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701. Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial.
作者: Yvonne M Mowery.;Karla V Ballman.;Angela M Hong.;Scott M Schuetze.;Andrew J Wagner.;Varun Monga.;Rachel S Heise.;Steven Attia.;Edwin Choy.;Melissa A Burgess.;Susie Bae.;David I Pryor.;Brian A Van Tine.;Gabriel Tinoco.;Bartosz Chmielowski.;Carolyn Freeman.;Alessandro Gronchi.;Christian F Meyer.;Mark A Dickson.;Lee Hartner.;Lara E Davis.;Benjamin C Powers.;Everett J Moding.;Kent J Weinhold.;Matt van de Rijn.;Brian E Brigman.;Richard F Riedel.;David G Kirsch.
来源: Lancet. 2024年404卷10467期2053-2064页
Approximately half of patients with localised, high-risk soft tissue sarcoma of the extremity develop metastases. We aimed to assess whether the addition of pembrolizumab to preoperative radiotherapy and surgery would improve disease-free survival.
704. Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial.
作者: Jianwen Guo.;Xiaoying Chen.;Manli Wu.;Dou Wang.;Yang Zhao.;Qiang Li.;Guanghai Tang.;Fengyuan Che.;Zhangyong Xia.;Zai Liang.;Liu Shi.;Qiuhua Jiang.;Yajie Chen.;Xiaoqiu Liu.;Xinwen Ren.;Menglu Ouyang.;Borui Wang.;Shoujiang You.;Laurent Billot.;Xia Wang.;Zhenchuan Liu.;Hongyan Jing.;Wei Meng.;Song Tian.;Enzhi Liu.;Yong Xiang.;Xiaoping Tang.;Tingting Xie.;Wanzhen Cui.;Yanwen Zheng.;Jiamin Cao.;Jingbei Zhang.;Zehuai Wen.;Tao Huang.;Lixin Wang.;Chao You.;Suyue Pan.;Yefeng Cai.;Yun Lu.;Graeme J Hankey.;Rustam Al-Shahi Salman.;Craig S Anderson.;Lili Song.; .
来源: Lancet. 2024年404卷10468期2187-2196页
There are few proven treatments for acute spontaneous intracerebral haemorrhage, and they all target reducing expansion of the haematoma. The traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao) in an oral solution is comprised of several Chinese herbs that are widely used to treat patients with intracerebral haemorrhage in China on the understanding that they enhance resorption of the haematoma and reduce neuroinflammation. We aimed to provide a reliable assessment of the safety and efficacy of FYTF-919 in patients with moderate to severe acute intracerebral haemorrhage.
707. Mobilising the health community to protect health care from attack.
作者: Martin Chalfie.;Leonard Rubenstein.;Lujain Alqodmani.;Georges C Benjamin.;Pamela F Cipriano.;Carlos Del Rio.;Victor J Dzau.;Timothy Johnson.;Robert S Lawrence.;Michele Heisler.
来源: Lancet. 2024年404卷10470期2399-2402页 709. Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial.
作者: Janet L Kwiatkowski.;Mark C Walters.;Suradej Hongeng.;Evangelia Yannaki.;Andreas E Kulozik.;Joachim B Kunz.;Martin G Sauer.;Adrian J Thrasher.;Isabelle Thuret.;Ashutosh Lal.;Ge Tao.;Shamshad Ali.;Himal L Thakar.;Heidi Elliot.;Ankit Lodaya.;Ji Lee.;Richard A Colvin.;Franco Locatelli.;Alexis A Thompson.
来源: Lancet. 2024年404卷10468期2175-2186页
Transfusion-dependent β-thalassaemia (TDT) is a severe disease, resulting in lifelong blood transfusions, iron overload, and associated complications. Betibeglogene autotemcel (beti-cel) gene therapy uses autologous haematopoietic stem and progenitor cells (HSPCs) transduced with BB305 lentiviral vector to enable transfusion independence.
711. Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan.
作者: Takeshi Soma.;Yoshinori Oie.;Hiroshi Takayanagi.;Shoko Matsubara.;Tomomi Yamada.;Masaki Nomura.;Yu Yoshinaga.;Kazuichi Maruyama.;Atsushi Watanabe.;Kayo Takashima.;Zaixing Mao.;Andrew J Quantock.;Ryuhei Hayashi.;Kohji Nishida.
来源: Lancet. 2024年404卷10466期1929-1939页
The loss of corneal epithelial stem cells from the limbus at the edge of the cornea has severe consequences for vision, with the pathological manifestations of a limbal stem-cell deficiency (LSCD) difficult to treat. Here, to the best of our knowledge, we report the world's first use of corneal epithelial cell sheets derived from human induced pluripotent stem cells (iPSCs) to treat LSCD.
713. Disparities in wellbeing in the USA by race and ethnicity, age, sex, and location, 2008-21: an analysis using the Human Development Index.
作者: Laura Dwyer-Lindgren.;Parkes Kendrick.;Mathew M Baumann.;Zhuochen Li.;Chris Schmidt.;Dillon O Sylte.;Farah Daoud.;Wichada La Motte-Kerr.;Robert W Aldridge.;Catherine Bisignano.;Simon I Hay.;Ali H Mokdad.;Christopher J L Murray.
来源: Lancet. 2024年404卷10469期2261-2277页
The Human Development Index (HDI)-a composite metric encompassing a population's life expectancy, education, and income-is used widely for assessing and comparing human development and wellbeing at the country level, but does not account for within-country inequality. In this study of the USA, we aimed to adapt the HDI framework to measure the HDI at an individual level to examine disparities in the distribution of wellbeing by race and ethnicity, sex, age, and geographical location.
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