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7182. Immunization to rituximab is more frequent in systemic autoimmune diseases than in rheumatoid arthritis: ofatumumab as alternative therapy.
作者: Alice Combier.;Gaétane Nocturne.;Julien Henry.;Rakiba Belkhir.;Stephan Pavy.;Clotilde Le Tiec.;Elise Descamps.;Raphaele Seror.;Xavier Mariette.
来源: Rheumatology (Oxford). 2020年59卷6期1347-1354页
The frequency and consequences of anti-drug antibodies to rituximab (RTX-ADA) are not well known in RA and even less in other systemic auto-immune diseases (sAID). We aimed to evaluate the frequency, consequences and predictive factors of RTX-ADA in RA and sAID.
7184. The risk of uveitis in patients with JIA receiving etanercept: the challenges of analysing real-world data.
作者: Rebecca Davies.;Diederik De Cock.;Lianne Kearsley-Fleet.;Taunton Southwood.;Eileen Baildam.;Michael W Beresford.;Helen E Foster.;Wendy Thomson.;Athimalaipet V Ramanan.;Kimme L Hyrich.; .
来源: Rheumatology (Oxford). 2020年59卷6期1391-1397页
To describe and compare the occurrence of newly diagnosed uveitis in children with JIA receiving MTX, etanercept, adalimumab and infliximab.
7185. The effects of long non-coding ribonucleic acids on various cellular components in rheumatoid arthritis.
作者: Yilong Fang.;Jiajie Tu.;Dafei Han.;Yawei Guo.;Wenming Hong.;Wei Wei.
来源: Rheumatology (Oxford). 2020年59卷1期46-56页
RA is a chronic, autoimmune-mediated inflammatory pathology. Long non-coding RNAs (lncRNAs) are a novel group of non-coding RNAs with a length of >200 nucleotides. There are reports emerging that suggest that lncRNAs participate in establishing and sustaining autoimmune diseases, including RA. In this review article, we highlight the functions of lncRNAs in different cell types in RA. Our review indicates that lncRNAs affect various cellular components and are novel candidates that could constitute promising targets for the diagnosis and treatment of RA.
7186. 'It can't be zero!' Difficulties in completing patient global assessment in rheumatoid arthritis: a mixed methods study.
作者: Ricardo J O Ferreira.;Maarten de Wit.;Marta Henriques.;Ana F Pinto.;Cátia Duarte.;Elsa Mateus.;Gabriel Mendes.;José A P da Silva.;Mwidimi Ndosi.
来源: Rheumatology (Oxford). 2020年59卷5期1137-1147页
Patient global assessment (PGA) is purported to add the patient's perspective in the composite measures of RA. However, PGA is not standardized and it is not known whether patients' interpretation of the measure is consistent with its intended purpose. This study aimed to explore difficulties experienced by patients with RA in completing PGA, and to assess the impact of a structured explanation in improving its validity and reliability.
7187. MRI of the sacroiliac joints in athletes: recognition of non-specific bone marrow oedema by semi-axial added to standard semi-coronal scans.
作者: Ulrich Weber.;Anne Grethe Jurik.;Anna Zejden.;Ejnar Larsen.;Steen Hylgaard Jørgensen.;Kaspar Rufibach.;Christian Schioldan.;Søren Schmidt-Olsen.
来源: Rheumatology (Oxford). 2020年59卷6期1381-1390页
Assessment of combined semi-axial and semi-coronal SI joint MRI in two cohorts of young athletes to explore frequency and topography of non-specific bone marrow oedema (BMO), its association with four constitutional SI joint features, and potential restriction of false-positive assignments of Assessment of SpondyloArthritis International Society-defined sacroiliitis on standard semi-coronal scans alone.
7188. Outcomes of acute cardiovascular events in rheumatoid arthritis and systemic lupus erythematosus: a population-based study.
作者: Chao-Han Lai.;Cheng-Yang Hsieh.;April Barnado.;Li-Ching Huang.;Sheau-Chiann Chen.;Liang-Miin Tsai.;Yu Shyr.;Chung-Yi Li.
来源: Rheumatology (Oxford). 2020年59卷6期1355-1363页
Patients with RA and SLE have an excess cardiovascular risk. We aimed to evaluate outcomes of acute cardiovascular events in these patients.
7189. Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.
作者: Nisha Nair.;Darren Plant.;Suzanne M Verstappen.;John D Isaacs.;Ann W Morgan.;Kimme L Hyrich.;Anne Barton.;Anthony G Wilson.; .
来源: Rheumatology (Oxford). 2020年59卷6期1364-1371页
Identifying blood-based biomarkers that predict treatment response in RA is a clinical priority. We investigated differential DNA methylation as a candidate biomarker of response for the first-line drug used in RA, MTX.
7190. A patient with stimulator of interferon genes-associated vasculopathy with onset in infancy without skin vasculopathy.
作者: Carmela Gerarda Luana Raffaele.;Virginia Messia.;Gianmarco Moneta.;Ivan Caiello.;Silvia Federici.;Manuela Pardeo.;Claudia Bracaglia.;Fabrizio De Benedetti.;Antonella Insalaco.
来源: Rheumatology (Oxford). 2020年59卷4期905-907页 7191. Comorbidities in familial Mediterranean fever: analysis of 2000 genetically confirmed patients.
作者: Banu Balcı-Peynircioğlu.;Ümmüşen Kaya-Akça.;Zehra Serap Arıcı.;Edibe Avcı.;Z Yeliz Akkaya-Ulum.;Ömer Karadağ.;Umut Kalyoncu.;Yelda Bilginer.;Engin Yılmaz.;Seza Özen.
来源: Rheumatology (Oxford). 2020年59卷6期1372-1380页
FMF is the most common periodic fever syndrome, characterized by recurrent episodes of fever and serosal inflammation accompanied with high acute phase reactants. The analysis of possible comorbidities is important to understand the impact of these conditions on clinical care and whether they share a common aetiological pathway. In this study, we aimed to evaluate the comorbidities associated with FMF patients in a large genetically diagnosed cohort.
7194. Pregnancy and undifferentiated connective tissue disease: outcome and risk of flare in 100 pregnancies.
作者: Dina Zucchi.;Chiara Tani.;Francesca Monacci.;Elena Elefante.;Linda Carli.;Alice Parma.;Chiara Stagnaro.;Francesco Ferro.;Sabrina Gori.;Francesca Anna Letizia Strigini.;Marta Mosca.
来源: Rheumatology (Oxford). 2020年59卷6期1335-1339页
UCTD is a systemic autoimmune condition that fails to fulfil the criteria for a definite CTD. Given that there are a lack of studies on links between pregnancy and UCTD, the purpose of this study was to evaluate the risk of disease flares or development of CTD in addition to the risk of adverse pregnancy outcomes in patients with UCTD.
7195. Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomitant psoriasis?
作者: Joy Feld.;Justine Yang Ye.;Vinod Chandran.;Robert D Inman.;Nigil Haroon.;Richard Cook.;Dafna D Gladman.
来源: Rheumatology (Oxford). 2020年59卷6期1340-1346页
The aim of this study was to compare patients with ankylosing spondylitis with psoriasis (ASP) and without psoriasis (AS), to axial PsA (axPsA) patients.
7200. Lower urinary tract symptoms in systemic sclerosis: a detailed investigation.
作者: Greta Pacini.;Sabrina Paolino.;Amelia C Trombetta.;Federica Goegan.;Carmen Pizzorni.;Elisa Alessandri.;Massimo Patanè.;Emanuele Gotelli.;Giorgia Ferrari.;Francesco Cattelan.;Massimo Ghio.;Andrea Casabella.;Vanessa Smith.;Maurizio Cutolo.
来源: Rheumatology (Oxford). 2020年59卷6期1315-1324页
Urinary tract involvement is a seldom-reported manifestation of SSc that could compromise patients' quality of life. This study compares lower urinary tract symptoms (LUTS) in SSc patients and in healthy subjects and their association with clinical and diagnostic parameters.
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