7150. Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection.
作者: Kimberly Page.;Michael T Melia.;Rebecca T Veenhuis.;Matthew Winter.;Kimberly E Rousseau.;Guido Massaccesi.;William O Osburn.;Michael Forman.;Elaine Thomas.;Karla Thornton.;Katherine Wagner.;Ventzislav Vassilev.;Lan Lin.;Paula J Lum.;Linda C Giudice.;Ellen Stein.;Alice Asher.;Soju Chang.;Richard Gorman.;Marc G Ghany.;T Jake Liang.;Michael R Wierzbicki.;Elisa Scarselli.;Alfredo Nicosia.;Antonella Folgori.;Stefania Capone.;Andrea L Cox.
来源: N Engl J Med. 2021年384卷6期541-549页
A safe and effective vaccine to prevent chronic hepatitis C virus (HCV) infection is a critical component of efforts to eliminate the disease.
7151. Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant.
作者: Margaret R Chow.;Andrianna I Ayiotis.;Desi P Schoo.;Yoav Gimmon.;Kelly E Lane.;Brian J Morris.;Mehdi A Rahman.;Nicolas S Valentin.;Peter J Boutros.;Stephen P Bowditch.;Bryan K Ward.;Daniel Q Sun.;Carolina Treviño Guajardo.;Michael C Schubert.;John P Carey.;Charles C Della Santina.
来源: N Engl J Med. 2021年384卷6期521-532页
Bilateral vestibular hypofunction is associated with chronic disequilibrium, postural instability, and unsteady gait owing to failure of vestibular reflexes that stabilize the eyes, head, and body. A vestibular implant may be effective in alleviating symptoms.
7152. Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis.
作者: Andrew Blauvelt.;Steven Kempers.;Edward Lain.;Todd Schlesinger.;Stephen Tyring.;Seth Forman.;Glynis Ablon.;George Martin.;Hui Wang.;David L Cutler.;Jane Fang.;Min-Fun R Kwan.; .
来源: N Engl J Med. 2021年384卷6期512-520页
The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, a precursor of squamous-cell carcinoma.
7158. Once-Weekly Semaglutide in Adults with Overweight or Obesity.
作者: John P H Wilding.;Rachel L Batterham.;Salvatore Calanna.;Melanie Davies.;Luc F Van Gaal.;Ildiko Lingvay.;Barbara M McGowan.;Julio Rosenstock.;Marie T D Tran.;Thomas A Wadden.;Sean Wharton.;Koutaro Yokote.;Niels Zeuthen.;Robert F Kushner.; .
来源: N Engl J Med. 2021年384卷11期989-1002页
Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed.
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