a cohort of patients presenting with suspicion of GCA.
7262. Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry.
作者: Martina Bonifazi.;Nicola Sverzellati.;Eva Negri.;Giovanni Pomponio.;Valeria Seletti.;Matteo Bonini.;Paolo Fraticelli.;Luca Paolini.;Massimo Mattioli.;Matteo Franchi.;Irene Tramacere.;Venerino Poletti.;Carlo La Vecchia.;Stefano Gasparini.;Armando Gabrielli.
来源: Rheumatology (Oxford). 2020年59卷3期641-649页
The prevalence and clinical implications of small airways involvement in SSc are still to be fully elucidated. The goal of the present work is to assess the prevalence of small airways dysfunction by impulse oscillometry and to determine whether it correlates with selected disease-related features and respiratory-related quality of life.
7263. Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients.
作者: Yanying Liu.;Miao Xue.;Zhenfan Wang.;Qiaozhu Zeng.;Limin Ren.;Yanyan Zhang.;Shanshan Zhang.;Yi Wang.;Danhua Shen.;Changsheng Xia.;Guangyan Yu.;Zhan-Guo Li.
来源: Rheumatology (Oxford). 2020年59卷3期634-640页
IgG4-related disease (IgG4-RD) has recently been recognized as a fibro-inflammatory condition featuring tumefactive lesions in multiple organs, and the salivary gland is one of the most commonly involved sites. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-RD patients with salivary gland lesions (IgG4-RD SG+) and salivary-gland-free IgG4-RD (IgG4-RD SG-) in a large cohort.
7264. Defining remission in rheumatoid arthritis: does it matter to the patient? A comparison of multi-dimensional remission criteria and patient reported outcomes.
作者: Hanna L Gul.;Gisella Eugenio.;Thibault Rabin.;Agata Burska.;Rekha Parmar.;Jianhua Wu.;Frederique Ponchel.;Paul Emery.
来源: Rheumatology (Oxford). 2020年59卷3期613-621页
In a cross-sectional study, we evaluated the prevalence of 'multi-dimensional remission' (MDR) and its component parameters, assessed using objective measures in a cohort of RA patients in treatment-induced DAS28-remission, and their relationship with patient-reported outcome measures. We sought to confirm the feasibility and face validity of the MDR construct, providing a platform for future longitudinal studies in which its clinical utility might be further established.
7265. Right ventricular dimension index by cardiac magnetic resonance for prognostication in connective tissue diseases and pulmonary hypertension.
作者: Nobuya Abe.;Masaru Kato.;Michihito Kono.;Yuichiro Fujieda.;Hiroshi Ohira.;Ichizo Tsujino.;Noriko Oyama-Manabe.;Kenji Oku.;Toshiyuki Bohgaki.;Shinsuke Yasuda.;Tatsuya Atsumi.
来源: Rheumatology (Oxford). 2020年59卷3期622-633页
Pulmonary hypertension (PH) in patients with CTD is a heterogeneous condition affected by left heart disease, chronic lung disease and thromboembolism as well as pulmonary vascular disease. Recent studies using cardiac magnetic resonance (CMR) have shown that right ventricular dysfunction is predictive for mortality in patients with PH, but limited to pulmonary arterial hypertension. This study aimed to analyse prognostic factors in PH-CTD.
7266. Pregnancy outcomes in DMARD-exposed patients with juvenile idiopathic arthritis-results from a JIA biologic registry.
作者: Paula Drechsel.;Katrin Stüdemann.;Martina Niewerth.;Gerd Horneff.;Rebecca Fischer-Betz.;Eva Seipelt.;Susanna Spähtling-Mestekemper.;Peer Aries.;Angela Zink.;Jens Klotsche.;Kirsten Minden.
来源: Rheumatology (Oxford). 2020年59卷3期603-612页
To investigate the courses and outcomes of pregnancies involving JIA patients who were exposed to DMARDs.
7268. Top down or bottom up? An observational investigation of improvement in fibromyalgia symptoms following hip and knee replacement.
作者: Andrew Schrepf.;Stephanie Moser.;Steven E Harte.;Neil Basu.;Chelsea Kaplan.;Ellen Kolarik.;Alexander Tsodikov.;Chad M Brummett.;Daniel J Clauw.
来源: Rheumatology (Oxford). 2020年59卷3期594-602页
Many patients with osteoarthritis have comorbid symptoms of FM, but it is unknown how these symptoms respond to surgical procedures that address nociceptive input in the periphery, such as total joint replacement. Here we explore differences in clinical characteristics between patients whose FM symptoms do and do not improve following total hip or knee replacement.
7269. Sudanese and Swedish patients with systemic lupus erythematosus: immunological and clinical comparisons.
作者: Sahwa Elbagir.;Amir I Elshafie.;Elnour M Elagib.;NasrEldeen A Mohammed.;Mawahib I E Aledrissy.;Azita Sohrabian.;Musa A M Nur.;Elisabet Svenungsson.;Iva Gunnarsson.;Johan Rönnelid.
来源: Rheumatology (Oxford). 2020年59卷5期968-978页
SLE is known to have an aggressive phenotype in black populations, but data from African cohorts are largely lacking. We therefore compared immunological and clinical profiles between Sudanese and Swedish patients using similar tools.
7270. Improvement of MEFV gene variants classification to aid treatment decision making in familial Mediterranean fever.
作者: Matteo Accetturo.;Angela Maria D'Uggento.;Piero Portincasa.;Alessandro Stella.
来源: Rheumatology (Oxford). 2020年59卷4期754-761页
FMF is an inherited autoinflammatory syndrome caused by mutations in the MEFV gene. MEFV variants are still largely classified as acvariant of uncertain significance, or with unresolved classification, posing significant challenges in FMF diagnosis. Rare Exome Variant Ensemble Learner (REVEL) is a recently developed variant metapredictor tool. To reduce the number of MEFV variants with ambiguous classification, we extracted REVEL scores for all missense variants present in the INFEVERS database, and analysed its correlation with expert-based classification and localization in the MEFV-encoded pyrin functional domains.
7272. Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain.
作者: Sampurna Chakrabarti.;Deepak R Jadon.;David C Bulmer.;Ewan St John Smith.
来源: Rheumatology (Oxford). 2020年59卷3期662-667页
Knee OA is a leading global cause of morbidity. This study investigates the effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory neurons that innervate the knee (knee neurons) as a novel translational model of disease-mediated nociception in human OA.
7273. Enthesopathy and involvement of synovio-entheseal complex in systemic sclerosis: an ultrasound pilot study.
作者: Riccardo Terenzi.;Rositsa Karalilova.;Gemma Lepri.;Cosimo Bruni.;Silvia Bellando-Randone.;Mirko Manetti.;Eloisa Romano.;Daniela Melchiorre.;Jelena Blagojevic.;Yukai Wang.;Kamal Solanki.;Alberto Moggi-Pignone.;Zguro Batalov.;Serena Guiducci.;Anastas Batalov.;Marco Matucci-Cerinic.
来源: Rheumatology (Oxford). 2020年59卷3期580-585页
SSc is a chronic autoimmune disease characterized by inflammation of the skin and multiple internal organs. Articular involvement is one of the main features of SSc, and typical hallmarks of SpA have been found in SSc patients. The aim of the present study was to estimate the prevalence of entheseal and synovio-entheseal complex (SEC) alterations in a cohort of SSc patients.
7274. Predictive factors for sustained remission with stratification by myositis-specific autoantibodies in adult polymyositis/dermatomyositis.
作者: Eri Watanabe.;Takahisa Gono.;Masataka Kuwana.;Chihiro Terai.
来源: Rheumatology (Oxford). 2020年59卷3期586-593页
The aim of this study was to clarify predictive factors for sustained remission in adult patients with PM/DM, particularly focusing on stratification by myositis-specific autoantibodies (MSAs).
7275. Next generation sequencing panel in undifferentiated autoinflammatory diseases identifies patients with colchicine-responder recurrent fevers.
作者: Riccardo Papa.;Marta Rusmini.;Stefano Volpi.;Roberta Caorsi.;Paolo Picco.;Alice Grossi.;Francesco Caroli.;Francesca Bovis.;Valeria Musso.;Laura Obici.;Cinzia Castana.;Angelo Ravelli.;Marielle E Van Gijn.;Isabella Ceccherini.;Marco Gattorno.
来源: Rheumatology (Oxford). 2020年59卷2期458页 7276. Nurse-led care is preferred over GP-led care of gout and improves gout outcomes: results of Nottingham Gout Treatment Trial follow-up study.
作者: Amy Fuller.;Wendy Jenkins.;Michael Doherty.;Abhishek Abhishek.
来源: Rheumatology (Oxford). 2020年59卷3期575-579页
To explore patient satisfaction, gout knowledge, medication adherence and flares among participants receiving nurse-led or general practitioner (GP)-led care of gout in the Nottingham Gout Treatment Trial phase-II (NGTT-II).
7277. Experience with tofacitinib in Canada: patient characteristics and treatment patterns in rheumatoid arthritis over 3 years.
作者: Janet Pope.;Louis Bessette.;Niall Jones.;Lara Fallon.;John Woolcott.;David Gruben.;Michael Crooks.;David Gold.;Boulos Haraoui.
来源: Rheumatology (Oxford). 2020年59卷3期568-574页
To describe characteristics, treatment patterns and persistence in patients with RA treated with tofacitinib, an oral Janus kinase inhibitor, in Canadian clinical practice between 1 June 2014 and 31 May 2017.
7278. British kindred with dominant FMF associated with high incidence of AA amyloidosis caused by novel MEFV variant, and a review of the literature.
作者: Dorota M Rowczenio.;Taryn Youngstein.;Hadija Trojer.;Ebun Omoyinmi.;Anna Baginska.;Paul Brogan.;Charalampia Papadopoulou.;Tamer Rezk.;Philip N Hawkins.;Helen J Lachmann.
来源: Rheumatology (Oxford). 2020年59卷3期554-558页
Hereditary systemic autoinflammatory diseases are rare genetic disorders, which if untreated, can be complicated by AA amyloidosis leading to renal failure and premature death. Our objective was to find a genetic cause in a British family with a dominantly inherited autoinflammatory disease complicated by AA amyloidosis.
7279. Clinical characteristics of cancer-associated myositis complicated by interstitial lung disease: a large-scale multicentre cohort study.
作者: Yuko Kaneko.;Takahiro Nunokawa.;Yoshinori Taniguchi.;Yukie Yamaguchi.;Takahisa Gono.;Kenichi Masui.;Atsushi Kawakami.;Yasushi Kawaguchi.;Shinji Sato.;Masataka Kuwana.; .
来源: Rheumatology (Oxford). 2020年59卷1期112-119页
To clarify the incidence, risk factors, and impact of malignancy in patients with PM/DM-associated interstitial lung disease (ILD).
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